Nanoscale Extracellular Vesicle-Enabled Liquid Biopsy: Advances and Challenges for Lung Cancer Detection DOI Creative Commons
Adeel Khan, Faisal Raza, Nongyue He

et al.

Micromachines, Journal Year: 2024, Volume and Issue: 15(10), P. 1181 - 1181

Published: Sept. 24, 2024

Lung cancer is responsible for the death of over a million people worldwide every year. With its high mortality rate and exponentially growing number new cases, lung major threat to public health. The poor survival rates patients can be attributed stealth progression late diagnosis. For long time, intrusive tissue biopsy has been considered gold standard diagnosis subtyping; however, intrinsic limitations cannot overlooked. In addition being invasive costly, it also suffers from in sensitivity specificity, not suitable repeated sampling, provides restricted information about tumor molecular landscape, inaccessible several cases. To cope with this, advancements diagnostic technologies, such as liquid biopsy, have shown great prospects. Liquid an innovative non-invasive approach which cancer-related components called biomarkers are detected body fluids, blood, urine, saliva others. It offers less alternative potential applications routine screening, predicting treatment outcomes, evaluating effectiveness, detecting residual disease, or disease recurrence. A large research articles indicated extracellular vesicles (EVs) ideal biopsy. EVs heterogeneous collection membranous nanoparticles diverse sizes, contents, surface markers. play critical role pathophysiological states gained prominence prognostic multiple diseases, including cancer. this review, we provide detailed overview EV-based Moreover, highlights strengths weaknesses various contemporary techniques EV isolation analysis challenges that need addressed ensure widespread clinical application biopsies summary, present interesting opportunities development novel platforms cancer, one most abundant cancers millions deaths worldwide.

Language: Английский

Insights into tumor-derived exosome inhibition in cancer therapy DOI
Ziwei Tang, Cheng Chen, Chen Zhou

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 285, P. 117278 - 117278

Published: Jan. 13, 2025

Language: Английский

Citations

1
Advancements in the conservation of the conformational epitope of membrane protein immunogens DOI Creative Commons

Aisha Mahboob,

Nishat Fatma,

Faraz Ahmed

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Generating antibodies targeting native membrane proteins presents various challenges because these are often embedded in the lipid bilayer, possess extracellular and intracellular domains, undergo post-translational modifications. These properties of MPs make it challenging to preserve their stable conformations for immunization or antibody generation outside membranes. In addition, hydrophobic due membrane-spanning regions, making them difficult solubilize purify form. Therefore, employing purified immunogen preparation may result denaturation loss structure, rendering inadequate producing recognizing conformations. Despite obstacles, new approaches have emerged address problems. We outline recent advancements designing preparing immunogens produce MPs. Strategies outlined here relevant research, diagnostics, therapies vaccination purposes.

Language: Английский

Citations

0
Exosome-based therapeutics: Advancing drug delivery for neurodegenerative diseases DOI

Srijana Rai,

Suman Kumar Ray, Jagat R. Kanwar

et al.

Molecular and Cellular Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 104004 - 104004

Published: March 1, 2025

Language: Английский

Citations

0
Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application DOI Creative Commons
E. Caroline Wylie,

R. M. Rowan,

Dessislava Malinova

et al.

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Multiple myeloma (MM), characterised by the clonal proliferation of plasma cells in bone marrow, is second most common haematological malignancy worldwide. Although there now an impressive artillery therapeutics to tackle this condition, resistance remains a prevalent issue. The marrow microenvironment performs crucial role supporting MM pathogenesis and promoting development therapeutic resistance. Extracellular vesicles (EVs), small that carry bioactive molecules, are key component cell‐to‐cell communication within microenvironment. In review, we summarise contribution EVs disease progression anticancer treatment discuss potential applications MM.

Language: Английский

Citations

0
Roles and Therapeutic Targeting of Exosomes in Sepsis‐Induced Cardiomyopathy DOI Creative Commons
Rui Fan, Han Liu,

Qun Liang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(8)

Published: April 1, 2025

ABSTRACT Sepsis‐induced cardiomyopathy (SICM) is a complex and fatal manifestation of sepsis, characterised by myocardial dysfunction that exacerbates the clinical prognosis in septic patients. While pathophysiology SICM remains incompletely understood, emerging evidence highlights multifaceted functions exosomes, small membrane‐bound extracellular vesicles, mediating inflammatory responses cardiac involved this condition. During exosomes are secreted various cells, such as cardiomyocytes, endothelial cells macrophages, which serve critical messengers, transferring proteins, lipids RNA molecules influence recipient thus affecting cellular disease progression. This review summarises basics focuses on exosome‐mediated mechanisms SICM, including their role inflammation, oxidative stress, mitochondrial injury, offering novel insights into exosome‐based therapeutic strategies SICM.

Language: Английский

Citations

0
Nanoscale Extracellular Vesicle-Enabled Liquid Biopsy: Advances and Challenges for Lung Cancer Detection DOI Creative Commons
Adeel Khan, Faisal Raza, Nongyue He

et al.

Micromachines, Journal Year: 2024, Volume and Issue: 15(10), P. 1181 - 1181

Published: Sept. 24, 2024

Lung cancer is responsible for the death of over a million people worldwide every year. With its high mortality rate and exponentially growing number new cases, lung major threat to public health. The poor survival rates patients can be attributed stealth progression late diagnosis. For long time, intrusive tissue biopsy has been considered gold standard diagnosis subtyping; however, intrinsic limitations cannot overlooked. In addition being invasive costly, it also suffers from in sensitivity specificity, not suitable repeated sampling, provides restricted information about tumor molecular landscape, inaccessible several cases. To cope with this, advancements diagnostic technologies, such as liquid biopsy, have shown great prospects. Liquid an innovative non-invasive approach which cancer-related components called biomarkers are detected body fluids, blood, urine, saliva others. It offers less alternative potential applications routine screening, predicting treatment outcomes, evaluating effectiveness, detecting residual disease, or disease recurrence. A large research articles indicated extracellular vesicles (EVs) ideal biopsy. EVs heterogeneous collection membranous nanoparticles diverse sizes, contents, surface markers. play critical role pathophysiological states gained prominence prognostic multiple diseases, including cancer. this review, we provide detailed overview EV-based Moreover, highlights strengths weaknesses various contemporary techniques EV isolation analysis challenges that need addressed ensure widespread clinical application biopsies summary, present interesting opportunities development novel platforms cancer, one most abundant cancers millions deaths worldwide.

Language: Английский

Citations

2