The mediating role of insulin resistance in the association between inflammatory score and MAFLD: NHANES 2017–2018

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(10)

Published: Oct. 1, 2024

The association between inflammatory score, insulin resistance (IR), and metabolic-associated fatty liver disease (MAFLD) is inconclusive.

Language: Английский

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Role of C-Reactive Protein as a Predictor of Early Revascularization and Mortality in Advanced Peripheral Arterial Disease

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 815 - 815

Published: Jan. 26, 2025

Background: Elevated high-sensitivity C-reactive protein (hsCRP) levels are associated with poor cardiovascular outcomes, particularly in patients advanced peripheral arterial disease (PAD). This study aimed to assess the impact of hsCRP on clinical characteristics and long-term outcomes a cohort PAD patients. Methods: A total 346 were enrolled stratified into two groups based their median level (Group 1: <0.32 mg/dL, Group 2: >0.32 mg/dL). The followed for mean 102.70 ± 44.13 months. Their characteristics, comorbidities, events, including myocardial and/or revascularization, ischemia, death, analyzed. evaluated composite endpoints: major adverse events (MACEs) (MAPEs). MACEs comprised fatal cerebral cardiac infarction, acute occlusion, reperfusion. MAPEs included carotid reperfusion, lower limb revascularization. Results: 2 had higher body mass index, waist circumference, waist–hip ratio compared those 1 (all p < 0.05). Inflammatory markers, fibrinogen erythrocyte sedimentation rate, significantly elevated (both 0.01). While overall incidence revascularization was similar between groups, these interventions occurred earlier (28.24 38.87 months vs. 67.04 49.97 months, = 0.004; HR: 2.015, 95% CI: 1.134–3.580, 0.017). comparable number, but (36.60 37.35 66.19 48.18 0.01; 1.99, 1.238–3.181, 0.004). Similarly, an onset (40.31 38.95 55.89 46.33 0.04; 1.62, 0.983–1.987, 0.062). 169 deaths recorded during follow-up. exhibited mortality rate (56% 42%, 0.01) trend (76.58 43.53 84.86 5.18 months), although this difference did not reach statistical significance (p 0.22). Conclusions: (>0.32 mg/dL) worse profile PAD. experienced MACEs, MAPEs. rates also higher, highlighting prognostic value population.

Language: Английский

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Impact of Different Low-Volume Concurrent Training Regimens on Cardiometabolic Health, Inflammation, and Fitness in Obese Metabolic Syndrome Patients

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 561 - 561

Published: Jan. 31, 2025

Background/Objectives: Evidence supports the benefits of concurrent training (CT), which combines endurance and resistance exercises, for enhancing health physical fitness. Recently, low-volume, time-efficient exercise approaches such as low-volume high-intensity interval (LOW-HIIT), whole-body electromyostimulation (WB-EMS), single-set (1-RT) have gained popularity their feasibility efficacy in improving various outcomes. This study investigated effects CT, focusing on (1) whether order affects cardiometabolic health, inflammation, fitness adaptations (2) combination, LOW-HIIT plus WB-EMS or 1-RT, yields better results. Methods: Ninety-three obese metabolic syndrome (MetS) patients undergoing caloric restriction were randomly assigned to four groups performing different CT protocols over 12 weeks. Outcomes included cardiometabolic, inflammatory, parameters. Results: In both combinations, no significant differences found regarding order. However, pooled 1-RT group achieved superior improvements blood pressure, lipids, inflammation markers (CRP, hsCRP), MetS severity score, overall compared combination. Compared previous studies using these modalities individually, appeared further reduce whereas combined with was less effective potentially due interference between modalities. Conclusions: While appears be a viable option individuals unable perform traditional training, findings suggest prioritizing maximize These highlight importance tailored prescriptions need research into optimizing diverse populations.

Language: Английский

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Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 20, 2025

The inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. However, the relationship between and cardiovascular disease (CVD) unclear. Thus, we aimed to explore association with CVD, well evaluate whether adhering healthy lifestyle could alleviate this association. We analyzed 6,164 participants aged ≥45 years who entered prospective cohort study China Longitudinal Study Health Retirement (CHARLS) 2011 2012 were followed up CVD incidence untill 2018. was measured by summing Z-scores C-reactive protein white blood cell count at baseline. calculated four factors, smoking status, alcohol consumption, body mass index, sleep duration. Cox proportional hazard models utilized calculate ratios (HRs) 95% confidence intervals (CIs) CVD. During 7-year follow-up period, there 761 incident cases Compared lowest tertiles, highest associated an elevated risk (HR = 1.25, CI 1.04-1.49). unhealthy lifestyle, adhered inversely 0.74, 0.60-0.93). Of note, when higher no longer significantly correlated 1.00, 0.76-1.34). Additionally, multiplicative interaction detected (p <0.05). incidence, but adherence may mitigate adverse among middle-aged older participants.

Language: Английский

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Metabolic syndrome, high-sensitivity C-reactive protein and the risk of heart failure: the Kailuan cohort study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Background Metabolic syndrome (MetS) and elevated high-sensitivity C-reactive protein (hs-CRP) have been identified as risk factors for heart failure (HF) in some studies. However, little was known about the co-exposure of MetS inflammation to HF. We aimed investigate combined effect high hs-CRP levels on incident Methods The study included 94,841 participants without HF selected from Kailuan cohort 2006 (the baseline) then followed up until 31 December 2020. Participants were divided into four groups based presence (&gt;3mg/L) at baseline: MetS-CRP- (n=53,937), MetS-CRP+ (n=10,338), MetS+CRP- (n=23,521), MetS+CRP+ (n=7,045). Cox regression models used analyze association with Statistical significance defined a two-tailed P value &lt; 0.05. Results mean age 51.5 ± 12.5 years, 75,976 (80.0%) male. During 13.1 years follow-up, 3,058 diagnosed incidence rate 1.69/1000pys, 2.95/1000pys, 3.27/1000pys, 5.33/1000pys. HR MetS-CRP+, MetS+CRP-, 1.29 (95% CI, 1.15-1.45), 1.40 1.29-1.53), 1.85 1.65-2.06), respectively, compared MetS-CRP-. After stratification by (p interaction 0.01), group, group 2.17 1.83-2.57) 60 1.53 1.32-1.78) ≥ years. There an between ues antihypertension medication &lt;0.01). Compared MetS-CRP-, increased 1.38-fold 1.12-1.70) use 2.00-fold 1.75-2.27) use. Conclusions combination associated Chinese population. Clinical trial registration https://www.chictr.org.cn , identifier ChiCTR-TNRC-11001489.

Language: Английский

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Metabolic syndrome prevalence in Mexican individuals exposed to polycyclic aromatic hydrocarbons and their association with an increased risk of cardiovascular events

Drug and Chemical Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Dec. 29, 2024

Polycyclic aromatic hydrocarbons (PAHs) are an organic chemical family produced during incomplete combustion of materials. Besides, PAHs associated with different detrimental health effects. Therefore, this research was aimed to assess the association between exposure, metabolic syndrome (MetS) prevalence, and cardiovascular risk in a Mexican population. Urinary 1-hydroxypyrene (1-OHP) exposure biomarker quantified. MetS prevalence defined using National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) International Diabetes Federation (IDF) criteria. Also, we used atherogenic index plasma (AIP) as biomarker. The mean urinary 1-OHP level quantified 2.50 ± 1.25 µmol/mol creatinine. found 35% (n = 222) 31% 197) NCEP IDF criteria, respectively. AIP value 0.32 0.15. Furthermore, data analysis showed robust associations PAH (urinary concentrations), (AIP). real significance findings study needs be clarified completely, diseases represent critical challenge contaminated zones developing countries such Mexico.

Language: Английский

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