Lipid Levels and Atherogenic Indices as Important Predictive Parameters in the Assessment of Cardiovascular Risk in Patients with Pulmonary Tuberculosis—Slovak Pilot Study

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 365 - 365

Published: Feb. 20, 2025

Background and Objective: Tuberculosis is one of the globally prevalent infectious diseases. Lipids play a crucial role in its development as well other diseases cardiovascular system. Cardiovascular significantly worsen functional vital prognosis tuberculosis patients. The aim study was to assess differences lipid profile, glucose, atherogenic markers between patients healthy individuals. Materials Methods: project involved 34 diagnosed with pulmonary (TB) control group (CG: n = 35). following were assessed: total cholesterol (CHOL), low-density lipoprotein (LDL), high-density (HDL), triglycerides (TG), glucose. Atherogenic indices: Castelli risk index I (CRI-I), II (CRI-II), plasma (AIP) coefficient (AC) calculated from profile parameters using appropriate formulas. Results: A statistically significant difference found CG TB CHOL, LDL HDL (p < 0.001). Based on indices CRI-I AIP, people can be classified into high group. By fitting ROC curve, shown effective predictors tuberculosis. Conclusions: are useful for detecting disease may help identify risks that might otherwise missed.

Language: Английский

Fixed-dose ruscus extract combination and its place in current clinical guidelines for the treatment of chronic venous diseases

Ambulatornaya khirurgiya = Ambulatory Surgery (Russia), Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Chronic venous diseases (CVD) is the most common lower extremity vascular pathology. Various vein-specific symptoms and syndromes associated with CVD negatively affect all components of quality life in modern society. The appearance development have been proven to be C-nociceptor irritation evoked by so-called algogens – biologically active substances occurred due inflammation endothelial dysfunction along local temperature elevation intravenous pressure. Endothelial mainly phlebostasis a decrease shear stress, leading hypoxia cells. Further, multi-stage mechanism leukocyte-endothelial interaction activated, which results microangiopathy at microcirculatory level, as well valve apparatus injury varicose transformation principal superficial veins macrocirculatory level. It evident that suppression inflammatory reaction not only leads reduction or relief symptoms, but also prevents macro- disorders. In this regard, phlebotropic, venoactive, pharmacological drugs targeting different pathogenetic mechanisms progression present great interest. case, despite group phleboprotective effect, specific for achieving it may significant differences various venoactive agents. review, we discuss main indications instructions use phlebotropic patients CVD, drawing on established international Russian clinical guidelines.

Language: Английский

Fixed-dose combinations in pharmacotherapy of chronic venous diseases

Ambulatornaya khirurgiya = Ambulatory Surgery (Russia), Journal Year: 2024, Volume and Issue: 21(2), P. 44 - 51

Published: Nov. 17, 2024

Chronic venous diseases are the most common vascular of lower extremities, negatively affecting all components quality life in modern society. Due to their high prevalence, prevention and treatment chronic one priorities national healthcare systems industrially developed countries. In recent years, numerous experimental clinical studies have uncovered an important role inflammation endothelial dysfunction pathogenesis diseases, which determine not only a wide range vein-specific symptoms, but also main drivers pathological remodelling vein wall its valve apparatus, followed by development varicose syndrome more severe insufficiency. Modern knowledge enables us identify several priority strategies aimed at managing basic pathophysiological mechanisms progression disease. Pharmacotherapy with phlebotropic drugs is them. Some these able inhibit inflammation, improve microcirculatory bed regulation, increase tone contractility and, as result, positive effect on signs This review presents mechanism action drug that new Russian Federation. It combination Ruscus aculeatus extract (Ruscus extract) hesperidin methyl chalcone (HMC) ascorbic acid. Studies showed level evidence efficacy safety this for patients various forms diseases. unique features action, optimal focus groups use may include different age early-stage disease, symptoms predominate, oedema.

Language: Английский