Mid-life: a critical window for intervention during aging

Published: Jan. 14, 2025

Mid-life represents a pivotal period marked by profound physiological and metabolic transitions, increasing susceptibility to chronic diseases. This review explores the molecular systemic underpinnings of mid-life transition integrating insights from recent studies that elucidate aging-associated changes in plasma proteome, immune system, adipose tissue remodeling, cellular senescence. Nonlinear waves proteomic alterations have been identified as critical transitions inflammatory hormonal pathways. In addition, sex-specific aging trajectories linked adaptive immunity decline innate activation vulnerabilities mid-life. Moreover, tissue’s central role has established its early remodeling cytokine secretion drive stress. Furthermore, Glb1-2A-mCherry reporter introduced monitor aging, identifying crucial phase for cardiac hypertrophy senescence-induced inflammation. Collectively, these findings our understanding underscoring interplay between processes health, with emerging window intervention. also underscores biomarkers therapeutic strategies alleviate challenges mid-life, thereby promoting healthy aging.

Language: Английский

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Sex-specific disease resistance and gut microbiota dynamics in juvenile common carp (Cyprinus carpio) following viral infection

Water Biology and Security, Journal Year: 2025, Volume and Issue: unknown, P. 100410 - 100410

Published: April 1, 2025

Language: Английский

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Diminishing Reactogenicity with Preserved Immunogenicity in COVID-19 Vaccines: A Longitudinal Observation from Primary to Updated Booster Vaccine Cohorts

Journal of Infection and Public Health, Journal Year: 2025, Volume and Issue: unknown, P. 102794 - 102794

Published: April 1, 2025

Encouraging annual updated COVID-19 vaccinations for high-risk populations is crucial public health. However, concerns about significant reactogenicity persist, contributing to vaccine hesitancy. To investigate evolving and immunogenicity, we conducted a longitudinal analysis across three cohorts. The Primary Vaccine Cohort, receiving wild-type (WT) 1st 3rd doses WT-BA.4/5 bivalent vaccine; the XBB.1.5 Monovalent (MoV) Cohort; ongoing JN.1 MoV Cohort were investigated. Reactogenicity was assessed using electronic diaries eight days, serological responses measured through quantitative anti-spike protein antibody (Sab) assay. Plaque reduction neutralization testing (PRNT) performed against WT SARS-CoV-2 vaccine-specific variants. A total of 290 participants with 690 1222 sampling points included. Total symptom scores decreased serially from dose MoV, changes pronounced in younger age group (< 45 years; Spearman r = -0.13, P 0.008). Changes not evident older (≥ years) consistently low reactogenicity. Severe reactions also steadily declined 26.2 % (WT 1st) 3.3 (JN.1 MoV). Serological revealed plateauing post-vaccination Sab titers increasing pre-vaccination levels robust PRNT strains. Age negatively correlated after but subsequent doses. Multivariable found no association between immunogenicity. observed decline reactogenicity, alongside sustained immunological responses, supports safety efficacy booster vaccination programs.

Language: Английский

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Targeting the Senescent Tumor Microenvironment to Sensitize Immunotherapy

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 139, P. 260 - 271

Published: April 28, 2025

The tumor microenvironment (TME) plays a pivotal role in cancer progression, metastasis, and therapeutic resistance. Cellular senescence within the TME, characterized by irreversible growth arrest senescence-associated secretory phenotype (SASP), profoundly impacts biology immunotherapy efficacy. senescent TME promotes growth, invasion, metastasis through complex interactions between cells, SASP factors, extracellular matrix (ECM). Simultaneously, senescence-induced alterations immune cell function, including T exhaustion, macrophage polarization, impaired natural killer (NK) cytotoxicity, contribute to an immunosuppressive niche that hinders immunosurveillance fosters evasion. Mounting evidence suggests is critical mediator of resistance checkpoint inhibitors (ICIs). Senescence-associated changes dampen antitumor immunity reducing CD8+ infiltration functionality while promoting accumulation populations such as regulatory cells (Tregs) myeloid-derived suppressor (MDSCs). Consequently, strategies targeting have emerged promising approaches enhance ICI Senolytic agents, inhibitors, combinatorial therapies aimed at eliminating modulating SASP, reprogramming shown potential preclinical models sensitize tumors immunotherapy. As our understanding evolves, it becoming increasingly clear multifaceted approach integrating TME-targeted interventions with necessary overcome improve patient outcomes. Future research should focus on elucidating molecular mechanisms underlying senescence-driven resistance, identifying robust biomarkers predict treatment response, developing novel synergize ICIs. By harnessing approaches, we can expand scope efficacy immunotherapy, ultimately leading improved survival quality life for patients.

Language: Английский

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Molecular mechanisms and therapeutic strategies of gut microbiota modulation in Sarcopenia (Review)

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(3)

Published: Dec. 17, 2024

Sarcopenia is an age-related disease that characterized by a decline in muscle mass and function with significant epidemiological clinical implications. In recent years, gut microbiota has gained attention as important regulatory factor human health. To the best of our knowledge, this first study to introduce definition background sarcopenia analyze potential impact on metabolism growth, including aspects such metabolites, protein synthesis energy metabolism. Additionally, article summarizes current research progress interventions for treatment sarcopenia, probiotics, prebiotics fecal transplantation discusses future directions therapeutic strategies.

Language: Английский

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