Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibetan sheep DOI Creative Commons

Jiacheng Gan,

Qiurong Ji, Quyangangmao Su

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 11, 2024

Introduction The effects of resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) on phenotype, immunity, digestive enzyme activity short-chain fatty acids (SCFAs) contents in ileum Tibetan sheep were investigated. Methods A total 120 two-month-old (15.5 ± 0.14 kg) randomly allocated to 4 treatments: control group (basal diet), RES diet +1.5 g RES/d), HMB +1.25 HMB/d), RES-HMB RES/d + 1.25 HMB/d). Results indicated that dietary (or) supplementation significantly improved the phenotype (mucosal thickness villus width), SCFAs concentrations, enzymes (lipase, cellulase, α -amylase) ( p < 0.05). relative abundance Brevibacillus , Clostridium sensu stricto 3 Eubacterium hallii increased, while Ruminococcus Mogibacterium decreased 0.05) group. metabolic profiling an increase differential metabolites (DMs) including L-arginine, butanoic acid, D-mannose, retinol increased Discussion In summary, our results suggested concentration by up-regulating microbial community ) metabolism (L-arginine, retinol), thus contributing ileal morphology activity. These findings may provides a novel reference for nutritional regulation improve production sheep.

Language: Английский

Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sjögren’s syndrome DOI Creative Commons
Fengtao Pang, Quan Jiang, Xiaopo Tang

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Language: Английский

Citations

0
Roughage Sources During Late Gestation and Lactation Alter Metabolism, Immune Function and Rumen Microbiota in Ewes and Their Offsprings DOI Creative Commons
Haidong Du, Kenan Li,

Wenliang Guo

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 394 - 394

Published: Feb. 11, 2025

Maternal metabolic intensity significantly increases during late gestation and lactation, placing significant stress on cells tissues. This heightened demand can lead to inflammatory responses disorders, adversely affecting the health of both mother her offspring. Diet plays a key role in modulating host by influencing gastrointestinal microbiome. study examined impact two roughage sources, corn straw (CS), alfalfa hay (AH), ewes their offspring with focus metabolism, immunity, Thirty-six multiparous Inner Mongolia cashmere goats, approximately 60 days pregnant, were assigned CS AH groups. Samples collected from day 140 (G140) 28 lactation (L28) for analysis. The results showed that fed had reduced body weight loss (p < 0.05), increased serum factors levels 0.05). Additionally, group exhibited response compared those group, as evidenced decrease TNF-α LPS notable increase IL-10 rumen microbiomes groups stark differences, specific microbial markers identified at G140 L28. Correlation analysis revealed associations between microbiome, volatile fatty acids, cytokines, markers. lambs demonstrated immune status composition influenced community structure ewe. Moreover, immune-related components transmitted lambs, further shaping development microbiota. Overall, different sources minimal growth performance given diets iso-nitrogen iso-energetic. However, improvements function overall them lambs.

Language: Английский

Citations

0
Butyrate improves testicular spermatogenic dysfunction induced by a high-fat diet DOI Open Access

Xiangen Liu,

Yujuan Qi, Τao Zhu

et al.

Translational Andrology and Urology, Journal Year: 2025, Volume and Issue: 14(3), P. 627 - 636

Published: March 1, 2025

Obesity is closely associated with low male fertility and decreased sperm quality. accompanied by an ecological imbalance in the gut microbiota, so it of great significance to intervene infertility caused obesity from perspective microbiota metabolites. This study aimed evaluate efficacy butyrate ameliorating obesity-induced spermatogenic dysfunction explore potential molecular mechanisms. explored role recovering dysfunctions spermatogenesis inducing obese model mice a high-fat diet (HFD). The effects HFD on testicular function were based metabolomics. results showed that decrease count, motility, increase malformation rate mice. After adding HFD, various indicators significantly improved. Through analysis metabolomics data mouse testes, this found altered metabolic status involving multiple pathways. However, after butyrate, some characteristics tended be similar those normal mice, steroid biosynthesis primary bile acid pathways clarified effect improving quality, providing experimental evidence for treatment abnormal butyrate.

Language: Английский

Citations

0
Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibetan sheep DOI Creative Commons

Jiacheng Gan,

Qiurong Ji, Quyangangmao Su

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 11, 2024

Introduction The effects of resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) on phenotype, immunity, digestive enzyme activity short-chain fatty acids (SCFAs) contents in ileum Tibetan sheep were investigated. Methods A total 120 two-month-old (15.5 ± 0.14 kg) randomly allocated to 4 treatments: control group (basal diet), RES diet +1.5 g RES/d), HMB +1.25 HMB/d), RES-HMB RES/d + 1.25 HMB/d). Results indicated that dietary (or) supplementation significantly improved the phenotype (mucosal thickness villus width), SCFAs concentrations, enzymes (lipase, cellulase, α -amylase) ( p &lt; 0.05). relative abundance Brevibacillus , Clostridium sensu stricto 3 Eubacterium hallii increased, while Ruminococcus Mogibacterium decreased 0.05) group. metabolic profiling an increase differential metabolites (DMs) including L-arginine, butanoic acid, D-mannose, retinol increased Discussion In summary, our results suggested concentration by up-regulating microbial community ) metabolism (L-arginine, retinol), thus contributing ileal morphology activity. These findings may provides a novel reference for nutritional regulation improve production sheep.

Language: Английский

Citations

0