Unveiling ferroptosis: a new frontier in skin disease research DOI Creative Commons
Ke Wang,

Yumeng Lin,

Dan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

Female sex hormones exacerbate retinal neurodegeneration DOI Creative Commons
Ashley A. Rowe,

Mauricio J. Velasquez,

Jacob W. Aumeier

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(15)

Published: April 11, 2025

Neurodegenerative disorders such as Alzheimer’s disease and macular degeneration represent major sources of human suffering, yet factors influencing severity remain poorly understood. Sex has been implicated one modifying factor. Here, we show that female sex is a risk factor for worsened outcomes in model retinal this susceptibility caused by the presence female-specific hormones. The adverse effect hormones was specific to diseased neurons, depletion these ameliorated phenotypic effect, while reintroduction rates females. Transcriptional analysis retinas showed significant differences between genes involved pyroptosis, inflammatory responses, endoplasmic reticulum stress–induced apoptosis males females with degeneration. These findings provide crucial insights into pathogenesis neurodegenerative diseases how can affect severity. have far-reaching implications clinical trial design use hormonal therapy certain disorders.

Language: Английский

Citations

0
Computational recognition of regulator genes and signature for ferroptosis with implications on immunological properties and clinical management of atopic dermatitis DOI Creative Commons
Lei Xu, Wenjuan Guo,

Huirong Hao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 6, 2024

Atopic dermatitis (AD) is a common chronic of autoimmune origin that considerably affects the quality life patients. Ferroptosis, newly regulated form cell death, essential for inflammation-related damage-associated molecular patterns (DAMPs). In this study, we aimed to identify ferroptosis regulators relevant AD pathogenesis and reveal mechanisms by which regulates AD.

Language: Английский

Citations

3
Salidroside alleviates ferroptosis in FAC-induced Age-related macular degeneration models by activating Nrf2/SLC7A11/GPX4 axis DOI
Meijiang Zhu, Jing Yu

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113041 - 113041

Published: Sept. 12, 2024

Language: Английский

Citations

3
Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies DOI Creative Commons
Chao Ma, Haoyu Li, Shuwen Lu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Thyroid-associated ophthalmopathy (TAO) is an inflammatory orbital disease associated with autoimmune thyroid disorders. Owing to the ambiguous nature of pathogenesis, contemporary pharmacological treatment strategies predominantly involve use glucocorticoids and immunosuppressants. However, adverse effects these agents in clinical practice necessitate further investigation into disease's pathogenesis identification novel therapeutic targets interventions. Recent studies suggest that ferroptosis, a form regulated cell death, may play role TAO pathogenesis. This review aims explore involvement ferroptosis evaluate its potential as target. Key topics include epidemiology, manifestations, pathophysiology TAO, along molecular mechanisms ferroptosis. Evidence supporting implications targeting this pathway are also discussed, alongside challenges future directions emerging research area.

Language: Английский

Citations

1
Unveiling ferroptosis: a new frontier in skin disease research DOI Creative Commons
Ke Wang,

Yumeng Lin,

Dan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

Citations

0