Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging DOI Open Access
Paweł Kordowitzki

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13318 - 13318

Published: Dec. 12, 2024

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause severe and often fatal illness. The zoonotic EEEV enzootic cycle involves of transmission between Culiseta melanura avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans horses. Interestingly, it has been described that the W132G mutation very low-density lipoprotein receptor (VLDLR), EEEV, significantly enhanced VLDLR-mediated cell attachment EEEV. patient’s metabolism plays pivotal role shaping complex landscape viral zoonosis. represents significant public health concern due its clinical outcomes, challenging epidemiological characteristics, certain risk factors heighten susceptibility specific populations or age groups. Age one several predictors impact outcome infection; juvenile animals appear be particularly vulnerable disease. This also observed natural infections, children are most severely impacted humans. aim this piece shed light on intricate relationship human virus.

Language: Английский

New insights into T cell metabolism in liver cancer: from mechanism to therapy DOI Creative Commons
Jie Xiao, Ting Liu, Fanxin Zeng

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 23, 2025

Abstract Liver cancer is the sixth most common worldwide and third cause of mortality. The development progression liver metastases a multifaceted process involving numerous metabolic pathways. T cells have protective role in defense against cancer, manipulating pathways can alter their antitumor activity. Furthermore, cell nutrition competition lead to dysfunction through various molecular mechanisms. Some nanomaterials drugs improve metabolism promote anti-liver function cells. This review discusses current literature regarding changes targeted therapy for cancer. promise challenges studying target treating are also addressed. Targeting promising approach

Language: Английский

Citations

0
Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging DOI Open Access
Paweł Kordowitzki

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13318 - 13318

Published: Dec. 12, 2024

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause severe and often fatal illness. The zoonotic EEEV enzootic cycle involves of transmission between Culiseta melanura avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans horses. Interestingly, it has been described that the W132G mutation very low-density lipoprotein receptor (VLDLR), EEEV, significantly enhanced VLDLR-mediated cell attachment EEEV. patient’s metabolism plays pivotal role shaping complex landscape viral zoonosis. represents significant public health concern due its clinical outcomes, challenging epidemiological characteristics, certain risk factors heighten susceptibility specific populations or age groups. Age one several predictors impact outcome infection; juvenile animals appear be particularly vulnerable disease. This also observed natural infections, children are most severely impacted humans. aim this piece shed light on intricate relationship human virus.

Language: Английский

Citations

0