Cited by N-Pep-Zn Improves Cognitive Functions and Acute Stress Response Affected by Chronic Social Isolation in Aged Spontaneously Hypertensive Rats (SHRs)

Rapid shift of gut microbiome and enrichment of beneficial microbes during arhatic yoga meditation retreat in a single-arm pilot study DOI

Sanjay Swarup, Abhishek Gupta, Mei Chung

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 13, 2025

The human microbiome plays a vital role in health, mediated by the gut–brain axis, with large diversity of functions and physiological benefits. dynamics mechanisms meditations on oral gut modulations are not well understood. This study investigates short-term during an Arhatic Yoga meditation retreat as improving well-being through possible gut-brain axis. A single-arm pilot clinical trial was conducted controlled environment 9-day intensive practices vegetarian diet. Oral fecal samples 24 practitioners were collected at start (Day0: T1), middle (Day3: T2), end (Day9:T3) retreat. Targeted 16S rRNA gene amplicon sequencing performed for both samples. Functional pathway predictions identified using phylogenetic investigation communities reconstruction unobserved states (PICRUSt2). DESeq2 used to identify differential abundant taxa. Various statistical analyses assess significant changes data. Our findings revealed that together diet led profiles within profile showed (p < 0.05) difference species richness evenness study, while non-metric multidimensional scaling (NMDS) confirmed shift T2 timepoint, which further supported PERMANOVA analysis 0.05). Health-benefiting microbes known improve gastrointestinal gut-barrier functions, immune modulation, axis enriched. Gut beginner advanced similar trends convergence study. implies strong selection pressure beneficial microbiome. demonstrates combined short resulted enrichment health-promoting microbes. Such microbial consortia may be developed potential health benefits probiotics systems, Study submitted https://clinicaltrials.gov/on28-02-2024 . Retrospective registered.

Language: Английский

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Microbiota–Gut–Brain Axis: Mass-Spectrometry-Based Metabolomics in the Study of Microbiome Mediators—Stress Relationship DOI

Nicolò Interino,

Rosalba Vitagliano,

Federica D’Amico

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 243 - 243

Published: Feb. 7, 2025

The microbiota-gut-brain axis is a complex bidirectional communication system that involves multiple interactions between intestinal functions and the emotional cognitive centers of brain. These are mediated by molecules (metabolites) produced in both areas, which considered mediators. To shed light on this mechanism, still largely unknown, reliable characterization mediators essential. Here, we review most studied metabolites axis, metabolic pathways they involved, their functions. This focuses mainly use mass spectrometry for determination, reporting latest analytical methods, limitations, future perspectives. strategy qualitative-quantitative must be order to elucidate molecular mechanisms underlying influence above-mentioned stress resilience or vulnerability.

Language: Английский

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Vascular Dementia: from Pathogenesis to Treatment DOI

Mingyue Cui, Leilei Wang, Tingting Wang

et al.

Journal of Contemporary Medical Practice, Journal Year: 2025, Volume and Issue: 7(2), P. 164 - 169

Published: Feb. 28, 2025

Vascular dementia is the second most common type of and a preventable disease, but its complex etiology difficult diagnosis make it occupy high status in field neuroscience geriatrics. At present, modern medicine mainly takes oral donepezil other drugs to control vascular risk factors improve cognitive function (non-) drugs; summarizes epidemiology, related factors, pathogenesis, treatment plan future direction dementia.

Language: Английский

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Vitamin D3 affects the gut metabolomics in lipopolysaccharide-injected mice DOI

Qian Xu,

Qi Geng, Yuan Liu

et al.

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Background: Although vitamin D3 (VD3) may regulate gut microbiota to play protective roles in systemic inflammation, its effects on metabolomics have not been clarified. Objective: To investigate the of VD3 LPS-injected mice. Methods: After mice were intervened with VD3, colon contents collected for an untargeted analysis, morphology and permeability epithelium illustrated. Results: The results confirmed against inflammatory changes hyperpermeability In metabolomic analysis contents, principal component showed valid data. Both partial least squares-discriminant (PLS-DA) orthogonal PLS-DA (OPLS-DA) intergroup separation samples between control Similarly, affected metabolite profiling composition mice, which also shown by OPLS-DA. Furthermore, differential metabolites identified univariate statistical analysis. For LPS stimulation, changed obviously, such as some lipid-related appeared increase. However, treatment had distinctive metabolomics, especially induced appearance Soyasaponins, reduction metabolites. Conclusions: alleviated injuries

Language: Английский

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Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders DOI

Mohammed Al‐Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy

et al.

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

BACKGROUND Functional gastrointestinal disorders (FGIDs) in children present with chronic symptoms like abdominal pain, diarrhea, and constipation without identifiable structural abnormalities. These are closely linked to gut-brain axis dysfunction, altered gut microbiota, psychosocial stress, leading psychiatric comorbidities such as anxiety, depression, behavioral issues. Understanding this bidirectional relationship is crucial for developing effective, holistic management strategies that address physical mental health. AIM To examine the impacts of FGIDs children, focusing on anxiety depression their association other neurodevelopmental childhood, attention-deficit/hyperactivity disorder, emphasizing role axis, emotional dysregulation, stress. Key mechanisms explored include neurotransmitter microbiota imbalance, central sensitization, heightening stress reactivity, symptom perception. The review also evaluates family dynamics coping exacerbating FGID contributing conditions. METHODS A narrative was conducted using 328 studies sourced from PubMed, Scopus, Google Scholar, covering research published over past 20 years. Inclusion criteria focused examining diagnosis, mechanisms, comorbidities, factors pediatric populations. commonly affecting including functional constipation, irritable bowel syndrome, gastroesophageal reflux, cyclic vomiting were analyzed concerning psychological impacts. RESULTS highlights a strong connection between symptoms, mediated by dysregulated sensitization. physiological disruptions increase children’s vulnerability while - early-life trauma, maladaptive dynamics, ineffective intensify cycle distress. CONCLUSION Effective requires biopsychosocial approach integrating medical, psychological, dietary interventions. Parental education, early intervention, multidisciplinary care coordination critical mitigating long-term improving both health outcomes FGIDs.

Language: Английский

Citations

Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease Therapeutics DOI

Sakshi Anand, Pradeep Kumar,

Sevaram Singh

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: March 19, 2025

Language: Английский

Citations

Molecular and metabolic effects of chronic stress on health, aging and carcinogenesis DOI

G. V. Gerashchenko, M. A. Tukalo

Biopolymers and Cell, Journal Year: 2025, Volume and Issue: 41(1), P. 23 - 31

Published: April 14, 2025

Language: Английский

Citations

Effects of Climate Change on the Immune System: A Narrative Review DOI

Luisa Imberti, Giorgio Tiecco,

Jacopo Logiudice

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(4)

Published: April 1, 2025

ABSTRACT Background and Aims Human activities have greatly influenced global temperatures, leading to climate change warming. This narrative review aims explore the relationship between immune system, focusing on how environmental stressors can affect regulation, both hyperactivity suppression. Methods A comprehensive search was conducted in PubMed Google Scholar for peer‐reviewed studies published up June 2024. The terms included “climate change,” “human health,” “infection,” “immunity,” “disease.” Inclusion criteria were based relevance, originality, accessibility. Results Exposure elevated temperatures significantly impair system cells, an overproduction of signaling molecules that promote inflammation. Temperature fluctuations been shown influence various aspects adaptive response, including cell mobilization, antigen processing presentation, lymphocyte trafficking activation, functionality B T cells. Notably, some research suggests heat stress negatively impacts differentiation, replication, proportion, resulting decreased immunoglobulin cytokine production, contributing immunosuppression. Additionally, change‐related exposures compromise epithelial barriers skin, lungs, gut, microbial dysbiosis, dysregulation. Furthermore, factors such as temperature variations, humidity, air pollutant levels may exacerbate prevalence infectious diseases, measles HIV, with varying acute, chronic, latent infections, further variability. Conclusion Climate change, particularly increased function, heightened inflammatory responses, Future should focus developing sustainable management strategies enhance health resilience face ongoing climatic changes.

Language: Английский

Citations

Probiotics as a Treatment of Chronic Stress Associated Abnormalities DOI

Vipul Agarwal, Rishabh Chaudhary,

Anugya Gupta

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

Galactooligosaccharides Attenuate Behavioural, Haematological and Immunological Abnormalities and Influence Gut Microbiota in Rats with Amygdala Hyperactivation Induced by Electrical Stimulation DOI

Jan Ruciński, E. Kurowska, Dorota Myślińska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4353 - 4353

Published: May 3, 2025

The amygdala, especially its central nucleus (CeA), is one of the key brain structures regulating fear, anxiety and stress responses also involved in gut microbiota signal processing. Amygdala hyperactivity, as well alterations, plays an important role pathophysiology disorders, depression or post-traumatic disorder (PTSD). present study determines whether 3 weeks galactooligosaccharide (GOS) supplementation alleviates behavioural, haematological, immunological disturbances induced by long-term electrical stimulation CeA rats (Stim). unsupplemented Stim group showed locomotor hyperactivity higher (measured with actometer elevated plus maze, respectively), a decrease white blood cells (WBCs), lymphocytes (LYMs), red (RBCs) platelets (PLTs); elevation TNFα; reduction IL-10 concentration plasma; alterations compared to control (Sham) group. GOS alleviated all these Stim-induced adverse effects even normalised them sham level. effect was comparable citalopram more effective WBC PLT normalisation induction. obtained results indicate high therapeutic potential stress-related disorders. may support conventional therapy prevention PTSD,

Language: Английский

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