Different types of cell death and their interactions in myocardial ischemia–reperfusion injury

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 5, 2025

Myocardial ischemia-reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow restored to the heart tissue following ischemia-induced damage. Cardiomyocyte cell death, particularly through apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, pivotal myocardial I/R injury. Preventing death during of vital for improving ischemic cardiomyopathy. These multiple forms can occur simultaneously, interact each other, contribute complexity In this review, we aim provide comprehensive summary key molecular mechanisms regulatory patterns involved these five types We will also discuss crosstalk intricate interactions among mechanisms, highlighting interplay between different death. Furthermore, explore specific molecules or targets that participate pathways elucidate their action. It important note manipulating distinct processes may have significant impact on reducing By enhancing researchers' understanding injury, review aims pave way development novel interventions cardio-protection affected by

Language: Английский

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Mitochondrial signaling pathways and their role in cancer drug resistance

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329

Published: Aug. 5, 2024

Language: Английский

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The potential of natural herbal plants in the treatment and prevention of non-small cell lung cancer: An encounter between ferroptosis and mitophagy

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119555 - 119555

Published: Feb. 1, 2025

Language: Английский

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Calcium Signals as Regulators of Ferroptosis in Cancer

Cell Calcium, Journal Year: 2024, Volume and Issue: 124, P. 102966 - 102966

Published: Oct. 30, 2024

Language: Английский

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Berberine Alleviates Tendinopathy by Suppressing the cGAS-STING Pathway and Relieving Ferroptosis

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 767, P. 151923 - 151923

Published: May 1, 2025

Language: Английский

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Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 298, P. 118269 - 118269

Published: May 10, 2025

Language: Английский

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The role of mitochondria in aging, cell death, and tumor immunity

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 23, 2024

Mitochondria are essential double-membrane organelles with intricate structures and diverse functions within cells. Under normal physiological conditions, mitochondria regulate cellular metabolism maintain energy homeostasis via the electron transport chain, mediate stem cell fate, modulate reactive oxygen species production, playing a pivotal role in supply lifespan extension. However, mitochondrial dysfunction can lead to various pathological changes, including aging, necrosis, dysregulated tumor immunity, initiation progression of cancer. Moreover, abnormal is closely associated numerous diseases, such as neurodegenerative disorders, metabolic syndromes, cancers. In recent years, targeting has emerged promising anticancer strategy, aiming for therapeutic benefits. Nonetheless, approaches face limitations, low delivery efficiency insufficient specificity. This review systematically explores structure function, their roles, potential challenges mitochondria-targeted strategies cancer therapy, providing insights future research directions.

Language: Английский

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Ferroptosis-related LINC02535/has-miR-30c-5p/EIF2S1 axis as a novel prognostic biomarker involved in immune infiltration and progression of PDAC

Cellular Signalling, Journal Year: 2024, Volume and Issue: 123, P. 111338 - 111338

Published: Aug. 6, 2024

Language: Английский

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