Unlocking the Code: The Role of Molecular and Genetic Profiling in Revolutionizing Glioblastoma Treatment DOI Creative Commons
Moustafa Mansour,

Ahmed M Kamer-Eldawla,

Reem W Malaeb

et al.

Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 43, P. 100881 - 100881

Published: Jan. 1, 2024

Glioblastoma (GBM) is the most aggressive primary brain cancer, characterized by profound molecular and cellular heterogeneity, which contributes to its resistance conventional therapies poor prognosis. Despite multimodal treatments including surgical resection, radiation, chemotherapy, median survival remains approximately 15 months. Recent advances in genetic profiling have elucidated key alterations subtypes of GBM, such as EGFR amplification, PTEN ATRX loss, TP53 alterations, significant prognostic therapeutic implications. These discoveries spurred development targeted aimed at disrupting aberrant signaling pathways like RTK/RAS/PI3K TP53. However, treatment a formidable challenge, driven tumor complex microenvironment (TME), intrinsic adaptive mechanisms. Emerging approaches aim address these challenges, use immunotherapies immune checkpoint inhibitors CAR T-cell therapies, target specific antigens but face hurdles due immunosuppressive TME. Additionally, novel strategies biopolymer-based interstitial focused ultrasound for blood-brain barrier disruption, nanoparticle-based drug delivery systems show promise enhancing efficacy precision GBM treatments. This review explores evolving landscape therapy, emphasizing importance personalized medicine through profiling, potential combination need innovative overcome resistance. Continued research into GBM's biology modalities offers hope improving patient outcomes.

Language: Английский

Fecal microbiota transplantation for the treatment of intestinal and extra‐intestinal diseases: Mechanism basis, clinical application, and potential prospect DOI Creative Commons

Dongxin Yi,

Tao Li,

Yuji Xiao

et al.

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

To review the theoretical basis and therapeutic effects of fecal microbiota transplantation (FMT) in various diseases animal experiments clinical studies, as well limitations current standards FMT application. PubMed Web Science databases were searched for articles published only English between 1975 2023 on reliable results treatment FMT. The properties gut its interactions with host metabolism are critical to human health, microbiome disturbance is closely associated intestinal extra-intestinal diseases. Therefore, tools targeting modulation have attracted increasing attention, among which represents most widely studied intervention strategy. This gathered summarized application diseases, metabolic hypertension, cancer, nervous system arthritis, elaborated beneficial that can be achieved by altering mechanisms action. In addition, potential risks side approach discussed, efforts standardize development Through a systemic outcome mechanism we aimed provide construction an optimized framework, so better exert prospects.

Language: Английский

Citations

0
Fungal influence on immune cells and inflammatory responses in the tumor microenvironment (Review) DOI Open Access
Jinke Zhang, Yahui Feng, Dongmei Li

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 11, 2024

In recent years, a growing body of research has highlighted the significant influence microbiota on tumor immunity within microenvironment (TME). While much attention been given to bacteria, emerging evidence suggests that fungi also play crucial roles in development. The present review aimed consolidate latest findings mechanisms governing interactions between and immune system or TME. By elucidating these intricate mechanisms, novel insights into modulation therapeutic strategies may be uncovered. Ultimately, deeper understanding interplay TME holds promise for development innovative management targeted drugs enhance therapy efficacy.

Language: Английский

Citations

0
Unlocking the Code: The Role of Molecular and Genetic Profiling in Revolutionizing Glioblastoma Treatment DOI Creative Commons
Moustafa Mansour,

Ahmed M Kamer-Eldawla,

Reem W Malaeb

et al.

Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 43, P. 100881 - 100881

Published: Jan. 1, 2024

Glioblastoma (GBM) is the most aggressive primary brain cancer, characterized by profound molecular and cellular heterogeneity, which contributes to its resistance conventional therapies poor prognosis. Despite multimodal treatments including surgical resection, radiation, chemotherapy, median survival remains approximately 15 months. Recent advances in genetic profiling have elucidated key alterations subtypes of GBM, such as EGFR amplification, PTEN ATRX loss, TP53 alterations, significant prognostic therapeutic implications. These discoveries spurred development targeted aimed at disrupting aberrant signaling pathways like RTK/RAS/PI3K TP53. However, treatment a formidable challenge, driven tumor complex microenvironment (TME), intrinsic adaptive mechanisms. Emerging approaches aim address these challenges, use immunotherapies immune checkpoint inhibitors CAR T-cell therapies, target specific antigens but face hurdles due immunosuppressive TME. Additionally, novel strategies biopolymer-based interstitial focused ultrasound for blood-brain barrier disruption, nanoparticle-based drug delivery systems show promise enhancing efficacy precision GBM treatments. This review explores evolving landscape therapy, emphasizing importance personalized medicine through profiling, potential combination need innovative overcome resistance. Continued research into GBM's biology modalities offers hope improving patient outcomes.

Language: Английский

Citations

0