Role of gut microbiome in suppression of cancers DOI Creative Commons
Yao Xu, Zhaoyu Gao, Jiaying Liu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 20, 2025

The pathogenesis of cancer is closely related to the disruption homeostasis in human body. gut microbiome plays crucial roles maintaining its host throughout lifespan. In recent years, a large number studies have shown that dysbiosis involved entire process initiation, development, and prognosis by influencing immune system metabolism. Some specific intestinal bacteria promote occurrence development cancers under certain conditions. Conversely, some other suppress oncogenesis progression cancers, including inhibiting delaying boosting therapeutic effect on cancers. promoting effects been comprehensively discussed previous review. This article will review latest advances mechanisms suppression, providing new perspective for developing strategies prevention treatment.

Language: Английский

Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

Citations

5

The Intersection of the Upper Gastrointestinal Microbiome and Oesophageal Cancer: A Review of Pathways and Therapeutic Insights DOI Creative Commons
Jenny Bui, Kevin R. Ward, Rishindra M. Reddy

et al.

European Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

The upper gastrointestinal microbiome, a complex ecosystem of microorganisms that have historically been difficult to identify, may play pivotal role in the development oesophageal cancer and postoperative outcomes. Dysbiosis, characterised by imbalances microbial composition, is believed drive tumorigenesis various cancers through mechanisms such as chronic inflammation, immune suppression, epithelial barrier dysfunction. Additionally, dysbiosis contribute complications, including anastomotic leaks infections following surgery. Most research date has focused on colorectal cancer, demonstrating these relationships. Pathogenic bacteria exacerbate dysregulation processes pro-inflammatory cytokine release, evasion, biofilm formation. Therapeutic strategies targeting microbiome hold promise for restoring balance, reducing systemic improving surgical This review synthesises current evidence microbiome’s pathogenesis outcomes, highlighting opportunities therapeutic interventions potential integrating into management protocols.

Language: Английский

Citations

0

Role of gut microbiome in suppression of cancers DOI Creative Commons
Yao Xu, Zhaoyu Gao, Jiaying Liu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 20, 2025

The pathogenesis of cancer is closely related to the disruption homeostasis in human body. gut microbiome plays crucial roles maintaining its host throughout lifespan. In recent years, a large number studies have shown that dysbiosis involved entire process initiation, development, and prognosis by influencing immune system metabolism. Some specific intestinal bacteria promote occurrence development cancers under certain conditions. Conversely, some other suppress oncogenesis progression cancers, including inhibiting delaying boosting therapeutic effect on cancers. promoting effects been comprehensively discussed previous review. This article will review latest advances mechanisms suppression, providing new perspective for developing strategies prevention treatment.

Language: Английский

Citations

0