Fecal Microbiota Transplantation: Insights into Colon Carcinogenesis and Immune Regulation

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6578 - 6578

Published: Nov. 1, 2024

Colorectal cancer (CRC) constitutes a significant global health challenge, with recent studies underscoring the pivotal role of gut microbiome in its pathogenesis and progression. Fecal microbiota transplantation (FMT) has emerged as compelling therapeutic approach, offering potential to modulate microbial composition optimize treatment outcomes. Research suggests that specific bacterial strains are closely linked CRC, influencing both clinical management interventions. Moreover, microbiome's impact on immunotherapy responsiveness heralds new avenues for personalized medicine. Despite promise FMT, safety concerns, particularly immunocompromised individuals, remain critical issue. Clinical outcomes vary widely, influenced by genetic predispositions methodologies employed. Additionally, rigorous donor selection screening protocols paramount minimize risks maximize efficacy. The current body literature advocates establishment standardized further trials substantiate FMT's CRC management. As our understanding deepens, FMT is poised become cornerstone treatment, imperative continued research validation.

Language: Английский

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Current and Emerging Treatment Options for Pancreatic Cancer: A Comprehensive Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1129 - 1129

Published: Feb. 10, 2025

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes death worldwide, and its global burden has increased significantly over past few years. The incidence pancreatic cancer also in United States, most this increase attributed to population’s aging process addition rise prevalence risk factors such as obesity, diabetes, smoking, alcohol intake. Most patients with present advanced unresectable or metastatic disease. Only a at an early stage localized disease, multidisciplinary approach required maximize survival outcomes. surgical option for surgery’s safety efficacy have been improved recent years due increasing use minimally invasive techniques. Moreover, systematic chemotherapy used had significant impact on survival. More recently, neoadjuvant therapy along radiation therapy, optimizing among those patients. Targeted therapies introduced based genetic testing shown promising results. immune checkpoint inhibitors targeted agents PARP vaccines emerged optimal results terms To conclude, considered disease poor long-term survival; however, developments pharmacotherapy changed treatment outcomes Our review summarizes ongoing therapeutic options local cancer. It new state-of-the-art that are trials, which can change perspective.

Language: Английский

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The causal dance: trimethylamine N-oxide, obesity, and acute pancreatitis in pathophysiological harmony

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 26, 2025

Language: Английский

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The Gut Microbiome and Its Multifaceted Role in Cancer Metabolism, Initiation, and Progression: Insights and Therapeutic Implications

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: April 1, 2025

This review summarizes the intricate relationship between microbiome and cancer initiation development. Microbiome alterations impact metabolic pathways, immune responses, gene expression, which can accelerate or mitigate progression. We examine how dysbiosis affects tumor growth, metastasis, treatment resistance. Additionally, we discuss potential of microbiome-targeted therapies, such as probiotics fecal microbiota transplants, to modulate metabolism. These interventions offer possibility reversing controlling progression, enhancing efficacy traditional treatments like chemotherapy immunotherapy. Despite promising developments, challenges remain in identifying key microbial species pathways validating therapies through large-scale clinical trials. Nonetheless, intersection research development presents an exciting frontier for innovative therapies. offers a fresh perspective on by integrating insights, highlighting interdisciplinary enhance our understanding progression strategies.

Language: Английский

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Role of Metabolites in Mediating the Effect of Gut Microbes on Pancreatic Cancer a Two-Step Mendelian Randomization Study

Published: Jan. 1, 2024

Language: Английский

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Molecular and cellular mechanisms of PDAC progression based on RETN-CAP1-mediated macrophage-fibroblast crosstalk: Action of ITGB5 and ITGB1 recombinant proteins

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 290, P. 139078 - 139078

Published: Dec. 22, 2024

Language: Английский

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