Lactoferrin: Properties and Potential Uses in the Food Industry
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1404 - 1404
Published: Feb. 7, 2025
Lactoferrin
(LF)
is
an
80
kDa
glycoprotein
that
contains
approximately
700
amino
acids
and
a
member
of
the
transferrin
family.
The
essential
properties
LF,
including
antimicrobial,
antiviral,
anticancer,
anti-inflammatory,
antioxidant,
probiotic
effects,
have
been
studied
for
decades.
iron
chelation
activity
LF
significantly
associated
with
its
antioxidant
properties.
Owing
to
prebiotic
activity,
also
facilitates
growth
beneficial
microorganisms
iron-defense
immediate-effect
on
pathogens.
Additionally,
ability
regulate
cell
signaling
pathways
immune
responses
makes
prominent
modulatory
protein.
These
diverse
characteristics
gained
interest
in
therapeutic
potential.
Studies
suggested
could
serve
as
alternative
source
antibiotics
severe
infections
illnesses.
has
food
industry
potential
additive
fortify
products
such
yogurt,
infant
formula,
meat
derivatives
while
improving
shelf
life
foods
providing
antimicrobial
activity.
Prior
using
industry,
safety
toxicity
processing
are
necessary
be
investigated.
investigations
crucial
addressing
harm
or
side
effects
ensuring
healthy
lifestyle.
This
review
discusses
attributes
particularly
exploitation
industry.
Language: Английский
Lactoferrin—A Regulator of Iron Homeostasis and Its Implications in Cancer
Molecules,
Journal Year:
2025,
Volume and Issue:
30(7), P. 1507 - 1507
Published: March 28, 2025
Cancer
is
a
global
health
challenge,
and
its
development
closely
linked
to
iron
metabolism.
cells
have
an
increased
demand
for
this
element,
which
promotes
their
proliferation,
invasion,
metastasis.
Excess
catalyzes
the
formation
of
reactive
oxygen
species
(ROS),
can
both
induce
ferroptosis
initiate
oncogenic
signaling
pathways.
The
deregulation
metabolism
in
cancer
patients
leads
anemia
or
toxic
overload
also
affects
gut
microbiota.
Lactoferrin
(LF),
glycoprotein
with
strong
chelating
properties,
regulate
availability
cells,
thereby
limiting
growth
progression.
By
free
Fe
ions,
LF
reduces
oxidative
stress
inhibits
mechanisms
that
promote
carcinogenesis.
Additionally,
it
exhibits
immunomodulatory
anti-inflammatory
effects
may
enhance
body’s
anti-tumor
response.
This
review
analyses
action
lactoferrin
context
cancer,
particular
focus
on
chelating,
antioxidant,
properties.
multidirectional
make
promising
component
preventive
therapeutic
strategies,
requiring
further
clinical
studies.
Language: Английский
Controversial role of lactoferrin in cancer: A narrative review
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
181, P. 117743 - 117743
Published: Dec. 1, 2024
Lactoferrin
(Lf)
is
a
positively
charged
iron-binding
glycoprotein
that
has
piqued
the
scientific
community's
interest
due
to
its
pleiotropic
behavior,
exhibiting
wide
range
of
biological
activities,
including
antimicrobial,
antioxidant,
anti-inflammatory,
immunomodulatory,
and
anticancer
effects.
This
narrative
review
explores
current
understanding
Lf's
role
in
cancer,
focusing
on
endogenously
expressed
human
full-length
ΔLf
isoforms,
effects
treatment
with
exogenous
bovine
Lf.
We
evaluated
compared
mechanisms
by
which
Lf
influences
tumorigenesis
cancer
progression,
impact
key
processes
such
as
cell
growth,
apoptosis,
angiogenesis,
migration,
invasiveness.
Notably,
action
show
some
divergences,
presumably
slight
structural
differences
may
lead
opposing
Insights
from
this
comparison
help
identify
new
variants
enhanced
activity.
Indeed,
both
showed
substantial
activity,
prompting
researchers
investigate
their
potential
utility
prevention
progression.
However,
studies
have
indicated
high
levels
expression
be
linked
increased
carcinogenesis
metastasis,
reflecting
intricate
context-dependent
cancer.
Thus,
we
emphasize
need
for
deeper
comprehension
biology
regulation
enhance
more
targeted
therapeutic
strategies,
encouraging
further
research
area.
Language: Английский
Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 118 - 118
Published: Dec. 30, 2024
Human
milk
oligosaccharides
(HMOs),
the
third
most
abundant
solid
component
in
human
milk,
vary
significantly
among
women
due
to
factors
such
as
secretor
status,
race,
geography,
season,
maternal
nutrition
and
weight,
gestational
age,
delivery
method.
In
recent
studies,
HMOs
have
been
shown
a
variety
of
functional
roles
development
infants.
Because
are
not
digested
by
infants,
they
act
metabolic
substrates
for
certain
bacteria,
helping
establish
infant’s
gut
microbiota.
By
encouraging
growth
advantageous
intestinal
these
sugars
function
prebiotics
produce
short-chain
fatty
acids
(SCFAs),
which
essential
health.
can
also
specifically
reduce
harmful
microbes
viruses
binding
epithelium,
preventing
illness.
HMO
addition
infant
formula
is
safe
promotes
healthy
development,
infection
prevention,
Current
formulas
frequently
contain
(OSs)
that
differ
structurally
from
those
found
making
it
unlikely
would
reproduce
unique
effects
HMOs.
However,
there
growing
trend
producing
OSs
resembling
HMOs,
but
limited
data
make
unclear
whether
offer
additional
therapeutic
benefits
compared
non-human
OSs.
Better
knowledge
how
mammary
gland
synthesizes
could
direct
technologies
yield
broad
complex
with
OS
compositions
closely
mimic
milk.
This
review
explores
HMOs’
nature
vital
role
health,
examining
variation
composition
its
contributing
factors.
It
highlights
technological
advances
enabling
large-scale
studies
on
Furthermore,
multifunctional
biological
processes
brain
microbiota
immune
response
regulation
investigated.
The
structural
distinctions
between
other
mammalian
discussed,
focus
toward
more
precise
replicas
Language: Английский
Bovine Colostrum in Pediatric Nutrition and Health
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4305 - 4305
Published: Dec. 13, 2024
Bovine
colostrum
(BC),
the
first
milk
secreted
by
mammals
after
birth,
is
a
trending
alternative
source
for
supplementing
infants
and
children,
offering
benefits
gut
immune
health.
Its
rich
components,
such
as
proteins,
immunoglobulins,
lactoferrin,
glycans,
are
used
to
fortify
diets
support
development.
Preterm
development
crucial,
especially
in
maturation
of
essential
systems,
from
2010
2020,
approximately
15%
all
premature
births
occurred
at
less
than
32
weeks
gestation
worldwide.
This
review
explores
composition,
benefits,
effects
BC
on
general
along
with
preterm
who
require
special
care,
highlights
its
role
growth
also
associated
specific
pediatric
diseases,
including
necrotizing
enterocolitis
(NEC),
infectious
diarrhea,
inflammatory
bowel
disease
(IBD),
short-bowel
syndrome
(SBS),
neonatal
sepsis,
gastrointestinal
respiratory
infections,
some
minor
conditions.
discusses
clinical
trials
regarding
these
conditions
which
occasionally
encountered
infants.
The
anti-inflammatory,
antimicrobial,
immunomodulatory,
antiviral
properties
discussed,
emphasizing
mechanisms
action.
Clinical
trials,
particularly
humans,
provide
evidence
supporting
inclusion
formulas
diets,
although
precise
standards
age,
feeding
time,
amounts
needed
ensure
safety
efficacy.
However,
potential
adverse
effects,
allergic
reactions
caseins
immunoglobulin
E,
must
be
considered.
More
comprehensive
necessary
expand
infant
feeding,
important
components
BC,
should
further
studied
their
synergistic
diseases.
Ultimately,
shows
promise
health
incorporated
into
nutritional
supplements
caution.
Language: Английский
Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(24), P. 2018 - 2018
Published: Dec. 16, 2024
Nanoparticles
(NPs)
have
emerged
as
a
potent
choice
for
various
applications,
from
drug
delivery
to
agricultural
studies,
serving
an
alternative
and
promising
methodology
future
advancements.
They
been
widely
explored
in
systems,
demonstrating
immense
promise
high
efficiency
the
of
numerous
biomolecules
such
proteins
anticancer
agents,
either
solely
or
modified
with
other
compounds
enhance
their
capabilities.
In
addition,
utilization
NPs
extends
antimicrobial
where
they
are
used
develop
novel
antibacterial,
antifungal,
antiviral
formulations
advanced
characteristics.
Lactoferrin
(Lf)
is
glycoprotein
recognized
its
significant
multifunctional
properties,
antimicrobial,
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects.
Its
activity
has
broad
distribution
human
body,
Lf
receptors
present
multiple
regions.
Current
research
shows
that
utilized
NP
technology
surface
material,
encapsulated
biomolecule,
even
itself.
Due
abundance
regions,
can
be
employed
material
targeted
strategies,
particularly
crossing
BBB
targeting
specific
cancers.
Furthermore,
synthesized
structure,
positioning
it
strong
candidate
NP-related
applications.
this
article,
we
explore
highlighted
underexplored
areas
applications
research.
Language: Английский