Highlights in Science Engineering and Technology,
Journal Year:
2024,
Volume and Issue:
123, P. 423 - 429
Published: Dec. 24, 2024
This
paper
reviews
recent
advances
and
challenges
in
epidermal
medical
engineering
scaffold
material
research.
The
basic
elements
of
tissue
include
seed
cells,
materials
bioactive
factors.
Current
skin
techniques
offer
innovative
therapeutic
avenues
for
the
repair
large
wounds,
mainly
through
suitable
scaffolds.
also
discusses
principles
regeneration,
including
structure
function,
process
explores
potential
stem
cells
exosomes
scar-free
healing.
Future
research
directions
will
focus
on
developing
high-performance
biomaterials
scaffolds,
optimising
cell
delivery
methods,
finding
optimal
sources
maintaining
activity.
In
particular,
combined
use
natural
polymers
such
as
filipin
proteins
sodium
alginate
is
expected
to
create
composites
that
more
closely
resemble
extracellular
matrices,
thus
better
promoting
proliferation
differentiation.
addition,
study
offers
new
ways
achieve
healing,
potentially
improving
healing
efficiency
reducing
scar
formation
when
with
bioscaffolds.
The
management
of
chronic
infected
wounds
remains
a
significant
clinical
challenge,
largely
due
to
the
deficiency
optimal
wound
dressings
with
adequate
mechanical
strength,
appropriate
adhesiveness,
and
efficient
sustainable
antibacterial,
reactive
oxygen
species
(ROS)
scavenging,
pro-angiogenesis,
immunomodulation
properties.
To
address
such
dilemma,
we
employed
simple
facile
strategy
utilize
resveratrol
(RSV)
as
functional
component
mediate
hydrogel
gelation
in
this
study.
structure
obtained
was
supported
by
multibond
network,
which
not
only
endowed
resultant
product
superior
strength
moderate
adhesiveness
but
also
effectively
prolonged
bioavailability
RSV.
This
successfully
integrated
entire
system
ROS
Subsequent
vivo
evidence
has
verified
that
material
capable
accelerate
healing
wounds.
underlying
mechanism
can
be
explained
is
propelling
macrophage
polarization
from
M1
M2
phenotype
through
modulating
PI3K/AKT
signaling
pathway
activate
nuclear
factor
erythroid
2-related
2
(Nrf2)
well
maintaining
mitochondrial
membrane
potential
level
normal
state
under
excessive
inflammatory
oxidative
stimulus.
In
summary,
multifunctional
dressing
provides
feasible
way
promote
RSV,
conducive
for
preparing
promising
candidate
healing.
What
more
important,
it
beneficial
reveal
correlative
mechanisms
establish
advanced
therapeutic
platform
targeting
other
complex
infection
microenvironment.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 375 - 375
Published: Feb. 5, 2025
Background:
Angiogenesis,
the
formation
of
new
blood
vessels
from
pre-existing
ones,
plays
a
pivotal
role
in
wound
healing,
particularly
surgical
contexts.
Methods
and
results:
However,
this
process
can
be
significantly
impaired
patients
with
childhood
obesity,
resulting
delayed
healing
additional
complications.
The
biological
is
complex,
involving
angiogenesis,
cell
proliferation,
inflammation,
tissue
remodeling.
This
review
aims
to
explore
recent
advancements
research
on
angiogenesis
wounds
focus
growth
factors,
microcirculation,
innovative
therapeutic
strategies.
Conclusions:
It
highlights
approaches
such
as
administration
factors
application
biomaterials
enhance
angiogenesis.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42551 - e42551
Published: Feb. 1, 2025
γ-Oryzanol
(Orz)
is
a
powerful
antioxidant
found
in
rice
bran
and
oil,
known
for
its
numerous
health
benefits.
Nevertheless,
precise
impact
on
skin
wound
healing
remains
largely
unexplored.
This
research
focuses
comprehensively
examining
the
ability
of
Orz
to
promote
tissue
repair
through
laboratory-based
animal
model
experiments.
The
further
examines
antimicrobial
activity
role
promoting
anti-inflammatory
effects.
To
evaluate
effect
repair,
scratch
assays
performed
vitro
were
used
analyze
cellular
migration.
An
vivo
experiment
utilizing
rat
excision
was
carried
out
investigate
contraction
rates
histological
modifications.
granulation
from
dead
space
examined
assess
levels
inflammatory
mediators,
free
radicals,
activity.
findings
study
demonstrated
improves
viability
while
facilitating
proliferation
migration
NIH-3T3
cells.
It
promotes
generation
growth
factors,
such
as
fibroblast
factor
21
transforming
factor-β.
Moreover,
exhibited
significant
against
various
pathogens
commonly
wounds.
ointment
with
10%
showed
effectiveness
healing,
indicated
by
notable
observed
14th
day
after
surgery.
Histological
analysis
that
application
resulted
remarkable
heightened
proliferation,
improved
formation
new
blood
vessels.
also
elevate
interleukin-10
levels,
reduce
tumor
necrosis
factor-α
ED-1-immunopositive
cells,
enhance
enzyme
activity,
thereby
mitigating
oxidative
damage
tissues
throughout
initial
stages
repair.
These
results
indicate
holds
promise
treatment
surface
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 242 - 242
Published: Feb. 12, 2025
Background/Objectives:
C24
ceramide
plays
a
crucial
role
in
skin
regeneration
and
wound
healing;
however,
its
hydrophobic
nature
limits
application
therapeutic
formulations.
This
study
aims
to
enhance
the
bioavailability
efficacy
of
by
developing
ceramide-based
lipid
nanoparticles
(C24-LNP)
evaluate
their
impact
on
healing.
Methods:
C24-LNP
was
synthesized
characterized
for
aqueous
stability
bioavailability.
In
vitro
experiments
were
conducted
assess
effects
keratinocyte
proliferation
migration.
Molecular
biological
analysis
examined
key
signaling
pathways,
including
AKT
ERK1/2
phosphorylation.
Additionally,
an
vivo
mouse
model
utilized
healing
efficacy,
with
histological
performed
epidermal
dermal
regeneration.
Results:
exhibited
improved
compared
free
ceramide.
studies
demonstrated
that
significantly
promoted
revealed
activation
which
are
critical
cell
growth
showed
accelerated
closure
control
group.
Histological
confirmed
enhanced
regeneration,
leading
structural
functional
repair.
Conclusion:
The
nanoparticle
formulation
effectively
increases
enhances
presents
scalable
cost-effective
alternative
traditional
factor-based
therapies,
offering
significant
potential
clinical
applications
care
dermatological
treatments.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1769 - 1769
Published: Feb. 19, 2025
PDRN,
polydeoxyribonucleotide,
which
is
used
as
a
tissue-regeneration
material,
present
in
human
cells
under
physiological
conditions
and
stimulates
regeneration
metabolic
activity.
PDRN
can
be
biomaterial
for
several
types
of
regeneration,
including
wound
healing,
to
promote
cell
growth
growth-factor
production.
The
aims
this
study
were
determine
the
effect
derived
from
placenta-derived
mesenchymal
stem
(hPD-MSCs)
on
cellular
through
A2A
receptor
signaling
investigate
its
therapeutic
effects
mouse
model
healing.
Human
(UNIPlax)
was
extracted
hPD-MSCs
fragmented
via
sonication
system
evaluated
migration
HaCaT
an
vitro
wound-healing
vivo.
Compared
with
sham
treatment,
UNIPlax
treatment
significantly
increased
injured
(p
<
0.05).
Additionally,
tube
formation
umbilical
vein
endothelial
(HUVECs)
greater
than
that
group
0.05),
mediated
receptor.
Furthermore,
led
decrease
size;
addition,
area
granulation
rate
collagen
at
site
those
0.001).
We
also
confirmed
promoted
tissue
expression
VEGF
Taken
together,
these
findings
indicate
has
potential
damaged
tissues,
during
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 544 - 544
Published: Feb. 21, 2025
Background:
Chronic
wounds,
such
as
diabetic
ulcers,
often
fail
to
progress
through
healing
due
persistent
inflammation,
infections,
and
extracellular
matrix
(ECM)
imbalances.
Cathepsin
D,
an
aspartate
protease
active
in
acidic
environments,
plays
a
pivotal
role
wound
by
mediating
inflammatory
responses,
ECM
remodeling,
macrophage
phenotype
transitions.
Its
dysregulation,
however,
can
impair
healing,
highlighting
the
need
for
targeted
modulation
of
its
activity.
The
aim
this
study
was
investigate
molecular
interaction
between
Fe2+
cathepsin
D’s
catalytic
core
ionic
zipper
under
physiological
conditions
identify
strategies
enhance
tissue
repair
accelerate
chronic
wounds.
Methods:
structure
D
obtained
from
Protein
Data
Bank
(PDB)
analyzed
using
UCSF
Chimera.
Molecular
interactions
ferrous
ions
(Fe2+)
were
studied,
focusing
on
key
residues
(D33
D231)
(E5,
E180,
D187).
Results:
Our
results
showed
that
form
96
kDa
dimer,
consisted
heterodimers
with
distinct
amino
acid
chains,
where
D33
D231
formed
site,
E5,
D187
constituted
zipper.
A
functional
pocket
containing
conserved
D231,
essential
proteolytic
activity,
identified.
At
pH
(~7.5),
exhibited
most
potent
Fe2+,
energies
−7
×
1017
J
at
oxygen
atoms
carboxylate
group
(OD1)
α-carbon
(CA)
atoms,
whereas
slightly
lower
−6
γ-carbon
atom
(CG)
CA
atoms.
(~4),
E5
primary
interacting
residue,
shortest
distance
(2.69
Å),
stable
across
several
emphasizing
metal
binding.
Conclusions:
strongly
influence
Fe2.
pH,
demonstrate
robust
energetically
efficient
binding
Fe2+.
same
time,
conditions,
emerges
residue
involved,
potentially
affecting
D.
These
insights
provide
foundation
targeting
specific
modulate
presenting
promising
opportunities
therapeutic
aimed
improving
healing.
