Intestinal microecology dysbiosis in inflammatory bowel disease: Pathogenesis and therapeutic strategies DOI
Yue Yin,

Weibo Feng,

Xilang Chen

et al.

The Innovation Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100092 - 100092

Published: Jan. 1, 2024

<p>Inflammatory bowel disease (IBD) is an autoimmune characterized by non-infectious, chronic, and recurrent inflammation in the intestine, with unclear pathogenesis increasing incidence. Currently, immunosuppressive drugs are commonly used clinical treatment of IBD to alleviate intestinal inflammation, but their effectiveness not ideal. Therefore, it crucial investigate develop new therapeutic strategies. As a significant component barrier, microbiota closely related metabolism, barrier protection, immune regulation. With advances research technology, pivotal role microecology dysbiosis progression has gained attention recent years. Microbial therapies, including microecological modulators, fecal transplantation, phage therapy have also become hotspots treatment, showing promising applications. However, complex relationship between remains unclear, trials investigating microbial therapies face limitations. To inspire further research, this review thoroughly summarizes physiological structure function microecology, as well characteristics patients. We analyze status for application organoid models preclinical studies.</p>

Language: Английский

The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease DOI Creative Commons
Samantha L. Dawson, Emma Todd, Alister C. Ward

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 329 - 329

Published: Jan. 31, 2025

Nutrition, the gut microbiota and immunity are all important factors in maintenance of health. However, there is a growing realization complex interplay between these elements coalescing nutrition-gut microbiota-immunity axis. This regulatory axis critical for health with disruption being implicated broad range diseases, including autoimmune disorders, allergies mental disorders. new perspective continues to underpin number innovative therapeutic strategies targeting different this treat relevant diseases. review describes inter-relationships nutrition, immunity. It then details several human diseases where has been identified presents examples how various may be targeted therapeutically as alternate treatment

Language: Английский

Citations

2
Human Microbiome and Bacteriophages: Impacts on Health and Disease DOI
Muhammad Sheraz, Hongyan Shi, Santasree Banerjee

et al.

Current Clinical Microbiology Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 18, 2025

Language: Английский

Citations

0
The role of bacteriophage in inflammatory bowel disease and its therapeutic potential DOI
Yang Xiao, Xinyu Yue, Xupeng Zhang

et al.

Critical Reviews in Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 12, 2025

Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory disorders impacting the gastrointestinal (GI) tract. It represents significant public health challenge due its rising global incidence and substantial impact on patients' quality life. Emerging research suggests pivotal role human microbiome in IBD pathogenesis. Bacteriophages, integral components microbiome, are indicated influence onset, progression, therapeutic strategies. Here, we review effect bacteriophages pathogenesis and, more specifically, gut bacteria, systemic immunity, susceptibility genes. Additionally, explore potential use modify microbiota improve outcomes patients. This highlights regulating modulating immune response Future studies personalized bacteriophage therapy integration into clinical practice could advance treatment strategies for IBD.

Language: Английский

Citations

0
Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and healthcare DOI Creative Commons
Huan Zhang,

B. J. Yang Lee,

Tong Wang

et al.

hLife, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Case report: Local bacteriophage therapy for fracture-related infection with polymicrobial multi-resistant bacteria: hydrogel application and postoperative phage analysis through metagenomic sequencing DOI Creative Commons
Volker Alt, André Gessner,

Maya Merabishvili

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 12, 2024

Fracture-related infections can be challenging, particularly with concomitant severe bone defects and multi-resistant microorganisms. We present a case of 42-year-old patient fracture-related infection following war injury from gunshot, resulting in 12-cm subtrochanteric segmental defect the detection four different Gram-negative bacteria. Due to antibiotic drug resistance, treatment bacteriophages was considered. Phage susceptibility testing revealed activity commercially available bacteriophage cocktail (Intesti bacteriophage, Eliava Institute, Tbilisi, Georgia). This phage included modified two-stage Masquelet technique. During first intervention, debrided samples for microbiological were harvested. The indwelling intramedullary rod removed, filled PMMA spacer loaded colistin stabilized plate. second procedure, removed silver-coated angular stable plate implanted. fibular autograft allograft cancellous chips. At end Intesti injected into DAC hydrogel this composite then put onto Postoperatively wound fluid collected over 72 h, high-throughput metagenomic sequencing performed. showed time-dependent release fluid, relatively high concentration after 12 decreasing DNA copies 0 h. Furthermore, we have assessed phages gel effect on vitro . results rapid (~1×10 3 PFU/mL). clinical course no relapse good consolidation 1 year without need any surgical revision. To best our knowledge, is that shows by metagenomics complex infection. Successful encourages further investigation therapy patients joint infections.

Language: Английский

Citations

1
Intestinal microecology dysbiosis in inflammatory bowel disease: Pathogenesis and therapeutic strategies DOI
Yue Yin,

Weibo Feng,

Xilang Chen

et al.

The Innovation Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100092 - 100092

Published: Jan. 1, 2024

<p>Inflammatory bowel disease (IBD) is an autoimmune characterized by non-infectious, chronic, and recurrent inflammation in the intestine, with unclear pathogenesis increasing incidence. Currently, immunosuppressive drugs are commonly used clinical treatment of IBD to alleviate intestinal inflammation, but their effectiveness not ideal. Therefore, it crucial investigate develop new therapeutic strategies. As a significant component barrier, microbiota closely related metabolism, barrier protection, immune regulation. With advances research technology, pivotal role microecology dysbiosis progression has gained attention recent years. Microbial therapies, including microecological modulators, fecal transplantation, phage therapy have also become hotspots treatment, showing promising applications. However, complex relationship between remains unclear, trials investigating microbial therapies face limitations. To inspire further research, this review thoroughly summarizes physiological structure function microecology, as well characteristics patients. We analyze status for application organoid models preclinical studies.</p>

Language: Английский

Citations

1