International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13413 - 13413
Published: Dec. 14, 2024
Ferroptosis,
a
novel
form
of
cell
death
discovered
in
recent
years,
is
typically
accompanied
by
significant
iron
accumulation
and
lipid
peroxidation
during
the
process.
This
article
systematically
elucidates
how
tumor
metabolic
reprogramming
affects
ferroptosis
process
cells.
The
paper
outlines
basic
concepts
physiological
significance
ferroptosis,
delves
into
specific
regulatory
mechanisms
glucose
metabolism,
protein
metabolism
on
ferroptosis.
We
also
explore
complex
changes
microenvironment
further
influence
response
cells
to
Glucose
modulates
sensitivity
influencing
intracellular
energetic
status
redox
balance;
involving
amino
acid
synthesis,
plays
crucial
role
initiation
progression
ferroptosis;
relationship
between
primarily
manifests
generation
elimination
peroxides.
review
aims
provide
new
perspective
regulate
through
reprogramming,
with
ultimate
goal
offering
theoretical
basis
for
developing
therapeutic
strategies
targeting
Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(6)
Published: March 1, 2025
Metastasis
is
the
primary
cause
of
cancer
mortality.
It
responsible
for
90%
all
cancer-related
deaths.
Intercellular
communication
a
crucial
feature
underlying
metastasis
and
progression.
Cancerous
tumors
secrete
membrane-derived
small
extracellular
vesicles
(30-150
nm)
into
their
milieu.
These
tiny
organelles,
known
as
exosomes,
facilitate
intercellular
by
transferring
bioactive
molecules.
exosomes
harbor
different
cargos,
such
proteins,
nucleic
acids,
lipids,
that
mediate
multifaceted
functions
in
various
oncogenic
processes.
Of
note,
amount
lipids
multifold
higher
than
other
cargos.
Most
studies
have
investigated
role
exosomes'
protein
acid
content
processes,
while
lipid
cargo
pathophysiology
remains
largely
obscure.
We
conducted
an
extensive
literature
review
on
progression,
specifically
addressing
topic
exosomal
involvement
This
aims
to
shed
light
contents
metastasis.
In
this
context,
signaling
pathways,
immunomodulation,
energy
production
cell
survival
provides
insights
overcoming
progression
Seminars in Cancer Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Elevated
lipid
metabolism
is
one
of
hallmarks
malignant
tumors.
Lipids
not
only
serve
as
essential
structural
components
biological
membranes
but
also
provide
energy
and
substrates
for
the
proliferation
cancer
cells
tumor
growth.
Cancer
meet
their
needs
by
coordinating
processes
absorption,
synthesis,
transport,
storage,
catabolism.
As
research
in
this
area
continues
to
deepen,
numerous
new
discoveries
have
emerged,
making
it
crucial
scientists
stay
informed
about
developments
metabolism.
In
review,
we
first
discuss
relevant
concepts
theories
or
assumptions
that
help
us
understand
-based
therapies.
We
then
systematically
summarize
latest
advancements
including
mechanisms,
novel
targets,
up-to-date
pre-clinical
clinical
investigations
anti-cancer
treatment
with
targeted
drugs.
Finally,
emphasize
emerging
directions
therapeutic
strategies,
future
prospective
challenges.
This
review
aims
insights
guidance
field
Cancers,
Journal Year:
2025,
Volume and Issue:
17(5), P. 817 - 817
Published: Feb. 26, 2025
Despite
multimodal
therapies,
the
treatment
of
glioblastoma
remains
challenging.
In
addition
to
very
complex
mechanisms
cancer
cells,
including
specialized
phenotypes
that
enable
them
proliferate,
invade
tissues,
and
evade
immunosurveillance,
they
exhibit
a
pronounced
resistance
chemo-
radiotherapy.
More
advanced
tumors
create
hypoxic
environment
supports
their
proliferation
survival,
while
robust
angiogenesis
ensures
constant
supply
nutrients.
GBM,
these
structures
are
contribute
creation
maintenance
highly
immunosuppressive
microenvironment
promotes
tumor
growth
immune
escape.
addition,
high
accumulation
tumor-infiltrating
leukocytes
other
expression
checkpoint
molecules,
low
mutational
burden,
i.e.,
number
neoantigens,
hallmarks
GBM
challenge
therapeutic
approaches.
Here,
we
review
exploits
support
potential
treatments.
These
include
new
chemotherapeutics,
treating
fields,
small
compounds
targeting
or
blockers
tyrosine
kinases
inhibit
cell
survival.
focus
on
immunotherapies
such
as
blockade
in
particular
vaccination
with
dendritic
cells
CAR-T
which
can
either
kill
directly
bypass
immunosuppression
by
modulating
boosting
patient's
own
response.
Immune Network,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 1, 2025
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death,
is
driven
by
lipid
peroxidation
and
shaped
metabolic
antioxidant
pathways.
In
immune
cells,
ferroptosis
susceptibility
varies
types,
composition,
demands,
influencing
responses
in
cancer,
infections,
autoimmune
diseases.
Therapeutically,
targeting
holds
promise
cancer
immunotherapy
enhancing
antitumor
immunity
or
inhibiting
immunosuppressive
cells.
This
review
highlights
the
pathways
underlying
ferroptosis,
its
regulation
dual
role
tumor
progression
immunity,
context-dependent
therapeutic
implications
for
optimizing
treatment.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 5, 2025
Ferroptosis
is
a
novel
form
of
cell
death
that
uniquely
requires
iron
and
characterized
by
accumulation,
the
generation
free
radicals
leading
to
oxidative
stress,
formation
lipid
peroxides,
which
distinguish
it
from
other
forms
death.
The
regulation
ferroptosis
extremely
complex
closely
associated
with
spectrum
diseases.
Sirtuin
1
(SIRT1),
NAD
+
-dependent
histone
deacetylase,
has
emerged
as
pivotal
epigenetic
regulator
potential
regulate
through
wide
array
genes
intricately
metabolism,
homeostasis,
glutathione
biosynthesis,
redox
homeostasis.
This
review
provides
comprehensive
overview
specific
mechanisms
SIRT1
regulates
explores
its
therapeutic
value
in
context
multiple
disease
pathologies,
highlighting
significance
SIRT1-mediated
treatment
strategies.
Vaccines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 182 - 182
Published: Feb. 13, 2025
Histone
deacetylase
3
(HDAC3)
has
emerged
as
a
critical
epigenetic
regulator
in
tumor
progression
and
immune
modulation,
positioning
it
promising
target
for
enhancing
cancer
immunotherapy.
This
work
comprehensively
explores
HDAC3's
multifaceted
roles,
focusing
on
its
regulation
of
key
immune-modulatory
pathways
such
cGAS-STING,
ferroptosis,
the
Nrf2/HO-1
axis.
These
are
central
to
evasion,
antigen
presentation,
cell
activation.
Additionally,
distinct
effects
HDAC3
various
types-including
role
T
activation,
restoring
NK
cytotoxicity,
promoting
dendritic
maturation,
modulating
macrophage
polarization-are
thoroughly
examined.
findings
underscore
capacity
reshape
microenvironment,
converting
immunologically
"cold
tumors"
into
"hot
thereby
increasing
their
responsiveness
The
therapeutic
potential
inhibitors
is
highlighted,
both
standalone
agents
combination
with
checkpoint
inhibitors,
overcome
resistance
improve
treatment
efficacy.
Innovative
strategies,
development
selective
advanced
nano-delivery
systems,
integration
photodynamic
or
photothermal
therapies,
proposed
enhance
precision
minimize
toxicity.
By
addressing
challenges
toxicity,
patient
heterogeneity,
mechanisms,
this
study
provides
forward-looking
perspective
clinical
application
inhibitors.
It
highlights
significant
personalized
immunotherapy,
paving
way
more
effective
treatments
improved
outcomes
patients.
Cancer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 4, 2025
ABSTRACT
Crosstalk
between
cancer
cells
and
the
tumor
microenvironment
(TME)
is
a
key
event
in
malignant
progression
metastasis.
The
secretion
of
bioactive
substances
by
remodels
TME,
affecting
activities
its
components,
including
blood
vessels,
mesenchymal
cells,
immune
cells.
These
are
effectively
delivered
through
intracellular
trafficking
exocytosis
cytoplasmic
vesicles.
small
guanosine
triphosphatase
(GTPase)
RAB27
effectors,
synaptotagmin‐like
(SYTL)
family
proteins,
play
essential
roles
vesicle
trafficking.
Our
recent
research
demonstrates
upregulation
RAB27A/B
SYTL1/2
alveolar
soft
part
sarcoma
acute
myeloid
leukemia.
This
enhanced
promotes
angiogenesis
occupation
leukemia
bone
marrow
niche.
review
focuses
on
role
RAB27/SYTL
axis
various
types
associated
with
TME
modifications,
discussion
importance
as
therapeutic
target.
