Investigating the Role of B Cell Receptors in Pathogen Recognition and Immune Response Activation: Implications for Infection Control and Therapeutic Development DOI

Selin Özalp

Next frontier., Journal Year: 2024, Volume and Issue: 8(1), P. 169 - 169

Published: Nov. 25, 2024

B cell receptors (BCRs) are critical components of the adaptive immune system, enabling precise pathogen recognition and activation responses. This research examines molecular genetic mechanisms underlying BCR function, focusing on their role in detecting, binding, neutralizing infectious agents. By exploring antigen-BCR interactions, we aim to elucidate how BCRs achieve remarkable specificity affinity, ultimately shaping strength duration Through advanced immunological assays, flow cytometry, bioinformatics, this study characterizes diversity expression across various models. Genetic processes such as somatic hypermutation clonal selection analyzed understand repertoires adapt rapidly evolving pathogens. Predictive models developed using machine learning identify biomarkers within pathways, providing insights into acute infections, chronic diseases, autoimmune conditions. The findings highlight variations function that influence resilience susceptibility infections. These inform vaccine development, antibody engineering, therapeutic strategies targeting pathways. underscores potential targets, paving way for innovative approaches infection control modulation, advancing precision medicine immunity research.

Language: Английский

Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy DOI Creative Commons
Yang Xu, YangQuan Chen,

Jia‐xin Xing

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on biological functions associated with NDs, emphasizing role in enhancing neural plasticity, reducing inflammation, and bolstering cognitive performance. We discussed molecular underpinnings effects EE, including modulation key signaling pathways such extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), AMPK/SIRT1, which were implicated neuroprotection synaptic plasticity. Additionally, we scrutinized influence epigenetic modifications autophagy, processes pivotal ND pathogenesis. Animal models, encompassing both rodents larger animals, offer insights into disease-modifying underscoring complementary approach pharmacological interventions. In summary, emerges promising strategy augment function decelerate progression NDs.

Language: Английский

Citations

1
Investigating the Role of B Cell Receptors in Pathogen Recognition and Immune Response Activation: Implications for Infection Control and Therapeutic Development DOI

Selin Özalp

Next frontier., Journal Year: 2024, Volume and Issue: 8(1), P. 169 - 169

Published: Nov. 25, 2024

B cell receptors (BCRs) are critical components of the adaptive immune system, enabling precise pathogen recognition and activation responses. This research examines molecular genetic mechanisms underlying BCR function, focusing on their role in detecting, binding, neutralizing infectious agents. By exploring antigen-BCR interactions, we aim to elucidate how BCRs achieve remarkable specificity affinity, ultimately shaping strength duration Through advanced immunological assays, flow cytometry, bioinformatics, this study characterizes diversity expression across various models. Genetic processes such as somatic hypermutation clonal selection analyzed understand repertoires adapt rapidly evolving pathogens. Predictive models developed using machine learning identify biomarkers within pathways, providing insights into acute infections, chronic diseases, autoimmune conditions. The findings highlight variations function that influence resilience susceptibility infections. These inform vaccine development, antibody engineering, therapeutic strategies targeting pathways. underscores potential targets, paving way for innovative approaches infection control modulation, advancing precision medicine immunity research.

Language: Английский

Citations

0