Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Abstract
This
study
assessed
the
association
between
Chronic
Kidney
Disease
(CKD)
and
presbycusis
to
investigate
whether
inflammatory
neutrophil
percentage-to-albumin
ratio
(NPAR)
indicators
influence
this
relationship.This
used
data
from
National
Health
Nutrition
Examination
Surve
employed
such
as
restricted
cubic
spline
analysis,
multiple
logistic
regression
analyses
mediation
explore
these
relationships.High-frequency
Hearing
Impairment(HI)
was
correlated
with
moderate
CKD
(OR
=
3.25,
95%
CI
1.25–8.46,
P
0.02).
HI
grades
were
[for
slight
HI,
5.13,
1.48–17.86,
0.01);
for
severe
4.68,
1.29–17.04,
0.02)].
Mediation
analysis
revealed
that
NPAR
had
a
17.85%
mediating
effect
on
presbycusis.Moderate
associated
high-frequency
in
elderly
significant
relationship.
Frontiers in Public Health,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 2, 2024
The
inflammatory
response
holds
paramount
significance
in
the
context
of
intracerebral
hemorrhage
(ICH)
and
exhibits
a
robust
correlation
with
mortality
rates.
Biological
markers
such
as
neutrophil-to-lymphocyte
ratio
(NLR),
platelet-to-lymphocyte
(PLR),
lymphocyte-to-monocyte
(LMR),
systemic
immune
inflammation
index
(SII),
(SIRI)
play
crucial
roles
influencing
following
ICH.
This
study
aims
to
compare
predictive
efficacy
NLR,
PLR,
LMR,
SII,
SIRI
concerning
risk
intensive
care
unit
(ICU)
among
critically
ill
patients
Such
comparison
seeks
elucidate
their
early
warning
capabilities
management
treatment
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 23, 2024
Background
The
combined
effect
of
depression
and
nutritional-inflammatory
status
on
mortality
in
the
chronic
kidney
disease
(CKD)
population
is
unclear.
Methods
We
prospectively
analyzed
3,934
(weighted
population:
22,611,423)
CKD
participants
from
National
Health
Nutrition
Examination
Survey
(2007–2018).
Depression
were
assessed
with
Patient
Questionnaire
9
(PHQ-9)
Advanced
Lung
Cancer
Inflammation
Index
(ALI),
respectively.
Weighted
multivariate
COX
regression
models,
restricted
cubic
splines
(RCS)
stratified
analyses
used
to
investigate
association
PHQ-9
scores
ALI
all-cause
mortality.
Results
During
a
median
follow-up
5.8
years
(interquartile
range
3.4–8.6
years),
total
985
patients
died
(25.0%).
Each
point
increase
patient’s
score
increased
risk
by
4%
(HR,
1.04;
95%
CI,
1.02–1.06;
p
<
0.001),
full
adjusted
model.
However,
an
levels
was
associated
decreased
risk.
HRs
(95%
CI)
0.76
(0.65–0.90),
0.70
(0.57–0.86),
0.51
(0.41–0.64)
Q2,
Q3,
Q4
compared
Q1
ALI,
In
addition,
joint
analysis
showed
that
without
higher
reduced
Namely,
highest
group
(Q4)
had
lowest
0.32;
0.21–0.48).
Furthermore,
this
consistent
across
all
subgroups,
no
significant
interaction
found
(
>
0.05
for
interaction).
Conclusion
nationally
representative
sample
US
CKD,
coexisting
poorer
nutrition-inflammation
significantly
Medicine,
Journal Year:
2024,
Volume and Issue:
103(45), P. e40224 - e40224
Published: Nov. 8, 2024
The
hemoglobin-to-red
blood
cell
distribution
width
ratio
(HRR)
is
recognized
as
a
novel
prognostic
biomarker;
however,
studies
exploring
its
relationship
with
chronic
kidney
disease
(CKD)
are
scarce.
This
study
used
data
from
the
National
Health
and
Nutrition
Examination
Survey
database
2005
to
2018.
analysis
included
individuals
aged
≥
20
years
who
had
complete
HRR
CKD
data.
Weighted
univariate
multivariate
logistic
regression
analyses
were
assess
association
between
prevalence.
Additionally,
restricted
cubic
spline
subgroup
conducted
for
further
validation.
Ultimately,
19,426
participants
in
this
study.
After
adjusting
confounders,
revealed
negative
(OR
=
0.35,
95%
CI
0.22–0.56).
In
addition,
linear
CKD,
higher
levels
of
associated
lower
prevalence
CKD.
that
was
stronger
male
population.
negatively
adult
population
US.
potential
indicator
assessing
provides
rationale
personalized
management.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 23, 2024
Objectives
Observational
studies
have
identified
an
association
between
dried
fruit
intake
and
kidney
function.
However,
these
limitations
such
as
vulnerability
to
confounders
reverse
causality
bias.
Therefore,
this
study
aimed
explore
the
potential
causal
relationship
Methods
A
two-sample
Mendelian
randomization
(MR)
was
conducted
using
a
large-scale
genome-wide
dataset
investigate
function
markers
(blood
urea
nitrogen
(BUN),
creatinine
(CR),
uric
acid
(UA),
cystatin
C
(CyC),
hematuria,
microalbuminuria).
The
main
analytical
method
inverse
variance
weighting.
In
addition,
we
applied
MR
Egger
weighted
median
assess
robustness
of
results.
Finally,
Multivariate
(MVMR)
used
estimate
direct
effect
on
markers.
Results
univariate
analysis
showed
that
increased
associated
with
lower
markers,
including
BUN
(
β
:
−0.171,
95%
confidence
interval
(CI):
−0.239
−0.102,
p
=
1.063
×
10
−6
),
CR
−0.205,
CI:
−0.311
−0.099,
1.455
−4
UA
−0.317,
−0.384
−0.249,
4.439
−20
CysC
−0.323,
1.074
−11
);
however,
it
unrelated
hematuria
microalbuminuria.
Causality
persisted
after
performing
MVMR
analysis;
addition
alcohol
consumption
smoking
exposure
factors,
for
−0.296,
−0.523
−0.068,
1.094
−2
)
−0.238,
−0.465
−0.011,
4.024×
weakened,
while
−0.038,
−0.215
0.138,
6.698
−1
−0.431
0.046,
1.347
disappeared.
Conclusion
Increased
(BUN,
CR,
UA,
CysC)
in
absence
consumption;
disappeared
presence
consumption.
These
results
provide
promising
avenue
delaying
course
chronic
disease.
BMJ Open,
Journal Year:
2024,
Volume and Issue:
14(11), P. e084920 - e084920
Published: Nov. 1, 2024
Objectives
This
study
aims
to
investigate
the
association
of
physical
activity
(PA)
and
sedentary
behaviour
(SB)
with
chronic
kidney
disease
(CKD),
illustrate
whether
inflammatory
biomarkers
play
a
mediating
role.
Design
A
cross-sectional
study.
Setting
analysed
data
from
National
Health
Nutrition
Examination
Survey
2007–2018.
Participants
total
27
808
participants
aged
20–80
years
old
were
enrolled
in
final
analysis.
Outcome
measures
PA
SB
self-reported
by
using
Global
Physical
Activity
Questionnaire.
Inflammatory
including
neutrophil/lymphocyte
ratio
(NLR),
platelet/lymphocyte
(PLR)
systemic
immune
inflammation
index
(SII)
examined
subjects’
peripheral
blood
samples.
Estimated
glomerular
filtration
rate
<60
mL/min/1.73
m
2
was
defined
as
CKD.
Multivariable
logistic
regression
medication
model
performed
examine
associations
PA,
Results
associated
CKD,
20%
lower
OR
CKD
compared
inactive
(p=0.002)
2%
per
30
min
moderate-to-vigorous
increase
(p=0.027).
also
significant
39%
higher
for
high
(p<0.001),
3%
(p<0.001).
NLR
SII
both
significantly
mediated
explained
1.87%
(medication
effect:
−0.0003,
direct
−0.0162)
2.73%
0.0005,
0.0192)
respectively.
While
1.77%
1.22%
0.0002,
0.0199)
The
results
did
not
show
any
statistical
between
PLR
this
sample.
Conclusion
finding
revealed
increasing
shortening
may
be
effective
strategies
prevention
early
management
through
regulation
inflammation.
only
prognostic
indicators
but
novel
potential
markers
predicting
occurrence.
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 10585 - 10598
Published: Dec. 1, 2024
Purpose:
This
study
identified
factors
that
identification
of
progression-predicting
utility
from
steroid-sensitive
nephrotic
syndrome(SSNS)
to
steroid-dependent
or
frequently
relapsing
syndrome
(SDNS/FRNS)
in
patients
and
developed
a
corresponding
predictive
model.
Patients
Methods:
retrospective
analyzed
clinical
data
756
aged
1
18
years,
diagnosed
with
SSNS,
who
received
treatment
at
the
Department
Nephrology,
Children's
Hospital
Chongqing
Medical
University,
between
November
2007
May
2023.
We
shrinkage
selection
operator
(LASSO)
-
logistic
regression
model,
which
was
visualized
using
nomogram.
The
model's
performance,
validity,
were
evaluated
through
receiver
operating
characteristic
curve
analysis,
confusion
matrix,
calibration
plot,
decision
analysis.
Results:
platelet-to-lymphocyte
ratio
(PLR)
as
an
independent
risk
factor
for
progression,
odds
(OR)
1.01
(95%
confidence
interval
(CI)
=
1.01–
1.01,
p
0.009).
Additionally,
other
significant
included
time
urinary
protein
turned
negative
(OR
1.17,
95%
CI
1.12–
1.23,
<
0.001),
estimated
glomerular
filtration
rate(eGFR)
0.99,
0.98–
low-density
lipoprotein
0.90,
0.83–
0.97,
0.006),
thrombin
1.22,
1.07–
1.39,
0.003),
neutrophil
absolute
counts
1.10,
1.02–
1.18,
performance
assessed
internal
validation,
yielding
area
under
0.78
(0.73–
0.82)
training
set
0.81
(0.75–
0.87)
validation
set.
Conclusion:
PLR,
eGFR,
negative,
lipoprotein,
time,
may
be
effective
predictors
identifying
SSNS
progressing
SDNS/FRNS.
These
findings
offer
valuable
insights
early
detection
support
use
precision
medicine
strategies
managing
Keywords:
LASSO,
SDNS/FRNS,
nomogram,
prediction
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 10, 2024
Inflammation
is
key
to
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
development.
Nevertheless,
the
correlation
between
inflammatory
marker,
neutrophil-to-lymphocyte
ratio
(NLR),
and
MASLD
prognosis
remains
unclear.
We
aim
determine
link
NLR
mortality
risk
in
MASLD.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Abstract
This
study
assessed
the
association
between
Chronic
Kidney
Disease
(CKD)
and
presbycusis
to
investigate
whether
inflammatory
neutrophil
percentage-to-albumin
ratio
(NPAR)
indicators
influence
this
relationship.This
used
data
from
National
Health
Nutrition
Examination
Surve
employed
such
as
restricted
cubic
spline
analysis,
multiple
logistic
regression
analyses
mediation
explore
these
relationships.High-frequency
Hearing
Impairment(HI)
was
correlated
with
moderate
CKD
(OR
=
3.25,
95%
CI
1.25–8.46,
P
0.02).
HI
grades
were
[for
slight
HI,
5.13,
1.48–17.86,
0.01);
for
severe
4.68,
1.29–17.04,
0.02)].
Mediation
analysis
revealed
that
NPAR
had
a
17.85%
mediating
effect
on
presbycusis.Moderate
associated
high-frequency
in
elderly
significant
relationship.
