Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in metabolic dysfunction associated steatotic liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 29, 2025

Language: Английский

Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

In recent years, the prevalence of chronic liver diseases, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), has increased significantly. This upward trend is largely associated with lifestyle-related factors such as unhealthy dietary habits, physical inactivity, and various environmental influences. Among key elements contributing to pathogenesis MASLD, integrity intestinal epithelial barrier emerges a critical determinant, given its central role in maintaining immune homeostasis along gut-liver axis. Disruption this barrier, often driven by excessive consumption saturated fats refined carbohydrates combination low fiber intake, can lead microbial dysbiosis. imbalance gut microbiota triggers dysregulation promotes systemic inflammation, thereby exacerbating hepatic injury. review discusses contribution dysfunction development progression particular focus on how permeability may initiate sustain inflammation. Additionally, influence integrity, responses, inflammatory cascade addressed. A better understanding complex interplay between impairment, modulation, pathology offer valuable insights into MASLD pathophysiology contribute more targeted therapeutic strategies.

Language: Английский

Advances in understanding the role of interleukins in pulmonary fibrosis (Review)

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 29(2)

Published: Nov. 28, 2024

Pulmonary fibrosis (PF) is a progressive, irreversible disease characterized by heterogeneous interstitial lung tissue damage. It originates from persistent or repeated epithelial injury and leads to the activation differentiation of fibroblasts into myofibroblasts. Interleukins (ILs) are group lymphokines crucial for immunomodulation that implicated in pathogenesis PF. However, different types ILs exert disparate effects on In present review, based effect PF, classified three categories: i) Promotors PF; ii) inhibitors iii) those dual Several can promote PF provoking inflammation, initiating proliferation transdifferentiation cells, exacerbating injury, while other inhibit through suppressing expression inflammatory factors, modulating Th1/Th2 balance autophagy. The review summarizes association focusing roles mechanisms underlying

Language: Английский