Maternal IgE Influence on Fetal and Infant Health DOI Creative Commons
Jozef Balla,

Abhay P. S. Rathore,

Ashley L. St. John

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: April 25, 2025

ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, other insults to barrier tissues exposed environment. IgE MCs act inflammation amplifiers response adjuvants. Thus, production memory formation are greatly constrained require specific licensing. Failure of regulation gives rise allergic disease, one top causes chronic illness. Increasing evidence suggests allergy development often starts early in life, including prenatally, maternal influence being central shaping offspring's system. Although exists before birth, an endogenous source IgE‐producing B has not been identified. This review discusses mechanisms transfer into offspring, its interactions offspring antigen‐presenting cells, consequences allergen sensitization development. We discuss multifaceted effects pre‐existing IgG, IgE, their glycosylation on functionality progeny. Understanding predisposing life may allow targeting existing therapeutics guide new ones.

Language: Английский

Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis DOI Creative Commons

Fangyi Ruan,

Yinan Wang, Ying Xiang

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 27, 2025

Epidemiological evidence indicates that preeclampsia (PE) is associated with comorbidities such as periodontitis (PD). However, the underlying mechanism remains unclear. To enhance our understanding of their co-pathogenesis, this research investigated shared biomarkers and pathological mechanisms. We systematically retrieved transcriptomic datasets from Gene Expression Omnibus database. These encompass a comparative analysis periodontium without PD placenta PE. Differentially Expressed Genes Analysis Weighted Go-expression Network (WGCNA) were used to identify key crosstalk genes in patients The functional characterisation these was performed using enrichment analysis. Protein–protein interaction networks machine learning methods leveraged hub genes. XG-Boost algorithm applied construct diagnostic models gain insight into disease aetiology. identified validated by single-cell RNA sequencing ensure robustness biological relevance. A total 55 identified, which primarily enriched immune-related pathways limma WGCNA. Among them, twenty-four protein–protein methods. model constructed outperformed other two (area under receiver operating characteristic curve [ROC] = 0.7786 0.7454 for PE PD, respectively). Pathways involving mapped Kyoto Encyclopedia Genomes In addition, showed expression BIN2, LYN, PIK3AP1, NEDD9 neutrophils significantly downregulated, LYN fibroblasts endothelial cells consistently upregulated. Shared immunologic characterised between NEDD9, suggesting pathogenesis could pave way development effective diagnostic, treatment, management strategies.

Language: Английский

Citations

2
Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure DOI Open Access
Jenny Valentina Garmendia, Claudia Valentina De Sanctis, Marián Hajdúch

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1295 - 1295

Published: Feb. 3, 2025

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive losses before 24 weeks gestation. It affects 3-5% women who are attempting to conceive. RPL can stem from a variety causes and frequently associated with psychological distress diminished quality life. By contrast, recurrent implantation failure (RIF) refers inability achieve successful after three high-quality embryo transfers at least instances egg donation. RIF shares several causative factors RPL. The immunological underpinnings these conditions involve alterations in uterine NK cells, reductions M2 macrophages myeloid-derived suppressor an increased Th1/Th2 ratio, decreased Treg/Th17 presence shared ≥3 HLA alleles between partners, autoimmune disorders. Various therapeutic approaches have been employed address concerns, achieving varying degrees success, although some therapies remain contentious within medical community. This review intends explore implicated analyze treatments for conditions, which may include steroids, intravenous immunoglobulins, calcineurin inhibitors, anti-TNF antibodies, intralipid infusions, granulocyte colony-stimulating factor, lymphocyte immunotherapy.

Language: Английский

Citations

0
Decoding immune tolerance in infertility: Exploring immune pathways and non-coding RNAs as pioneering biomarkers and therapeutic targets DOI
Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hjazi

et al.

Human Immunology, Journal Year: 2025, Volume and Issue: 86(3), P. 111264 - 111264

Published: Feb. 20, 2025

Language: Английский

Citations

0
Maternal IgE Influence on Fetal and Infant Health DOI Creative Commons
Jozef Balla,

Abhay P. S. Rathore,

Ashley L. St. John

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: April 25, 2025

ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, other insults to barrier tissues exposed environment. IgE MCs act inflammation amplifiers response adjuvants. Thus, production memory formation are greatly constrained require specific licensing. Failure of regulation gives rise allergic disease, one top causes chronic illness. Increasing evidence suggests allergy development often starts early in life, including prenatally, maternal influence being central shaping offspring's system. Although exists before birth, an endogenous source IgE‐producing B has not been identified. This review discusses mechanisms transfer into offspring, its interactions offspring antigen‐presenting cells, consequences allergen sensitization development. We discuss multifaceted effects pre‐existing IgG, IgE, their glycosylation on functionality progeny. Understanding predisposing life may allow targeting existing therapeutics guide new ones.

Language: Английский

Citations

0