Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2261 - 2261
Published: Oct. 4, 2024
Background/Objectives:
Aging
and
chronic
stress
are
regarded
as
the
most
important
risk
factors
of
cognitive
decline.
Aged
spontaneously
hypertensive
rats
(SHRs)
represent
a
suitable
model
age-related
vascular
brain
diseases.
The
aim
this
study
was
to
explore
effects
isolation
in
aging
SHRs
on
their
functions
response
acute
stress,
well
influence
oral
intake
N-Pep-Zn,
Zn
derivative
N-PEP-12.
Methods:
Nine-month-old
were
subjected
social
for
3
months
(SHRiso
group),
one
group
received
N-pep-Zn
orally
(SHRisoP,
1.5
mg/100
g
BW).
housed
groups
served
control
(SHRsoc).
behavioral
included
following
tests:
sucrose
preference,
open
field,
elevated
plus
maze,
three-chamber
sociability
novelty
spatial
learning
memory
Barnes
maze.
Levels
corticosterone,
glucose
proinflammatory
cytokines
blood
plasma
salivary
amylase
activity
measured.
Restraint
(60
min)
used
test
response.
Results:
Isolation
negatively
affected
while
treatment
isolated
with
N-Pep-Zn
improved
long-term
working
impairments,
making
SHRisoP
comparable
SHRsoc
group.
Acute
induced
decrease
relative
thymus
weight
SHRiso
(but
not
SHRsoc),
whereas
prevented
involution.
mitigated
increment
cortisol
levels
by
stress.
Conclusions:
enhanced
adaptive
capabilities
towards
(isolation)
(immobilization)
aged
disturbances
isolation,
probably
affecting
hypothalamo–pituitary–adrenal,
sympathetic,
immune
systems.
BMC Complementary Medicine and Therapies,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 13, 2025
The
human
microbiome
plays
a
vital
role
in
health,
mediated
by
the
gut–brain
axis,
with
large
diversity
of
functions
and
physiological
benefits.
dynamics
mechanisms
meditations
on
oral
gut
modulations
are
not
well
understood.
This
study
investigates
short-term
during
an
Arhatic
Yoga
meditation
retreat
as
improving
well-being
through
possible
gut-brain
axis.
A
single-arm
pilot
clinical
trial
was
conducted
controlled
environment
9-day
intensive
practices
vegetarian
diet.
Oral
fecal
samples
24
practitioners
were
collected
at
start
(Day0:
T1),
middle
(Day3:
T2),
end
(Day9:T3)
retreat.
Targeted
16S
rRNA
gene
amplicon
sequencing
performed
for
both
samples.
Functional
pathway
predictions
identified
using
phylogenetic
investigation
communities
reconstruction
unobserved
states
(PICRUSt2).
DESeq2
used
to
identify
differential
abundant
taxa.
Various
statistical
analyses
assess
significant
changes
data.
Our
findings
revealed
that
together
diet
led
profiles
within
profile
showed
(p
<
0.05)
difference
species
richness
evenness
study,
while
non-metric
multidimensional
scaling
(NMDS)
confirmed
shift
T2
timepoint,
which
further
supported
PERMANOVA
analysis
0.05).
Health-benefiting
microbes
known
improve
gastrointestinal
gut-barrier
functions,
immune
modulation,
axis
enriched.
Gut
beginner
advanced
similar
trends
convergence
study.
implies
strong
selection
pressure
beneficial
microbiome.
demonstrates
combined
short
resulted
enrichment
health-promoting
microbes.
Such
microbial
consortia
may
be
developed
potential
health
benefits
probiotics
systems,
Study
submitted
https://clinicaltrials.gov/on28-02-2024
.
Retrospective
registered.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 243 - 243
Published: Feb. 7, 2025
The
microbiota-gut-brain
axis
is
a
complex
bidirectional
communication
system
that
involves
multiple
interactions
between
intestinal
functions
and
the
emotional
cognitive
centers
of
brain.
These
are
mediated
by
molecules
(metabolites)
produced
in
both
areas,
which
considered
mediators.
To
shed
light
on
this
mechanism,
still
largely
unknown,
reliable
characterization
mediators
essential.
Here,
we
review
most
studied
metabolites
axis,
metabolic
pathways
they
involved,
their
functions.
This
focuses
mainly
use
mass
spectrometry
for
determination,
reporting
latest
analytical
methods,
limitations,
future
perspectives.
strategy
qualitative-quantitative
must
be
order
to
elucidate
molecular
mechanisms
underlying
influence
above-mentioned
stress
resilience
or
vulnerability.
Journal of Contemporary Medical Practice,
Journal Year:
2025,
Volume and Issue:
7(2), P. 164 - 169
Published: Feb. 28, 2025
Vascular
dementia
is
the
second
most
common
type
of
and
a
preventable
disease,
but
its
complex
etiology
difficult
diagnosis
make
it
occupy
high
status
in
field
neuroscience
geriatrics.
At
present,
modern
medicine
mainly
takes
oral
donepezil
other
drugs
to
control
vascular
risk
factors
improve
cognitive
function
(non-)
drugs;
summarizes
epidemiology,
related
factors,
pathogenesis,
treatment
plan
future
direction
dementia.
Mediterranean Journal of Nutrition and Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 2, 2025
Background:
Although
vitamin
D3
(VD3)
may
regulate
gut
microbiota
to
play
protective
roles
in
systemic
inflammation,
its
effects
on
metabolomics
have
not
been
clarified.
Objective:
To
investigate
the
of
VD3
LPS-injected
mice.
Methods:
After
mice
were
intervened
with
VD3,
colon
contents
collected
for
an
untargeted
analysis,
morphology
and
permeability
epithelium
illustrated.
Results:
The
results
confirmed
against
inflammatory
changes
hyperpermeability
In
metabolomic
analysis
contents,
principal
component
showed
valid
data.
Both
partial
least
squares-discriminant
(PLS-DA)
orthogonal
PLS-DA
(OPLS-DA)
intergroup
separation
samples
between
control
Similarly,
affected
metabolite
profiling
composition
mice,
which
also
shown
by
OPLS-DA.
Furthermore,
differential
metabolites
identified
univariate
statistical
analysis.
For
LPS
stimulation,
changed
obviously,
such
as
some
lipid-related
appeared
increase.
However,
treatment
had
distinctive
metabolomics,
especially
induced
appearance
Soyasaponins,
reduction
metabolites.
Conclusions:
alleviated
injuries
World Journal of Clinical Pediatrics,
Journal Year:
2025,
Volume and Issue:
14(2)
Published: March 18, 2025
BACKGROUND
Functional
gastrointestinal
disorders
(FGIDs)
in
children
present
with
chronic
symptoms
like
abdominal
pain,
diarrhea,
and
constipation
without
identifiable
structural
abnormalities.
These
are
closely
linked
to
gut-brain
axis
dysfunction,
altered
gut
microbiota,
psychosocial
stress,
leading
psychiatric
comorbidities
such
as
anxiety,
depression,
behavioral
issues.
Understanding
this
bidirectional
relationship
is
crucial
for
developing
effective,
holistic
management
strategies
that
address
physical
mental
health.
AIM
To
examine
the
impacts
of
FGIDs
children,
focusing
on
anxiety
depression
their
association
other
neurodevelopmental
childhood,
attention-deficit/hyperactivity
disorder,
emphasizing
role
axis,
emotional
dysregulation,
stress.
Key
mechanisms
explored
include
neurotransmitter
microbiota
imbalance,
central
sensitization,
heightening
stress
reactivity,
symptom
perception.
The
review
also
evaluates
family
dynamics
coping
exacerbating
FGID
contributing
conditions.
METHODS
A
narrative
was
conducted
using
328
studies
sourced
from
PubMed,
Scopus,
Google
Scholar,
covering
research
published
over
past
20
years.
Inclusion
criteria
focused
examining
diagnosis,
mechanisms,
comorbidities,
factors
pediatric
populations.
commonly
affecting
including
functional
constipation,
irritable
bowel
syndrome,
gastroesophageal
reflux,
cyclic
vomiting
were
analyzed
concerning
psychological
impacts.
RESULTS
highlights
a
strong
connection
between
symptoms,
mediated
by
dysregulated
sensitization.
physiological
disruptions
increase
children’s
vulnerability
while
-
early-life
trauma,
maladaptive
dynamics,
ineffective
intensify
cycle
distress.
CONCLUSION
Effective
requires
biopsychosocial
approach
integrating
medical,
psychological,
dietary
interventions.
Parental
education,
early
intervention,
multidisciplinary
care
coordination
critical
mitigating
long-term
improving
both
health
outcomes
FGIDs.
Health Science Reports,
Journal Year:
2025,
Volume and Issue:
8(4)
Published: April 1, 2025
ABSTRACT
Background
and
Aims
Human
activities
have
greatly
influenced
global
temperatures,
leading
to
climate
change
warming.
This
narrative
review
aims
explore
the
relationship
between
immune
system,
focusing
on
how
environmental
stressors
can
affect
regulation,
both
hyperactivity
suppression.
Methods
A
comprehensive
search
was
conducted
in
PubMed
Google
Scholar
for
peer‐reviewed
studies
published
up
June
2024.
The
terms
included
“climate
change,”
“human
health,”
“infection,”
“immunity,”
“disease.”
Inclusion
criteria
were
based
relevance,
originality,
accessibility.
Results
Exposure
elevated
temperatures
significantly
impair
system
cells,
an
overproduction
of
signaling
molecules
that
promote
inflammation.
Temperature
fluctuations
been
shown
influence
various
aspects
adaptive
response,
including
cell
mobilization,
antigen
processing
presentation,
lymphocyte
trafficking
activation,
functionality
B
T
cells.
Notably,
some
research
suggests
heat
stress
negatively
impacts
differentiation,
replication,
proportion,
resulting
decreased
immunoglobulin
cytokine
production,
contributing
immunosuppression.
Additionally,
change‐related
exposures
compromise
epithelial
barriers
skin,
lungs,
gut,
microbial
dysbiosis,
dysregulation.
Furthermore,
factors
such
as
temperature
variations,
humidity,
air
pollutant
levels
may
exacerbate
prevalence
infectious
diseases,
measles
HIV,
with
varying
acute,
chronic,
latent
infections,
further
variability.
Conclusion
Climate
change,
particularly
increased
function,
heightened
inflammatory
responses,
Future
should
focus
developing
sustainable
management
strategies
enhance
health
resilience
face
ongoing
climatic
changes.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4353 - 4353
Published: May 3, 2025
The
amygdala,
especially
its
central
nucleus
(CeA),
is
one
of
the
key
brain
structures
regulating
fear,
anxiety
and
stress
responses
also
involved
in
gut
microbiota
signal
processing.
Amygdala
hyperactivity,
as
well
alterations,
plays
an
important
role
pathophysiology
disorders,
depression
or
post-traumatic
disorder
(PTSD).
present
study
determines
whether
3
weeks
galactooligosaccharide
(GOS)
supplementation
alleviates
behavioural,
haematological,
immunological
disturbances
induced
by
long-term
electrical
stimulation
CeA
rats
(Stim).
unsupplemented
Stim
group
showed
locomotor
hyperactivity
higher
(measured
with
actometer
elevated
plus
maze,
respectively),
a
decrease
white
blood
cells
(WBCs),
lymphocytes
(LYMs),
red
(RBCs)
platelets
(PLTs);
elevation
TNFα;
reduction
IL-10
concentration
plasma;
alterations
compared
to
control
(Sham)
group.
GOS
alleviated
all
these
Stim-induced
adverse
effects
even
normalised
them
sham
level.
effect
was
comparable
citalopram
more
effective
WBC
PLT
normalisation
induction.
obtained
results
indicate
high
therapeutic
potential
stress-related
disorders.
may
support
conventional
therapy
prevention
PTSD,