Recent insights and advances in gut microbiota's influence on host antiviral immunity

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

A diverse array of microbial organisms colonizes the human body, collectively known as symbiotic communities. Among various pathogen infections that hosts encounter, viral represent one most significant public health challenges worldwide. The gut microbiota is considered an important biological barrier against and may serve a promising target for adjuvant antiviral therapy. However, potential impact on infection remains relatively understudied. In this review, we discuss specific regulatory mechanisms in immunity, highlighting recent advances how regulate host immune response, produce immune-related molecules, enhance host's defense viruses. Finally, also oral probiotics.

Language: Английский

Organellar crosstalk as a potential therapeutic target for rare neurodegenerative diseases

Rare Disease and Orphan Drugs Journal, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 28, 2025

Organellar crosstalk has gained significant interest due to its essential role in maintaining cellular homeostasis and normal function. Conversely, disruptions organelles their interactions are increasingly recognized as key contributors the pathogenesis of numerous diseases. Rare neurodegenerative diseases, such Gaucher disease (GD) X-linked adrenoleukodystrophy (ALD), caused by inherited mutations that disrupt critical metabolic pathways. Genetic variants encoding proteins involved these pathways result excessive accumulation corresponding substrates, which subsequently trigger organellar dysfunction, often involving mitochondria, lysosomes, endoplasmic reticulum (ER), or peroxisomes. To date, specific mechanisms underlying roles pathophysiology respective diseases not fully elucidated, an area continues be actively studied. Understanding could reveal novel targets for future therapeutic development. Furthermore, severity rare lack effective treatments forpatients underscore urgency thorough investigations into crosstalk. This review provides overview between ER, peroxisomes lysosomal GD, peroxisomal disorders, including ALD. Additionally, we explore potential strategies targeting interconnected

Language: Английский

Diet-Induced mechanical stress promotes immune and metabolic alterations in the Drosophila melanogaster digestive tract

Journal of Invertebrate Pathology, Journal Year: 2025, Volume and Issue: unknown, P. 108348 - 108348

Published: May 1, 2025

Language: Английский