m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease DOI Creative Commons

Sisi Teng,

Cunqiao Han,

Jian Zhou

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 8, 2024

Alzheimer’s disease (AD) is a neurodegenerative disorder caused by variety of factors, including age, genetic susceptibility, cardiovascular disease, traumatic brain injury, and environmental factors. The pathogenesis AD largely associated with the overproduction accumulation amyloid-β peptides hyperphosphorylation tau protein in brain. Recent studies have identified presence diverse pathogens, viruses, bacteria, parasites, tissues patients, underscoring critical role central nervous system infections inducing pathological changes AD. Nevertheless, it remains unestablished about specific mechanism which lead to occurrence As an important post-transcriptional RNA modification, 5-methylcytosine (m 5 C) methylation regulates wide range biological processes, splicing, nuclear export, stability, translation, therefore affecting cellular function. Moreover, has been recently demonstrated that multiple pathogenic microbial are m C host. However, infectious still uncertain. Therefore, this review discusses mechanisms pathogen-induced summarizes research on molecular AD, thereby providing new insight into exploring underlying

Language: Английский

Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection DOI Creative Commons
Rajnish Kumar Singh,

Vangala Ramakrishna,

Atharva S. Torne

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Oncogenic gamma herpesviruses, including Epstein-Barr Virus (EBV) and Kaposi's Sarcoma-associated Herpesvirus (KSHV), are opportunistic cancer-causing viruses induces oncogenesis through complex mechanisms, which involves manipulation of cellular physiology as well epigenetic epitranscriptomic reprogramming. In this review, we describe the intricate processes by these interact with machinery, leading to alterations in DNA methylation, histone modifications, involvement non-coding RNAs. The key viral proteins such EBNA1 LMP1 encoded EBV; LANA vGPCR KSHV; play pivotal roles modifications interacting host factors, dysregulating signaling pathways. resultant reprogramming can lead activation oncogenes, silencing tumor suppressor genes, evasion immune response, ultimately contributes oncogenic potential viruses. Furthermore, explore current therapeutic strategies targeting discuss future directions for research treatment. Through comprehensive examination mechanisms employed aim provide valuable insights into avenues novel interventions.

Language: Английский

Citations

0
m5C methylation modification may be an accomplice in colorectal cancer escaping from anti-tumor effects of innate immunity-type I/III interferon DOI Creative Commons

Yiqi Sun,

Yunfei Liu, Lu Jiang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Colorectal cancer (CRC) is one of the most prevalent malignant tumors in world, and its occurrence development are closely related to complex immune regulatory mechanisms. As first barrier body's defense, innate immunity plays a key role tumor surveillance anti-tumor response, which type I/III interferon (IFN) an important mediator with significant antiviral functions. 5-methylcytosine (m5C) modification RNA epigenetic regulation that promotes expression CRC oncogenes immune-related genes. It can enhance proliferation, migration, invasion cells by affecting mRNA stability, translation efficiency, nuclear export. In addition, m5C modulates activity signaling pathways inhibits production function, further helping evade surveillance. However, there insufficient elucidations on interaction between CRC. this study, mechanism colorectal was systematically reviewed explored. This work focused how escape pathway, thereby providing new diagnostic markers therapeutic targets for clinical use, enhancing immunotherapy efficacy.

Language: Английский

Citations

0
NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA DOI Creative Commons
Zhilong Li,

Wu Xianzhen

Thoracic Cancer, Journal Year: 2025, Volume and Issue: 16(5)

Published: March 1, 2025

5-methylcytosine (m5C) methylation is the crucial posttranscriptional modification of RNA. NSUN4, a methyltransferase for m5C methylation, contributes to lung tumorigenesis. Here, we determined precise action NSUN4 on development non-small cell cancer (NSCLC). and CDC20 mRNA expression was detected by quantitative PCR. Western blot immunohistochemistry were used analysis protein expression. Cell growth, apoptosis, invasiveness, migratory ability, stemness potential evaluated colony formation, flow cytometry, transwell, sphere formation assays. The influence in analyzed using RNA immunoprecipitation (RIP) assay Actinomycin D (Act D) treatment. Subcutaneous xenograft studies performed analyze function vivo. In human NSCLC tumors lines, levels upregulated. inhibition diminished stemness, ability vitro, while increase had opposite effects. A positive association between observed samples. Mechanistically, enhanced stability through modification. depletion significantly counteracted NSUN4-driven phenotype alterations vitro. Additionally, impeded growth A549 subcutaneous xenografts Our findings identify pro-tumorigenic property NSUN4/CDC20 cascade NSCLC. Targeting novel may be promising way combating this deadly disease.

Language: Английский

Citations

0
RNA methylation: A new perspective in osteoarthritis research DOI

Guihao Zheng,

Mengji Lu,

Yulong Ouyang

et al.

Gene, Journal Year: 2025, Volume and Issue: 959, P. 149518 - 149518

Published: April 18, 2025

Language: Английский

Citations

0
RNA m5C modification: from physiology to pathology and its biological significance DOI Creative Commons
Xi Chen,

Yixiao Yuan,

Fan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

RNA 5-methylcytosine (m5C) modification is a crucial epitranscriptomic mark that regulates stability, processing, and translation. Emerging evidence highlights its essential role in various physiological processes, including cellular differentiation, stem cell maintenance, immune responses. Dysregulation of m5C has been implicated multiple pathological conditions, particularly cancer, neurodegenerative disorders, metabolic diseases. This review provides comprehensive overview the molecular mechanisms governing deposition, functional consequences normal physiology, contributions to disease pathogenesis. Furthermore, we discuss potential as biomarker therapeutic target, offering new insights into biological significance clinical relevance.

Language: Английский

Citations

0
Mechanism of Puerarin Alleviating Myocardial Remodeling through NSUN2-Mediated m5C Methylation Modification DOI

Wu Yahua,

Xiaomin Huang, Yun He

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156849 - 156849

Published: May 1, 2025

Language: Английский

Citations

0
m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease DOI Creative Commons

Sisi Teng,

Cunqiao Han,

Jian Zhou

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 8, 2024

Alzheimer’s disease (AD) is a neurodegenerative disorder caused by variety of factors, including age, genetic susceptibility, cardiovascular disease, traumatic brain injury, and environmental factors. The pathogenesis AD largely associated with the overproduction accumulation amyloid-β peptides hyperphosphorylation tau protein in brain. Recent studies have identified presence diverse pathogens, viruses, bacteria, parasites, tissues patients, underscoring critical role central nervous system infections inducing pathological changes AD. Nevertheless, it remains unestablished about specific mechanism which lead to occurrence As an important post-transcriptional RNA modification, 5-methylcytosine (m 5 C) methylation regulates wide range biological processes, splicing, nuclear export, stability, translation, therefore affecting cellular function. Moreover, has been recently demonstrated that multiple pathogenic microbial are m C host. However, infectious still uncertain. Therefore, this review discusses mechanisms pathogen-induced summarizes research on molecular AD, thereby providing new insight into exploring underlying

Language: Английский

Citations

2