MicroRNAs and RNA-Binding Protein-Based Regulation of Bone Metastasis from Hepatobiliary Cancers and Potential Therapeutic Strategies DOI Creative Commons
Sharmila Fagoonee, Ralf Weiskirchen

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1935 - 1935

Published: Nov. 21, 2024

Hepatobiliary cancers, such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the deadliest malignancies worldwide, leading to a significant number of cancer-related deaths. While bone metastases from these cancers rare, they highly aggressive linked poor prognosis. This review focuses on RNA-based molecular mechanisms that contribute metastasis hepatobiliary cancers. Specifically, role two key factors, microRNAs (miRNAs) RNA-binding proteins (RBPs), which have not been extensively studied in context HCC CCA, is discussed. These molecules often exhibit abnormal expression tumors, influencing cancer cell spread by disrupting homeostasis, thereby aiding tumor migration survival microenvironment. also discusses potential therapeutic strategies targeting pathways reduce improve patient outcomes. Further research crucial for developing effective miRNA- RBP-based diagnostic prognostic biomarkers treatments prevent

Language: Английский

MicroRNAs and RNA-Binding Protein-Based Regulation of Bone Metastasis from Hepatobiliary Cancers and Potential Therapeutic Strategies DOI Creative Commons
Sharmila Fagoonee, Ralf Weiskirchen

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1935 - 1935

Published: Nov. 21, 2024

Hepatobiliary cancers, such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the deadliest malignancies worldwide, leading to a significant number of cancer-related deaths. While bone metastases from these cancers rare, they highly aggressive linked poor prognosis. This review focuses on RNA-based molecular mechanisms that contribute metastasis hepatobiliary cancers. Specifically, role two key factors, microRNAs (miRNAs) RNA-binding proteins (RBPs), which have not been extensively studied in context HCC CCA, is discussed. These molecules often exhibit abnormal expression tumors, influencing cancer cell spread by disrupting homeostasis, thereby aiding tumor migration survival microenvironment. also discusses potential therapeutic strategies targeting pathways reduce improve patient outcomes. Further research crucial for developing effective miRNA- RBP-based diagnostic prognostic biomarkers treatments prevent

Language: Английский

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