Tapping into Metabolomics for Understanding Host and Rotavirus Group A Interactome DOI Creative Commons
Phiona Moloi Mametja,

Mmei Cheryl Motshudi,

Clarissa Marcelle Naidoo

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 765 - 765

Published: May 10, 2025

Group A rotavirus continues to be a leading global etiological agent of severe gastroenteritis in young children under 5 years age. The replication this virus the host is associated with occurrence Lewis antigens and secretor condition. Moreover, histo-blood group (HBGAs) act as attachment factors outer viral protein VP4 for rotavirus. Therefore, study, we employed metabolomic approach reveal potential signature metabolic molecules pathways specific P[8] strain infection (VP4 genotype), which expression HBGA combined (Le) phenotypes, specifically secretor/Le(a+b+). Further integration achieved metabolomics results lipidomic proteomics metadata analyses was performed. Saliva samples were collected from diagnosed negative or positive total 22 that downregulated include butyrate, putrescine, lactic acid, 7 analytes. upregulated molecule 2,3-Butanediol. Significant pathway alterations also observed various metabolism processes, including galactose butanoate metabolisms. Butyrate played significant role revealed exhibit different reactions glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, fatty acyls. butyrate might interact receptors free acid receptor 2 (FFAR2) 3 (FFAR3). provide fundamental insight into status monitoring its effects on humans.

Language: Английский

Tapping into Metabolomics for Understanding Host and Rotavirus Group A Interactome DOI Creative Commons
Phiona Moloi Mametja,

Mmei Cheryl Motshudi,

Clarissa Marcelle Naidoo

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 765 - 765

Published: May 10, 2025

Group A rotavirus continues to be a leading global etiological agent of severe gastroenteritis in young children under 5 years age. The replication this virus the host is associated with occurrence Lewis antigens and secretor condition. Moreover, histo-blood group (HBGAs) act as attachment factors outer viral protein VP4 for rotavirus. Therefore, study, we employed metabolomic approach reveal potential signature metabolic molecules pathways specific P[8] strain infection (VP4 genotype), which expression HBGA combined (Le) phenotypes, specifically secretor/Le(a+b+). Further integration achieved metabolomics results lipidomic proteomics metadata analyses was performed. Saliva samples were collected from diagnosed negative or positive total 22 that downregulated include butyrate, putrescine, lactic acid, 7 analytes. upregulated molecule 2,3-Butanediol. Significant pathway alterations also observed various metabolism processes, including galactose butanoate metabolisms. Butyrate played significant role revealed exhibit different reactions glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, fatty acyls. butyrate might interact receptors free acid receptor 2 (FFAR2) 3 (FFAR3). provide fundamental insight into status monitoring its effects on humans.

Language: Английский

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