One Health Approach to the Computational Design of a Lipoprotein-Based Multi-Epitope Vaccine Against Human and Livestock Tuberculosis DOI Open Access
Robert Adamu Shey, Gordon Takop Nchanji,

Tangan Yanick Aqua Stong

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1587 - 1587

Published: Feb. 13, 2025

Tuberculosis (TB) remains a major cause of ill health and one the leading causes death worldwide, with about 1.25 million deaths estimated in 2023. Control measures have focused principally on early diagnosis, treatment active TB, vaccination. However, widespread emergence anti-tuberculosis drug resistance public threat to progress made global TB care control. Moreover, Bacillus Calmette-Guérin (BCG) vaccine, only licensed vaccine against children, has been use for over century, there considerable debates concerning its effectiveness A multi-epitope would be an invaluable tool attain Global Plan End 2023-2030 target. rational approach that combines several B-cell T-cell epitopes from key lipoproteins was adopted design novel candidate. In addition, interactions TLR4 were implemented assess ability elicit innate immune response. The conservation selected proteins suggests possibility cross-protection line One Health disease candidate predicted both antigenic immunogenic, simulation analyses demonstrated humoral cellular responses. Protein-protein docking normal-mode efficient binding stable interaction. This study provides promising vaccines human livestock tuberculosis. Overall, designed immunogenicity safety features warrant further experimental validation vitro vivo.

Language: Английский

Synthesis of an Adjuvant-Free Single Polypeptide-Based Tuberculosis Subunit Vaccine that Elicits In Vivo Immunogenicity in Rats DOI

Supriya Phogat,

Jyoti Yadav,

Darshna Chaudhary

et al.

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

1
One Health Approach to the Computational Design of a Lipoprotein-Based Multi-Epitope Vaccine Against Human and Livestock Tuberculosis DOI Open Access
Robert Adamu Shey, Gordon Takop Nchanji,

Tangan Yanick Aqua Stong

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1587 - 1587

Published: Feb. 13, 2025

Tuberculosis (TB) remains a major cause of ill health and one the leading causes death worldwide, with about 1.25 million deaths estimated in 2023. Control measures have focused principally on early diagnosis, treatment active TB, vaccination. However, widespread emergence anti-tuberculosis drug resistance public threat to progress made global TB care control. Moreover, Bacillus Calmette-Guérin (BCG) vaccine, only licensed vaccine against children, has been use for over century, there considerable debates concerning its effectiveness A multi-epitope would be an invaluable tool attain Global Plan End 2023-2030 target. rational approach that combines several B-cell T-cell epitopes from key lipoproteins was adopted design novel candidate. In addition, interactions TLR4 were implemented assess ability elicit innate immune response. The conservation selected proteins suggests possibility cross-protection line One Health disease candidate predicted both antigenic immunogenic, simulation analyses demonstrated humoral cellular responses. Protein-protein docking normal-mode efficient binding stable interaction. This study provides promising vaccines human livestock tuberculosis. Overall, designed immunogenicity safety features warrant further experimental validation vitro vivo.

Language: Английский

Citations

0