Monitoring Immune Responses to Vaccination: A Focus on Single-Cell Analysis and Associated Challenges DOI Creative Commons

L. C. Montgomery,

Anis Larbi

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 420 - 420

Published: April 16, 2025

Monitoring the immune response to vaccination encompasses both significant challenges and promising opportunities for scientific advancement. The primary challenge lies in inherent complexity interindividual variability of responses, influenced by factors including age, genetic background, prior immunological history. This necessitates development sophisticated, highly sensitive assays capable accurately quantifying parameters such as antibody titers, T-cell cytokine profiles. Furthermore, temporal dynamics require comprehensive longitudinal studies elucidate durability quality vaccine-induced immunity. Challenges this magnitude pave way research advancements diagnostic methodologies. Cutting-edge monitoring techniques, high-throughput sequencing advanced flow cytometry, enable deeper insights into mechanistic underpinnings vaccine efficacy contribute iterative design more effective vaccines. Additionally, integration analytical tools holds potential predict responses tailor personalized strategies. will be addressed review provide insight enhancing public health outcomes fortifying preparedness against future infectious disease threats.

Language: Английский

Monitoring Immune Responses to Vaccination: A Focus on Single-Cell Analysis and Associated Challenges DOI Creative Commons

L. C. Montgomery,

Anis Larbi

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 420 - 420

Published: April 16, 2025

Monitoring the immune response to vaccination encompasses both significant challenges and promising opportunities for scientific advancement. The primary challenge lies in inherent complexity interindividual variability of responses, influenced by factors including age, genetic background, prior immunological history. This necessitates development sophisticated, highly sensitive assays capable accurately quantifying parameters such as antibody titers, T-cell cytokine profiles. Furthermore, temporal dynamics require comprehensive longitudinal studies elucidate durability quality vaccine-induced immunity. Challenges this magnitude pave way research advancements diagnostic methodologies. Cutting-edge monitoring techniques, high-throughput sequencing advanced flow cytometry, enable deeper insights into mechanistic underpinnings vaccine efficacy contribute iterative design more effective vaccines. Additionally, integration analytical tools holds potential predict responses tailor personalized strategies. will be addressed review provide insight enhancing public health outcomes fortifying preparedness against future infectious disease threats.

Language: Английский

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