Single-cell genomics and spatial transcriptomics in islet transplantation for diabetes treatment: advancing towards personalized therapies DOI Creative Commons
Lisha Mou,

Tony Bowei Wang,

Yuxian Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

Diabetes mellitus (DM) is a global health crisis affecting millions, with islet transplantation emerging as promising treatment strategy to restore insulin production. This review synthesizes the current research on single-cell and spatial transcriptomics in context of transplantation, highlighting their potential revolutionize DM management. Single-cell RNA sequencing, offers detailed look into diversity functionality within grafts, identifying specific cell types states that influence graft acceptance function. Spatial complements this by mapping gene expression tissue's context, crucial for understanding microenvironment surrounding transplanted islets interactions host tissues. The integration these technologies comprehensive view cellular microenvironments, elucidating mechanisms underlying function, survival, rejection. instrumental developing targeted therapies enhance performance patient outcomes. emphasizes significance avenues informing clinical practices improving outcomes patients through more effective strategies. Future directions include application personalized medicine, developmental biology, regenerative predict disease progression responses. Addressing ethical technical challenges will be successful implementation integrated approaches practice, ultimately enhancing our ability manage improve quality life.

Language: Английский

Single-cell genomics and spatial transcriptomics in islet transplantation for diabetes treatment: advancing towards personalized therapies DOI Creative Commons
Lisha Mou,

Tony Bowei Wang,

Yuxian Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

Diabetes mellitus (DM) is a global health crisis affecting millions, with islet transplantation emerging as promising treatment strategy to restore insulin production. This review synthesizes the current research on single-cell and spatial transcriptomics in context of transplantation, highlighting their potential revolutionize DM management. Single-cell RNA sequencing, offers detailed look into diversity functionality within grafts, identifying specific cell types states that influence graft acceptance function. Spatial complements this by mapping gene expression tissue's context, crucial for understanding microenvironment surrounding transplanted islets interactions host tissues. The integration these technologies comprehensive view cellular microenvironments, elucidating mechanisms underlying function, survival, rejection. instrumental developing targeted therapies enhance performance patient outcomes. emphasizes significance avenues informing clinical practices improving outcomes patients through more effective strategies. Future directions include application personalized medicine, developmental biology, regenerative predict disease progression responses. Addressing ethical technical challenges will be successful implementation integrated approaches practice, ultimately enhancing our ability manage improve quality life.

Language: Английский

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