Experimental Eye Research, Journal Year: 2024, Volume and Issue: 249, P. 110144 - 110144
Published: Nov. 1, 2024
Language: Английский
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 29, 2025
The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates regulating the body’s immune response, cell proliferation, apoptosis among a series of processes. Recent studies have revealed close connection between lipid metabolism. gut microbiota plays significant role host Growing evidence suggests an inseparable link signaling. This review summarizes relationship metabolism disorders, well interaction AhR, exploring how this modulates
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, specific downstream targets mechanisms by which AhR melanoma remain insufficiently understood. Melanoma samples from Cancer Genome Atlas (TCGA) normal skin tissues Genotype-Tissue Expression (GTEx) database were analyzed to identify differentially expressed genes, intersected with a curated list AhR-related genes. Prognostic models subsequently developed, feature genes identified. Advanced methodologies, including Gene Set Enrichment Analysis (GSEA) infiltration analysis, employed explore biological significance these stability machine learning relationship between gene expression infiltrating cells validated using three independent datasets. A mouse model was used validate dynamic changes during tumor progression. selected drug sensitivity, as well non-coding RNA interactions, thoroughly investigated. Our analysis identified robust prognostic model, four (MAP2K1, PRKACB, KLF5, PIK3R2) emerging key contributors GSEA revealed that are involved primary immunodeficiency. Immune demonstrated enrichment CD4+ naïve memory T cells, macrophages (M0 M2), CD8+ melanoma, all associated Importantly, diagnostic power relevance additional In Map2k1 Prkacb mRNA levels exhibited progressive increase progression, supporting their role advancement. This study presents comprehensive highlighting MAP2K1, PIK3R2 markers potential therapeutic targets. integration bioinformatics provides framework for enhancing evaluation patients offers new avenues development treatments, particularly those resistant current immunotherapies.
Language: Английский
Citations
0
International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(2), P. 222 - 222
Published: Feb. 5, 2025
Ozone, a critical air pollutant, has been shown to lead systemic inflammation that can alter bodily functions, including hormone secretion, fertility, and the hypothalamic–pituitary–gonadal (HPG) axis. This study aimed quantify changes in production follicle development after acute exposure ozone using an animal model identify potential mechanisms underlying observed effects of pollution exposures on fertility secretion. To accomplish this, regularly cycling 8-week-old female C57BL/6J mice were exposed 2 ppm or filtered (control) for 3 h day proestrus. Blood, ovaries, brain tissues, pituitary glands collected at 4 evaluate levels, ovarian distribution, gene expression. Ovaries also harvested 24 post-exposure. We found exposure, had significantly higher (30%) circulating estradiol levels than air. effect was accompanied by decrease mRNA expression gonadotropin genes (LH, FSH) gonadotropin-releasing gland. Analysis tissue showed no significant composition steroidogenesis genes. conclude affects sex disrupts HPG Future studies addressing chronic long-term are needed elucidate which ambient endocrine function.
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118015 - 118015
Published: March 29, 2025
Language: Английский
Citations
0
Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 191, P. 110144 - 110144
Published: April 14, 2025
BCOR (BCL-6 corepressor) rearranged small round cell sarcoma (BRS) represents an uncommon soft tissue malignancy, frequently characterized by the BCOR::CCNB3 fusion. Other noteworthy fusions include BCOR::MAML3, BCOR::CLGN, BCOR::MAML1, ZC3H7B::BCOR, KMT2D::BCOR, CIITA::BCOR, RTL9::BCOR, and AHR::BCOR. The gene plays a pivotal role in Polycomb Repressive Complex 1 (PRC1), essential for histone modification silencing. It interfaces with group RING finger homolog (PCGF1). This study employed comprehensive silico methodologies to investigate structural functional effects of fusion events BRS. analysis revealed significant alterations domain architecture BCOR, which resulted loss BCL6-regulated transcriptional repression. Furthermore, IUPred3 prediction indicated increase disorder C-terminal regions proteins. A detailed physicochemical properties ProtParam decrease isoelectric point, stability, hydrophobicity. protein structures predicted AlphaFold3 using PRODIGY algorithm statistically deviations binding affinities BCOR-PCGF1 dimers non-canonical PRC1 variant tetramer compared wild-type BCOR. findings provide summary elucidation proteome associated BRS, suggesting substantial impact on stability functionality proteins, thereby contributing oncogenic mechanisms underlying In this study, we first compilation comparative known BRS introduce new approach enhance better understanding molecular basis
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2024, Volume and Issue: 249, P. 110144 - 110144
Published: Nov. 1, 2024
Language: Английский
Citations
0