Role and Diagnostic Significance of Apolipoprotein D in Selected Neurodegenerative Disorders DOI Creative Commons
Agata Kolanek,

Roman Cemaga,

Mateusz Maciejczyk

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2814 - 2814

Published: Dec. 14, 2024

The World Health Organization in 2021 ranked Alzheimer’s disease and other dementias as the seventh leading cause of death globally. Neurodegenerative disorders are progressive, intractable, often fatal diseases. Early diagnosis may allow patients to enjoy prolonged survival with attenuated symptomatology because early intervention. Hence, further research on finding non-invasive biomarkers neurodegenerative diseases is warranted. Apolipoprotein D (ApoD) a glycoprotein involved lipid metabolism, oxidative stress regulation, inflammation. It expressed various body fluids regions central nervous system. ApoD’s roles neuroprotection, transport, anti-inflammatory processes crucial far prevention pathologies concerned. This review aims summarize background knowledge ApoD, it covers studies indexed PubMed, Scopus, Web Science databases. discusses evidence for multifaceted ApoD mechanisms pathogenesis multiple sclerosis, disease, Parkinson’s disease. be specific, sensitive, easily obtained, cost-effective biomarker its applications diagnostic practices, treatment strategies, advancing disorders’ management.

Language: Английский

A Genetic and Environmental Analysis of Inflammatory Factors in Chronic Widespread Pain Using the TwinsUK Cohort DOI Creative Commons
Stacey S. Cherny, Gregory Livshits, Frances M. K. Williams

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 155 - 155

Published: Jan. 21, 2025

Chronic widespread musculoskeletal pain (CWP), a significant health issue affecting individuals and society, is often diagnosed as part of fibromyalgia but not generally considered inflammatory. This study investigated the relationship between blood-based inflammatory factors CWP in 904 from TwinsUK cohort. Participants, free major conditions, completed questionnaires to assess CWP. Plasma samples were analysed using Olink panel, alongside assays for C-reactive protein (CRP) Apolipoproteins A1 B. No associations observed after adjusting multiple testing. Twin modelling revealed heritability both factors, with genetic covariance several factors. Additive Bayesian network suggested that any association mediated by body mass index (BMI). These findings emphasize complexity its potential reliance on beyond inflammation, such BMI, which strongly correlates CRP other markers. Future research should explore additional molecular, genetic, environmental contributors variability investigate clinical or covariates may obscure relationships providing more comprehensive understanding this multifaceted condition.

Language: Английский

Citations

0
Association between monocyte-high-density lipoprotein cholesterol ratio and mortality in a population with asthma: a cohort study DOI Creative Commons
Qin Zhang,

Jing Xia,

Rongjuan Zhuang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0
An unusual phenotype of hereditary AApoAI amyloidosis caused by a novel Asp20Tyr substitution is linked to pH-dependent aggregation of apolipoprotein A-I DOI
Tatiana Prokaeva,

Shobini Jayaraman,

Elena S. Klimtchuk

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167820 - 167820

Published: March 1, 2025

Language: Английский

Citations

0
Apolipoprotein A-I: Potential Protection Against Intestinal Injury Induced by Dietary Lipid DOI Creative Commons

Jue-Xin Wang,

Shijia Yu,

Gang Huang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5711 - 5721

Published: Aug. 1, 2024

The intestinal barrier system protects the human body from harmful factors, by continuously renewing epithelium, tight junctions and enteric microbes. However, dietary fat can harm epithelial enhancing gut permeability. In recent years, Apolipoprotein A-I has attracted much attention because of its anti-inflammatory properties. Numerous studies have demonstrated that regulate mucosal immune cells, inhibit progression inflammation, promote proliferation repair, maintain physical function; it also angiogenesis, thereby improving local circulation. This article is intended to elucidate mechanism which improves damage caused review role in maintaining homeostasis.

Language: Английский

Citations

1
The functions of apolipoproteins and lipoproteins in health and disease DOI Creative Commons
Zijun Ma, Jixin Zhong, Wei Tu

et al.

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Oct. 28, 2024

Lipoproteins and apolipoproteins are crucial in lipid metabolism, functioning as essential mediators the transport of cholesterol triglycerides being closely related to pathogenesis multiple systems, including cardiovascular. a (Lp(a)), unique subclass lipoproteins, is low-density lipoprotein(LDL)-like particle with pro-atherosclerotic pro-inflammatory properties, displaying high heritability. More more strong evidence points possible link between amounts Lp(a) cardiac conditions like atherosclerotic cardiovascular disease (ASCVD) aortic stenosis (AS), making it risk factor for heart diseases. In recent years, Lp(a)'s role other diseases, neurological disorders cancer, has been increasingly recognized. Although therapies aimed at lipoprotein (LDL-C) high-density (HDL-C) have achieved significant success, elevated levels remain clinical management problem. Despite limited efficacy current lipid-lowering therapies, major advances new Lp(a)-lowering significantly advanced field. This review, grounded pathophysiology seeks summarize wide-ranging connections lipoproteins (such LDL-C HDL-C) various alongside latest developments, special emphasis placed on pivotal disease, while also examining its future potential mechanisms conditions. Furthermore, this review discusses highlights emerging treatments, advocates further exploration into pathogenic therapeutic target, proposing secondary prevention strategies high-risk individuals.

Language: Английский

Citations

1
Role and Diagnostic Significance of Apolipoprotein D in Selected Neurodegenerative Disorders DOI Creative Commons
Agata Kolanek,

Roman Cemaga,

Mateusz Maciejczyk

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2814 - 2814

Published: Dec. 14, 2024

The World Health Organization in 2021 ranked Alzheimer’s disease and other dementias as the seventh leading cause of death globally. Neurodegenerative disorders are progressive, intractable, often fatal diseases. Early diagnosis may allow patients to enjoy prolonged survival with attenuated symptomatology because early intervention. Hence, further research on finding non-invasive biomarkers neurodegenerative diseases is warranted. Apolipoprotein D (ApoD) a glycoprotein involved lipid metabolism, oxidative stress regulation, inflammation. It expressed various body fluids regions central nervous system. ApoD’s roles neuroprotection, transport, anti-inflammatory processes crucial far prevention pathologies concerned. This review aims summarize background knowledge ApoD, it covers studies indexed PubMed, Scopus, Web Science databases. discusses evidence for multifaceted ApoD mechanisms pathogenesis multiple sclerosis, disease, Parkinson’s disease. be specific, sensitive, easily obtained, cost-effective biomarker its applications diagnostic practices, treatment strategies, advancing disorders’ management.

Language: Английский

Citations

0