Shadows and lights in sepsis immunotherapy DOI
Guillaume Monneret,

Muzhda Haem Rahimi,

Anne‐Claire Lukaszewicz

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(16), P. 2125 - 2133

Published: Oct. 17, 2024

Introduction Sepsis remains a major global public health challenge. The host's response in sepsis involves both an exaggerated inflammatory reaction and immunosuppressive mechanisms. A better understanding of this has shed light on the failure anti-inflammatory therapies administered under 'one size fits all' approach during last decades.

Language: Английский

Endarachne binghamiae Extract Ameliorates Inflammatory Responses in Macrophages Through Regulation of MAPK, NF-kB and PI3K/AKT Pathways, and Prevents Acute Lung Injury in Mice DOI Creative Commons

Sang-Hoon Lee,

Sang-Seop Lee,

Ga‐Young Lee

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 88 - 88

Published: Jan. 13, 2025

In this study, the anti-inflammatory effect of hot water extract Endarachne binghamiae (EB-WE), a type marine brown algae, was investigated in LPS-stimulated RAW 264.7 cells and an acute lung injury (ALI) mouse model induced by intranasal LPS administration. Treatment with EB-WE significantly inhibited NO pro-inflammatory cytokine (TNF-a IL-6) production cells. mRNA analysis, expression cytokines, COX-2, iNOS mRNAs, down-regulated treatment. The phosphorylation MAPK, IkB, PI3K/AKT molecules responsible for signal pathways during inflammation macrophages also EB-WE. vivo ALI, oral administration reduced level cytokines (TNF-a, IL-1b, chemokines (MCP-1, CXC-16, CXCL1, TARC) serum or bronchoalveolar lavage fluid (BALF) mice. Similarly to results cells, treatment intracellular mediated tissues mice decreased mRNAs inflammatory mediators such as TNF-a, IL-6, iNOS, COX-2. Furthermore, inhibitory on ALI apparently confirmed histological examination through tissue staining. Taken together, it is clear that has potential activity effectively ameliorate responses down-regulation NF-kB, activation, suppress LPS. These findings strongly suggest promising natural product beneficial developing preventive treatments cures inflammation-related diseases.

Language: Английский

Citations

0
ITGB2 and ICAM3 predict increased survival of sepsis with decreased intercellular communication in cytotoxic CD8+ T cells DOI Creative Commons
Min Lei, Yaping Zhang, Yijin Yu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Language: Английский

Citations

0
Cycloastragenol Reduces Inflammation in CLP-induced Septic Mice by Suppressing TLR4 Signaling Pathways DOI
Guang‐Hong Chen, Weihong Wang, Baoyi Guan

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156645 - 156645

Published: March 13, 2025

Language: Английский

Citations

0
A Tetrahedral Framework DNA-Based Bioswitchable miR-150 Delivery System for Sepsis DOI

Yutian He,

Zhi‐Qiang Liu, Songhang Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58477 - 58488

Published: Oct. 18, 2024

Sepsis is a disease with high morbidity and mortality, for which effective treatments are lacking. In recent years, microRNAs (miRs) have been shown to regulate numerous biological processes can function as therapeutic options various diseases. However, the poor stability cell entry properties of miRs greatly limited their clinical application. this study, we developed tetrahedral framework nucleic acid (tFNA)-based bioswitchable miR delivery system (BiRDS) deliver miR-150 treatment sepsis. BiRDS showed anti-inflammatory effects both in vitro vivo by regulating NF-κB Notch1 pathways. Therefore, holds promise an ideal candidate tackling systemic inflammation multiorgan dysfunction septic patients future.

Language: Английский

Citations

2
Shadows and lights in sepsis immunotherapy DOI
Guillaume Monneret,

Muzhda Haem Rahimi,

Anne‐Claire Lukaszewicz

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(16), P. 2125 - 2133

Published: Oct. 17, 2024

Introduction Sepsis remains a major global public health challenge. The host's response in sepsis involves both an exaggerated inflammatory reaction and immunosuppressive mechanisms. A better understanding of this has shed light on the failure anti-inflammatory therapies administered under 'one size fits all' approach during last decades.

Language: Английский

Citations

0