Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—Aetiology and Potential Treatments DOI Open Access
Amolak S. Bansal, Katharine A. Seton, J.C. Brooks

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1896 - 1896

Published: Feb. 22, 2025

Systemic infection and inflammation impair mental function through a combination of altered attention cognition. Here, we comprehensively review the relevant literature report personal clinical observations to discuss relationship between infection, peripheral inflammation, cerebral cognitive dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Cognitive ME/CFS could result from low-grade persistent associated raised pro-inflammatory cytokines. This may be caused by both infectious non-infectious stimuli lead regional blood flow accompanied disturbed neuronal function. Immune dysregulation that manifests as subtle immunodeficiency or autoimmunity targeting one more receptors also contributing factor. Efforts reduce systemic viral reactivation improve mitochondrial energy generation have potential this highly disabling condition.

Language: Английский

Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—Aetiology and Potential Treatments DOI Open Access
Amolak S. Bansal, Katharine A. Seton, J.C. Brooks

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1896 - 1896

Published: Feb. 22, 2025

Systemic infection and inflammation impair mental function through a combination of altered attention cognition. Here, we comprehensively review the relevant literature report personal clinical observations to discuss relationship between infection, peripheral inflammation, cerebral cognitive dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Cognitive ME/CFS could result from low-grade persistent associated raised pro-inflammatory cytokines. This may be caused by both infectious non-infectious stimuli lead regional blood flow accompanied disturbed neuronal function. Immune dysregulation that manifests as subtle immunodeficiency or autoimmunity targeting one more receptors also contributing factor. Efforts reduce systemic viral reactivation improve mitochondrial energy generation have potential this highly disabling condition.

Language: Английский

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