Synergy of Body Composition, Exercise Oncology, and Pharmacokinetics: A Narrative Review of Personalizing Paclitaxel Treatment for Breast Cancer

Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1271 - 1271

Published: April 9, 2025

Background/Objectives: Paclitaxel is a type of small molecule chemotherapy widely used for breast cancer, but its clinical efficacy often hindered by dose-limiting toxicities such as chemotherapy-induced peripheral neuropathy and neutropenia. Traditional dosing based on body surface area does not account variations in composition, which may influence paclitaxel metabolism, toxicity, treatment outcomes. This review explores the interplay between physical activity, pharmacokinetics, emphasizing potential personalized strategies. Methods: A comprehensive narrative was conducted analyzing literature chemotherapy-related toxicities, exercise oncology. Studies examining role skeletal muscle mass, adipose tissue, activity modulating metabolism side effects were included. Results: Evidence suggests that patients with low mass are at higher risk paclitaxel-induced due to altered drug distribution clearance. Sarcopenic obesity, characterized high-fat levels, further exacerbates these risks. Exercise, particularly resistance aerobic training, has been shown improve mitigate enhance tolerance. However, precise mechanisms influences pharmacokinetics remain underexplored. Conclusions: Personalized dosing, considering composition optimize Future research should focus integrating interventions into oncology care refining models interindividual differences metabolism. These advancements could while minimizing cancer patients.

Language: Английский

Response to Letter to the Editor Regarding “Translation, Cross-Cultural Adaptation, and Validation of the Kannada Version of the Exercise Adherence Rating Scale (EARS-Kn) Among Head and Neck Cancer (HNC) Survivors in a Tertiary Care Setup in India” in Integrative Cancer Therapies

Integrative Cancer Therapies, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Language: Английский

Exercise therapy: an effective approach to mitigate the risk of cancer metastasis

World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 16, 2025

Cancer metastasis is a primary contributor to cancer-related mortality, and mitigating the risk of has emerged as central concern in oncology research. In recent years, exercise therapy, non-pharmacological intervention, received considerable attention for its ability enhance patients' quality life prognosis. Exercise significantly inhibits cancer spread, diminishes risk, improves therapy outcomes. Nonetheless, exact mechanisms via which dissemination cells are not fully elucidated. This review seeks examine prospective research avenues treatment metastasis. Moreover, it methodically examines pertinent clinical scientific data, along with efficacy therapies real-world applications. The evaluation moreover suggests future avenues, including more profound exploration mechanisms, augmentation trials, advancement personalized precision enhanced multidisciplinary collaboration. shows significant potential metastasis, incorporation into holistic frameworks advised improve general health prognostic results.

Language: Английский