Clinical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Small nucleolar ribonucleic acids (snoRNAs) have emerged as crucial regulators in various biological processes and garnered significant attention for their potential roles cancer. These noncoding (RNAs) primarily guide ribosomal RNA (rRNA) pseudouridylation 2'-O-methylation modifications exhibit stable expression the serum, making them promising biomarkers therapeutic targets. Digestive tract cancer poses a severe global health threat due to its high mortality rate difficulty early detection. Understanding molecular mechanisms underlying tumor development is critical improving diagnostic strategies. RNAs, with diverse functions presence fluids, offer unique opportunity address these challenges. RNAs are class of small mainly located nucleolus eukaryotic cells. They play essential maturation modification rRNAs, transfer nuclear RNAs. also participate alternative splicing regulation microRNA-like functions, influencing cellular processes. Abnormal snoRNAs has been closely linked development, invasion, metastasis digestive system tumors. Given serum ability function independently host genes, hold great screening, prognosis prediction, targets Their involvement key signaling pathways provides foundation developing targeted therapies patient outcomes. This review highlights significance tumors, roles, connections progression, clinical applications. Further exploration expected provide new insights into diagnosis treatment

Language: Английский