Development and validation of a prognostic nomogram for predicting mortality risk in adult rheumatoid arthritis: an analysis of NHANES 1999–2018 data

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

This study aims to identify potential independent risk factors for rheumatoid arthritis (RA)- related mortality and develop a nomogram model predict individualized risk. included 310 RA patients from the National Health Nutrition Examination Survey (NHANES) during 1999 - 2018. We applied LASSO, univariate, multivariate logistic regression analyses determine in training cohort construct model. Calibration plots evaluated nomogram's accuracy. Finally, we established clinical utility through DCA performed internal validation within cohort. Of patients, 140 experienced deaths, corresponding rate of 45.16%. Within cohort, age, heart failure, systemic inflammatory response index (SIRI) emerged as predictors mortality. A model, constructed multivariable analysis, demonstrated an AUC 0. 852 (95% CI: 799 904) 904 846 963) The calibration curve revealed strong agreement between predicted actual probabilities. In both cohorts, highlighted significant net benefits predicting demonstrates SIRI's ability with good discrimination utility. gives clinicians simple tool quickly high promoting early intervention, personalized treatment, better prognosis.

Language: Английский

Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut–Bone Axis

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1513 - 1513

Published: April 29, 2025

Background: Lead (Pb), a pervasive environmental toxicant with specific toxicity to bone, has been recognized as significant etiological factor in the pathogenesis of osteoporosis. While dietary fiber (DF) demonstrates anti-osteoporotic potential, its protective role against Pb-induced bone loss remains unexplored. Methods: This study analyzed association between fiber, blood lead, and osteoporosis based on NHANES database, validated it by constructing lead exposed mouse model. Micro CT was used evaluate microstructure, ELISA detect markers, q-PCR/Western blot measure intestinal tight junction protein, flow cytometry analyze Treg cells colon/bone tissue, GC-MS short chain fatty acids, 16S rRNA sequencing changes gut microbiota. The regulatory mechanism metabolism barrier mice systematically evaluated. Results: Based data analysis, found that can reduce risk populations. Animal experiments have shown intervention significantly increases density, improves microstructure metabolic indicators, repairs damage caused exposure, regulates immune balance mice. At same time, promotes generation acids proliferation beneficial Conclusions: These findings indicate DF mitigates through restoration, SCFA-mediated immunomodulation, microbiota-driven cell expansion along gut–bone axis.

Language: Английский

Preclinical RA: How to halt its progression

Best Practice & Research Clinical Rheumatology, Journal Year: 2024, Volume and Issue: unknown, P. 102030 - 102030

Published: Dec. 1, 2024

Language: Английский