Sex-Specific Impact of Inflammation and Nutritional Indices on AVF Blood Flow and Maturation: A Retrospective Analysis DOI Creative Commons
Özgür Akkaya, Ümit Arslan

Diagnostics, Journal Year: 2025, Volume and Issue: 15(10), P. 1278 - 1278

Published: May 18, 2025

Background: Arteriovenous fistula (AVF) failure rates are consistently higher in females, although the underlying mechanisms remain incompletely understood. Inflammatory processes play a key role AVF remodeling and venous arterialization, yet their influence may differ by sex. This study aimed to evaluate impact of inflammatory indices on blood flow maturation, with focus sex-specific differences. Methods: retrospective analytical included 110 patients (50 60 males) undergoing initial surgical creation. Postoperative assessments occurred at fourth sixth weeks. Patients demonstrating insufficient maturation (blood < 600 mL/min) week were re-evaluated after two weeks without any intervening procedures or additional interventions. Results: Intraoperative Transit-Time Flow Measurement (TTFM) revealed significantly median males compared females (289 mL/min vs. 200 mL/min; p 0.001). Doppler ultrasonography (DUS) findings confirmed these sex-related differences, lower female patients. An elevated neutrophil-to-lymphocyte ratio (NLR) was associated approximately 31% reduction among whereas an increased C-reactive protein-to-albumin (CrA) correlated approximate 9% decline. In males, systemic immune-inflammation index (SII) inflammation response (SIRI) decreased flow. Conversely, prognostic nutritional (PNI) positively both sexes. Risk factors inadequate (<600 week) sex, advanced age, obesity, smoking, anemia, low vitamin D levels, (NLR, SII, SIRI). Conclusions: derived from routine laboratory tests assist estimating likelihood. While DUS reliably assesses flow, complementary evaluation methods be required assess broader vascular status. Further research is needed clarify influencing outcomes guide individualized management strategies.

Language: Английский

Predictive ability of systemic coagulation-inflammation index on early fistula failure after radiocephalic arteriovenous fistula creation DOI
Mustafa Selçuk Atasoy, Ayhan Muduroglu

The International Journal of Artificial Organs, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Introduction: To the best of our knowledge, a possible predictive relationship between systemic coagulation-inflammation index (SCI) and arteriovenous fistula (AVF) failure following AVF creation has not yet been examined. We therefore designed this study to examine ability SCI on postoperative early in patients undergoing primary radiocephalic operation. Methods: A total 189 who underwent operation for hemodialysis access were included retrospective observational cohort study, then divided into two groups according whether occurred within first 3 months after operation; as failed group ( n = 44) non-failed 145). The patients’ baseline clinical characteristics laboratory parameters recorded compared groups. Results: Patients significantly older had higher smoking rate than those AF group. median values fibrinogen, platelet-to-lymphocyte ratio With regards other parameters, no significant differences detected univariate analyses. Only age maintained their significances multivariate logistic regression analysis, considered independent predictors failure. ROC curve analysis revealed that 37.9 constituted optimum cut-off value with 97.7% sensitivity 94.5% specificity rates predicting Conclusion: present demonstrated time literature independently predicted creation.

Language: Английский

Citations

0
Progress in the application of novel inflammatory indicators in chronic kidney disease DOI Creative Commons

Wei Gao,

Xiangyu Wang, Yulin Zou

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Chronic kidney disease has become a public health problem endangering the of all humans because its high prevalence, mortality and medical burden. The chronic micro-inflammatory state is recognized as significant component CKD, playing key role in progression. Intervening inflammation during course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte systemic immune-inflammatory index are closely associated with meanwhile may serve prognostic monitors all-cause death poor renal prognosis for disease. This article comprehensively reports on mechanisms micro-inflammation relationship between indicators their impact

Language: Английский

Citations

0
Development and Validation of Interpretable Machine Learning Models To Predict Intensive Care Unit Outcomes in Patients on Hemodialysis: A Multicenter Study DOI
Minjie Chen,

P. K.-T. Li,

Yuanwen Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Association between systemic coagulation-inflammation index and proximal upper-extremity arteriovenous graft thrombosis in hemodialysis patients DOI Creative Commons
Demir Çetintaş, Hakan Güven

The International Journal of Artificial Organs, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

To the best of our knowledge, potential predictive association between systemic coagulation-inflammation index (SCI) and arteriovenous graft (AVG) thrombosis following proximal upper-extremity AVG surgery has not yet been investigated. Thus, in this study, we investigated value SCI on postoperative early-term patients undergoing for hemodialysis access. A total 118 were enrolled to retrospective observational cohort study. The categorized into two groups accordance with whether developed; as thrombosed group (n = 37) non-thrombosed 81). Basic clinical features laboratory test results recorded compared groups. Patients significantly older than those group. mean WBC neutrophil counts lower whereas fibrinogen median values higher In terms other basic tests, there no significant differences both univariate analyses. multivariate logistic regression analysis, only age maintained their statistical significance thus accepted independent predictors thrombosis. ROC analysis demonstrated that 47 g/L constituted optimum cut-off 94.6% sensitivity 88.9% specificity rates predicting Our study revealed first time literature independently predicted surgery.

Language: Английский

Citations

0
Association between blood inflammatory status and the survival of tuberculosis: a five-year cohort study DOI Creative Commons
Yating Ji,

Qingyao Xie,

Wei Wei

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Background Blood inflammatory status is closely associated with tuberculosis (TB) progression. Emerging indices from different leukocyte subtypes have become a prognostic hotspot for various diseases, yet their application in TB prognosis remains limited. This study aims to assess the impact of on patients’ and its potential as indicator optimize assessment therapeutic strategies. Methods included 4027 patients admitted tuberculosis-designated hospital Shenzhen January 2017 December 2022. Patients were classified into three statuses (Q1-Q3) based each index’s level. We conducted Cox regression restricted cubic splines (RCS) analyses evaluate association between unfavorable outcome, subgroup understand heterogeneous associations among subpopulations, receiver operating characteristic (ROC) performance treatment outcomes. Results During 48991.79 person-months follow-up involving patients, 225 outcomes occurred. Multivariable indicated that Q3 levels CAR, CLR, dNLR, NLR, SII, SIRI increased risk outcome by 45%-99% (HR: 1.45-1.99, all P &lt;0.050), whereas ENR reduced 29% 0.71, =0.040) compared Q1. RCS curves revealed linear positive SIRI, negative (all nonlinear&gt;0.050), nonlinear MLR, PNI nonlinear&lt;0.050). Subgroup identified across age, sex, BMI, comorbidities, drug resistance interaction&lt;0.050), attenuated effects SII aged 30-60 years, male, BMI≥24.0 kg/m², smokers, retreatment cases, those tumor. ROC analysis demonstrated stable predictive performances (AUC: 0.785–0.804 at 6-month, 0.781–0.793 9-month, 0.762–0.773 12-month), combination significantly optimized basic model (9-month AUC: 0.811 vs 0.780, =0.024; 12-month 0.794 0.758, =0.013). Conclusion Pretreatment blood effectively predicts patients. Our findings hold significant clinical value patient management warrant prospective evaluation future studies.

Language: Английский

Citations

0
The association of immune-inflammation indices at multiple time points with treatment response and survival in advanced non-small cell lung cancer patients receiving immune checkpoint inhibitors DOI Creative Commons
Yaqing Li,

Xu Jianping,

Lijuan Zhang

et al.

World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 16, 2025

Immune and inflammation participate in the progression of non-small cell lung cancer (NSCLC) some immune-inflammation indexes may serve as prognostic biomarkers NSCLC patients. This study aimed to investigate association between indices at multiple time points prognosis advanced patients treated with immune checkpoint inhibitors (ICIs). retrospective included 102 ICIs collected their blood within 7 days before treatment (T1), 3rd cycle (T2), 5th (T3) calculate neutrophil-to-lymphocyte ratio (NLR), derived (dNLR), pan-immune-inflammatory value (PIV), systemic index (SII), nutritional (PNI), (LIPI). dNLR (P = 0.006), SII 0.005), PIV 0.010), LIPI 0.001) reduced, while PNI increased 0.009) from T1 T3; NLR was not different among T1, T2, T3 0.282). A lower 0.011) higher 0.026) T3, T2 0.023) were related better disease control rate, but these linked objective response rate any timepoint. Multivariate Cox regression analysis showed that high independently worse PFS (hazard ratio: 4.187, P 0.008), associated 0.454, 0.021). after treatment, well potential for or survival receiving ICIs.

Language: Английский

Citations

0
Sex-Specific Impact of Inflammation and Nutritional Indices on AVF Blood Flow and Maturation: A Retrospective Analysis DOI Creative Commons
Özgür Akkaya, Ümit Arslan

Diagnostics, Journal Year: 2025, Volume and Issue: 15(10), P. 1278 - 1278

Published: May 18, 2025

Background: Arteriovenous fistula (AVF) failure rates are consistently higher in females, although the underlying mechanisms remain incompletely understood. Inflammatory processes play a key role AVF remodeling and venous arterialization, yet their influence may differ by sex. This study aimed to evaluate impact of inflammatory indices on blood flow maturation, with focus sex-specific differences. Methods: retrospective analytical included 110 patients (50 60 males) undergoing initial surgical creation. Postoperative assessments occurred at fourth sixth weeks. Patients demonstrating insufficient maturation (blood < 600 mL/min) week were re-evaluated after two weeks without any intervening procedures or additional interventions. Results: Intraoperative Transit-Time Flow Measurement (TTFM) revealed significantly median males compared females (289 mL/min vs. 200 mL/min; p 0.001). Doppler ultrasonography (DUS) findings confirmed these sex-related differences, lower female patients. An elevated neutrophil-to-lymphocyte ratio (NLR) was associated approximately 31% reduction among whereas an increased C-reactive protein-to-albumin (CrA) correlated approximate 9% decline. In males, systemic immune-inflammation index (SII) inflammation response (SIRI) decreased flow. Conversely, prognostic nutritional (PNI) positively both sexes. Risk factors inadequate (<600 week) sex, advanced age, obesity, smoking, anemia, low vitamin D levels, (NLR, SII, SIRI). Conclusions: derived from routine laboratory tests assist estimating likelihood. While DUS reliably assesses flow, complementary evaluation methods be required assess broader vascular status. Further research is needed clarify influencing outcomes guide individualized management strategies.

Language: Английский

Citations

0