Enhancing Herd Immunity: The Indirect Immune Effects of the M. bovis‐BoHV‐1 Combined Vaccine

Transboundary and Emerging Diseases, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Bovine respiratory disease (BRD) is a complex illness driven by the interplay of various bacteria and viruses, often resulting in co‐infection. It stands as one most significant costly challenges cattle industry. The development vaccines targeting BRD pathogens has garnered substantial attention, particularly for their ability to induce indirect immune protection unvaccinated animals through effects vaccinated individuals. In this study, we comprehensively evaluated effect our developed attenuated marker Mycoplasma bovis ‐BoHV‐1 combined vaccine. Our results demonstrated that vaccine effectively activates innate response cohabitating with immunized This was evidenced increase serum lysozyme levels, blood lymphocyte counts, elevated cytokine levels. Furthermore, these exhibited effective activation humoral response, indicated levels specific antibodies against pathogens. Notably, M. ELISA BoHV‐1 neutralizing all calves from co‐housing group turned positive second week, exceeding threshold values 41% 1:8, respectively. addition, total IgA IgG were significantly compared blank control group. conclusion, shows notable effect, which essential controlling spread infection enhancing calf survival. study greatly facilitated sustainable growth

Language: Английский

Effects of vaccination and interventions on nasal microbiome and BRD-associated pathogens in calves

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Vaccination is a widely adopted measure to prevent diseases, but the process of immunization can induce substantial stress response. This study aimed investigate impact combined Mycoplasma bovis -BoHV-1 vaccine on upper respiratory tract microbiome and BRD-associated pathogens in calves, as well evaluate effects potential interventions. The results showed that percentage Pasteurella species was elevated calves after vaccination without intervention, multocida activated proliferated. Interestingly, none three interventions (Sodium selenite-vitamin E, Astragalus polysaccharide Ceftiofur sodium) affected antibody production immunization. administration sodium E astragalus reduced serum levels cortisol malondialdehyde, increased glutathione peroxidase (GSH-Px) superoxide dismutase (SOD), alleviated proliferation . Furthermore, use ceftiofur almost completely inhibited induced by immune stress. These findings provide reference for mitigating negative impacts associated with highlight benefits using targeted nutritional antimicrobial optimize responses maintain stable calves.

Language: Английский