Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 270 - 270
Published: Feb. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Language: Английский
The Intersection of the Upper Gastrointestinal Microbiome and Oesophageal Cancer: A Review of Pathways and Therapeutic Insights
European Medical Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
The
upper
gastrointestinal
microbiome,
a
complex
ecosystem
of
microorganisms
that
have
historically
been
difficult
to
identify,
may
play
pivotal
role
in
the
development
oesophageal
cancer
and
postoperative
outcomes.
Dysbiosis,
characterised
by
imbalances
microbial
composition,
is
believed
drive
tumorigenesis
various
cancers
through
mechanisms
such
as
chronic
inflammation,
immune
suppression,
epithelial
barrier
dysfunction.
Additionally,
dysbiosis
contribute
complications,
including
anastomotic
leaks
infections
following
surgery.
Most
research
date
has
focused
on
colorectal
cancer,
demonstrating
these
relationships.
Pathogenic
bacteria
exacerbate
dysregulation
processes
pro-inflammatory
cytokine
release,
evasion,
biofilm
formation.
Therapeutic
strategies
targeting
microbiome
hold
promise
for
restoring
balance,
reducing
systemic
improving
surgical
This
review
synthesises
current
evidence
microbiome’s
pathogenesis
outcomes,
highlighting
opportunities
therapeutic
interventions
potential
integrating
into
management
protocols.
Language: Английский
Role of gut microbiome in suppression of cancers
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: April 20, 2025
The
pathogenesis
of
cancer
is
closely
related
to
the
disruption
homeostasis
in
human
body.
gut
microbiome
plays
crucial
roles
maintaining
its
host
throughout
lifespan.
In
recent
years,
a
large
number
studies
have
shown
that
dysbiosis
involved
entire
process
initiation,
development,
and
prognosis
by
influencing
immune
system
metabolism.
Some
specific
intestinal
bacteria
promote
occurrence
development
cancers
under
certain
conditions.
Conversely,
some
other
suppress
oncogenesis
progression
cancers,
including
inhibiting
delaying
boosting
therapeutic
effect
on
cancers.
promoting
effects
been
comprehensively
discussed
previous
review.
This
article
will
review
latest
advances
mechanisms
suppression,
providing
new
perspective
for
developing
strategies
prevention
treatment.
Language: Английский