Cutaneous Manifestations of Systemic Lupus Erythematosus and Their Correlation With Cardiac Involvement DOI Open Access

Romasa Zeb,

Daniela Valentina Combariza Chinome,

Mario Peña Chacón

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread immune dysregulation that affects multiple organ systems, including the skin and cardiovascular system. The crosstalk between different cell death pathways-such as apoptosis, necroptosis, neutrophil extracellular trap (NETosis), plays pivotal role in pathogenesis of SLE, influencing both cutaneous cardiac manifestations. Cutaneous (CLE) one most common early signs affecting up to 80% patients. CLE presents several forms, acute, subacute, lesions, each with varying degrees association systemic disease. Cardiac involvement, although often underrecognized, significantly contributes morbidity mortality SLE patients, manifesting pericarditis, myocarditis, valvular disease, accelerated atherosclerosis. Emerging research suggests these manifestations may be connected through shared mechanisms, complex deposition, endothelial dysfunction, inflammation driven cytokines such Interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α). severity involvement correlate an increased risk events, underscoring importance diagnosis multidisciplinary approach treatment. This review explores among pathways examines how contribute Furthermore, it highlights clinical implications this discusses potential therapeutic strategies aimed at modulating improve patient outcomes. Challenges gaps current are also addressed, emphasizing need for further investigation into interactions.

Language: Английский

Predictors of Mortality in Acute Myocardial Infarction Patients With Systemic Lupus Erythematosus DOI Open Access

Etuk Aniekeme,

Bruno de Souza Gonçalves, Komal Sodhi

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Introduction Acute myocardial infarction (AMI) remains a leading cause of mortality globally, with systemic lupus erythematosus (SLE) posing additional risks for adverse outcomes. Methods This retrospective cohort study utilized data from the Healthcare Cost and Utilization Project National Inpatient Sample 2016 to 2020 investigate predictors among hospitalized AMI patients, stratified by SLE status. Results A total 81,935 patients were included, variables analyzed using multivariate logistic regression. Among being female, aged ≥65 years, having prolonged hospital stay >5 days associated higher mortality. Elective admissions protective while non-Hispanic Black showed reduced odds compared their White counterparts. non-SLE increased included stays. Private insurance coverage was lower in this group. Conclusion These findings highlight critical patient- hospital-related factors influencing without SLE. Targeted strategies focusing on early recognition, effective interventions, reducing healthcare disparities are essential improve outcomes population.

Language: Английский

Citations

1
Oleanolic Acid Derivative OA17 Inhibits Trophoblast Apoptosis by Suppressing HIF-1α Nuclear Translocation in SLE-Associated Adverse Pregnancy Outcomes DOI

Mengqi Zhou,

Lin Jin,

Pan Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156641 - 156641

Published: April 1, 2025

Language: Английский

Citations

0
Cutaneous Manifestations of Systemic Lupus Erythematosus and Their Correlation With Cardiac Involvement DOI Open Access

Romasa Zeb,

Daniela Valentina Combariza Chinome,

Mario Peña Chacón

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread immune dysregulation that affects multiple organ systems, including the skin and cardiovascular system. The crosstalk between different cell death pathways-such as apoptosis, necroptosis, neutrophil extracellular trap (NETosis), plays pivotal role in pathogenesis of SLE, influencing both cutaneous cardiac manifestations. Cutaneous (CLE) one most common early signs affecting up to 80% patients. CLE presents several forms, acute, subacute, lesions, each with varying degrees association systemic disease. Cardiac involvement, although often underrecognized, significantly contributes morbidity mortality SLE patients, manifesting pericarditis, myocarditis, valvular disease, accelerated atherosclerosis. Emerging research suggests these manifestations may be connected through shared mechanisms, complex deposition, endothelial dysfunction, inflammation driven cytokines such Interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α). severity involvement correlate an increased risk events, underscoring importance diagnosis multidisciplinary approach treatment. This review explores among pathways examines how contribute Furthermore, it highlights clinical implications this discusses potential therapeutic strategies aimed at modulating improve patient outcomes. Challenges gaps current are also addressed, emphasizing need for further investigation into interactions.

Language: Английский

Citations

0