Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: March 27, 2025
Pulmonary disease is a continuously growing field. Recent research focus on basic and clinical advances in interstitial lung (ILD) including idiopathic pulmonary fibrosis (IPF) IPF genoma,chronic obstructive (COPD), epigenetic, hypertension (PH), sarcoidosis, eosinophilic pneumonia.Autophagy plays vital role the maintenance of homeostasis recent studies explored connection between autophagy development different diseases. Autophagy seems to play protective pathogenetic COPD progression. Conflicting results have been obtained played by PH asthma (1).Epigenetic mechanisms include post-translational methylation acetylation histone proteins DNA as well modulation miRNA production. Up-or down-regulation various genes demonstrated COPD, variety epigenetic alterations, modification histone, DNA, non-coding RNA reported IPF, methylation, modifications, noncoding shown PAH (2). Additionally, may improve ILD early diagnosis treatment avoiding several biases especially most common with poor survival rate.A current major problem search an accurate vasodilator patients suffering from (PH) associated IPF. The latter when combined regrouped Group 3 ERS/ESC Guideline (3). Nathan et al (4) suggested treprostenil therapy. However, further trials are needed establish efficacy this because study appear still inconclusive (5).Multiplexed immunolabeling situ sequencing transcriptomic analysis tissue sections got new insights into immunopathogenesis sarcoidosis granulomas. Sarcoidosis lesions contain T-cell infiltrates which surround granuloma core B-cell clusters morphologically molecularly suggestive tertiary lymphoid structures (6). New perspectives present identifying fatigue extremely significant symptom distinguishing other chronic diseases (7).PET) performed suspected cardiac sarcoidosis. data suggest that association [18F] FDG PET late gadolinium tracer enhancement magnetic resonance help differentiating causes myocardial inflammation (8).Acute rare disease. Pathological findings high-resolution computed tomography (HRCT) imaging patterns diagnostic accuracy facilitate differential (9).An international group radiologists pulmonologists (10) proposed deep learning algorithm, based ATS/ERS/JRS/ALAT guidelines criteria (SOFIA), classifying HRCT for diagnosis. included 203 concluded artificial intelligence (AI) improves evaluation Algorithms features, radiological specific autoantibodies developed management connective like systemic sclerosis, rheumatoid arthritis, polymyositis/dermatomyositis (11).Patients affected sclerosis frequently develop (SSc-ILD). Survival SSc-ILD significantly better than IPF-usual pneumonia (UIP) negatively York Heart Association (NYHA) class arterial pressure value (12). Some limitations incidence prevalence regional Registries. In fact only recently Asian Pacific Registry published allowing comparison European Registries (13). progression remain uncertain at number exacerbation/yr. cancer same patient has found. These non small cell (NSCL), their about 10% very prognosis. Of note Uhlenbruch (14) 48% -NSCLC autopsy. Last but not least, great developments made genoma detection well-established variants within TERT RTEL1 that,in environmental factors, largely contribute risk (15).To conclude annual review summarizes interesting all although large multicenter required next future our knowledge these topics.
Language: Английский