The B30.2/SPRY-Domain: A Versatile Binding Scaffold in Supramolecular Assemblies of Eukaryotes DOI Creative Commons
Peer R. E. Mittl, Hans‐Dietmar Beer

Crystals, Journal Year: 2025, Volume and Issue: 15(3), P. 281 - 281

Published: March 19, 2025

B30.2 domains, sometimes referred to as PRY/SPRY were originally identified by sequence profiling methods at the gene level. The domain comprises a concanavalin A-like fold consisting of two twisted seven-stranded anti-parallel β-sheets. domains are present in about 150 human and 700 eukaryotic proteins, usually fused other domains. represents scaffold, which, through six variable loops, binds different unrelated peptides or endogenous low-molecular-weight compounds. At cellular level, proteins engage supramolecular assemblies with important signaling functions. In humans, often found E3-ligases, such tripartite motif (Trim) SPRY domain-containing SOCS box Ran binding protein 9 −10, Ret-finger protein-like, Ring-finger proteins. recognizes target recruits E2-conjugase means involving specific adaptor Further well-studied methyltransferase Ash2L, some butyrophilins, Ryanodine Receptors. Although affinity an isolated its ligand might be weak, it can increase strongly due avidity effects upon recognition oligomeric targets context macromolecular machines.

Language: Английский

The B30.2/SPRY-Domain: A Versatile Binding Scaffold in Supramolecular Assemblies of Eukaryotes DOI Creative Commons
Peer R. E. Mittl, Hans‐Dietmar Beer

Crystals, Journal Year: 2025, Volume and Issue: 15(3), P. 281 - 281

Published: March 19, 2025

B30.2 domains, sometimes referred to as PRY/SPRY were originally identified by sequence profiling methods at the gene level. The domain comprises a concanavalin A-like fold consisting of two twisted seven-stranded anti-parallel β-sheets. domains are present in about 150 human and 700 eukaryotic proteins, usually fused other domains. represents scaffold, which, through six variable loops, binds different unrelated peptides or endogenous low-molecular-weight compounds. At cellular level, proteins engage supramolecular assemblies with important signaling functions. In humans, often found E3-ligases, such tripartite motif (Trim) SPRY domain-containing SOCS box Ran binding protein 9 −10, Ret-finger protein-like, Ring-finger proteins. recognizes target recruits E2-conjugase means involving specific adaptor Further well-studied methyltransferase Ash2L, some butyrophilins, Ryanodine Receptors. Although affinity an isolated its ligand might be weak, it can increase strongly due avidity effects upon recognition oligomeric targets context macromolecular machines.

Language: Английский

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