Regulation of innate lymphoid cell by microbial metabolites

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Mediating role of chiro-inositol metabolites on the effects of HLA-DR-expressing CD14 + monocytes in inflammatory bowel disease

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 17, 2024

Abstract Background Inflammatory bowel disease (IBD), a chronic inflammatory condition, is caused by several factors involving aberrant immune responses. Genetic are crucial in IBD occurrence. Mendelian randomization (MR) can offer new perspective understanding IBD’s genetic background. Methods Single nucleotide polymorphisms (SNPs) were considered instrumental variables (IVs). We analyzed the relationship between 731 immunophenotypes, 1,400 metabolite phenotypes, and IBD. The total effect was decomposed into indirect direct effects, ratio of to calculated. Results identified causal effects HLA-DR-expressing CD14 + monocytes on through MR analysis. phenotype “HLA-DR expression monocytes” showed strongest association among selected 48 phenotypes. Chiro-inositol metabolites mediated expressing HLA-DR An increase associated with reduced risk occurrence, accounting for 4.97%. Conclusion Our findings revealed pathway which indirectly occurrence increasing levels metabolites. results provided immunoregulatory mechanisms underlying IBD, laying theoretical foundation developing therapeutic targets future.

Language: Английский

The causal relationship between immune cell-mediated gut microbiota and ulcerative colitis: a bidirectional two-sample, mediation Mendelian randomization analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 25, 2024

Numerous studies have highlighted the close association between gut microbiota and development of ulcerative colitis (UC), yet research on whether immune cells mediate this process remains scarce. This study utilizes various Mendelian randomization (MR) methods to investigate causal relationship UC, further exploring mediating role in process.

Language: Английский