Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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The Role of the Gut Microbiota in Modulating Signaling Pathways and Oxidative Stress in Glioma Therapies

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 719 - 719

Published: Feb. 20, 2025

Tumors of the central nervous system (CNS), especially gliomas, pose a significant clinical challenge due to their aggressive nature and limited therapeutic options. Emerging research highlights critical role gut microbiota in regulating CNS health disease. The composition is essential for maintaining homeostasis, as it modulates immune responses, oxidative status, neuroinflammation. microbiota–gut–brain axis, bidirectional communication network, plays pivotal cancer disease treatment, exerting its influence through neural, endocrine, immunological, metabolic pathways. Recent studies suggest that influences solidification tumor microenvironment dysbiosis may promote glioma development by modulating systemic inflammation stress, which contributes tumorigenesis progression. This review interrogates impact on glioma, focusing pathways such NF-κB, MAPK, PI3K/Akt/mTOR, Kynurenine/AhR drive proliferation, evasion, therapy resistance. Furthermore, we explore emerging strategies, including probiotics microbiota-based interventions, show potential these enhancing immunotherapies checkpoint inhibitors. By multifaceted interactions between microbiota, tumors, this microbiota-targeted therapies manipulation complement enhance current treatments.

Language: Английский

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Microbiota-derived extracellular vesicles: current knowledge, gaps, and challenges in precision nutrition

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

The gut microbiota has co-evolved with its host, profoundly shaping the development and functioning of immune system. This co-evolution led to a dynamic relationship where microbial metabolites molecular signals influence maturation, tolerance, defense mechanisms, highlighting essential role in maintaining host health. Recently, bacterial extracellular vesicles (BEVs), membrane nanoparticles produced by bacteria, have emerged as important players balance potent modulators. These reflect characteristics contain nucleic acids, proteins, lipids, metabolites. They can regulate processes are involved neurological metabolic diseases due their ability distribute both locally systemically, affecting responses at levels. review provides comprehensive overview functional profile BEVs, detailing how nutrition influences production function these vesicles, antibiotics disrupt or alter composition, factors collectively impact immunity disease development. It also highlights potential BEVs precision nutritional strategies through dietary modulation, such incorporating prebiotic fibers enhance beneficial BEV production, reducing intake processed foods that may promote harmful tailoring probiotic interventions specific communities vesicular outputs.

Language: Английский

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The oncobiome; what, so what, now what?

Microbiome Research Reports, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 27, 2025

Microbial communities inhabiting various body sites play critical roles in the initiation, progression, and treatment of cancer. The gut microbiota, a highly diverse microbial ecosystem, interacts with immune cells to modulate inflammation surveillance, influencing cancer risk therapeutic outcomes. Local tissue microbiota may impact transition from premalignant states malignancy. Characterization intratumoral increasingly reveals distinct microbiomes that influence tumor growth, responses, efficacy. Various bacteria species have been reported therapies through mechanisms such as altering drug metabolism shaping microenvironment (TME). For instance, or bacterial enzymatic activity can convert prodrugs into active forms, enhancing effects or, conversely, inactivating small-molecule chemotherapeutics. Specific also linked improved responses immunotherapy, underscoring microbiome’s role Furthermore, unique signatures patients, compared healthy individuals, demonstrate diagnostic potential microbiota. Beyond gut, tumor-associated local affect therapy by inflammation, resistance. This review explores multifaceted relationships between cancer, focusing on their modulating TME, activation, members represents promising avenue for advancing precision oncology improving patient By leveraging biomarkers interventions, new strategies be developed optimize diagnosis treatment.

Language: Английский

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Recent advances in oncolytic virus combined immunotherapy in tumor treatment

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101599 - 101599

Published: March 1, 2025

Language: Английский

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Microbiota-centered interventions to boost immune checkpoint blockade therapies

The Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 222(7)

Published: April 22, 2025

Immune checkpoint blockade therapies have markedly advanced cancer treatment by invigorating antitumor immunity and extending patient survival. However, therapeutic resistance immune-related toxicities remain major concerns. Emerging evidence indicates that microbial dysbiosis diminishes response rates, while a diverse gut ecology key beneficial taxa correlate with improved outcomes. Therefore, there is growing understanding manipulating the microbiota could boost therapy efficacy. This review examines burgeoning methods target microbiome to optimize innovative diagnostic tools detect dysbiosis, highlights challenges be addressed in field.

Language: Английский

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