The role of complement in tumor immune tolerance and drug resistance: a double-edged sword

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

The domain of cancer treatment has persistently been confronted with significant challenges, including those associated recurrence and drug resistance. complement system, which serves as the foundation innate immune exhibits intricate nuanced dual characteristics in evolution tumors. On one hand, system capacity to directly inhibit cell proliferation via specific pathways, thereby exerting a beneficial anti-tumor effect. Conversely, can also facilitate establishment an escape barrier for cells through non-complement-mediated mechanisms, protecting them from eradication. Concurrently, be implicated emergence resistance multitude complex or indirectly reducing efficacy therapeutic interventions facilitating progression cancer. This paper analyses role tumors reviews recent research advances mechanisms tumor tolerance

Language: Английский

Molecule Formats of B-Cell Targeting Biologics: Applications in Autoimmune Disease Treatment and Impacts on Manufacturability

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 495 - 495

Published: April 8, 2025

The targeting of B-lymphocyte cells has emerged as one the most pivotal strategies in management autoimmune diseases. This review provides an overview protein therapeutics illustrating their direct and indirect effects on B-cells using different molecule formats. design format these molecules influence mode action affect manufacturing strategies. Manufacturability should be assessed at early stage continuously through collaboration between discovery development teams. Scalability evaluations encompass not only process facility compatibility but also cell line development. Examples format-specific manufacturability biologics are reviewed to offer general insights into enhancing productivity quality a cost-effective manner.

Language: Английский

Innate immune cells in acute and chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский