International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113918 - 113918
Published: Dec. 22, 2024
Language: Английский
MedComm, Journal Year: 2024, Volume and Issue: 5(9)
Published: Sept. 1, 2024
Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.
Language: Английский
Citations
14
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3349 - 3360
Published: March 1, 2025
Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation Gasdermin proteins, which membrane pores, leading to rapid rupture and release inflammatory molecules. Unlike other types death, pyroptosis has distinct mechanisms plays complex role in chronic intestinal diseases, including bowel disease, fibrosis, infectious enteritis, colorectal cancer. This review comprehensively examines how influences disease development progression while exploring therapeutic potential targeting pyroptosis-related pathways. Moreover, interplay between gut microbiota summarized, highlighting its critical pathogenesis disorders. A deeper understanding these diseases may provide valuable insights for future research contribute innovative strategies gastroenterology.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101191 - 101191
Published: Aug. 7, 2024
Contemporary progress in tumor immunotherapy has solidified its role as an effective approach combating cancer. Nonetheless, the prevalent "immune cold" state within microenvironment poses a substantial barrier to efficacy. Addressing this, pyroptosis-a gasdermin-mediated programmed cell death characterized by inflammatory profile-emerges crucial mechanism. It catalyzes release of vast quantities pro-inflammatory cytokines and immunogens, potentially transforming immunosuppressive "cold" tumors into reactive "hot" ones. Herein, we will initially present overview pyroptosis distinct form death, along with molecular mechanisms. Subsequently, focus on introducing how activators are utilized field immunotherapy. Insights gained from applications could lead development safe efficient activators, significantly enriching arsenal for
Language: Английский
Citations
2
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113918 - 113918
Published: Dec. 22, 2024
Language: Английский
Citations
1