WBC as a mediator between TG/HDL Ratio and gallstone disease across gender differences: NHANES 2017–2020 DOI Creative Commons
Fei Zuo, Qi Jiang, Xiaowei Huang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Gallstone disease (GSD) is associated with insulin resistance (IR) and systemic inflammation, yet the quantitative relationships among these factors remain underexplored. This study investigates association between IR surrogate indices GSD, a focus on mediating role of inflammation potential sex-based differences. Insulin was assessed using biomarkers including triglyceride-to-high-density lipoprotein cholesterol (TG/HDL) ratio, TyG, METS-IR, HOMA-IR, alongside inflammatory markers such as white blood cell (WBC). The TG/HDL GSD through logistic regression models restricted cubic spline analysis. Subgroup analyses were conducted based age, sex, marital status, education, poverty-to-income ratio (PIR) body mass index (BMI). Furthermore, key analysis to investigate WBC in relationship incident GSD. Additionally, interactions sex tested both multiplicative additive scales. Among 3,624 included participants, those diagnosed gallstone disease, female-to-male 2.52:1. highest quartile (Q4) significantly increased risk fully adjusted model (OR = 1.63; 95% CI: 1.07–2.49; P 0.022), whereas HOMA-IR did not show significant associations Q4 (all > 0.05). RCS indicated nonlinear, reverse L-shaped (P 0.049). Mediation revealed that unadjusted model, count mediated accounting for 28.6% total effect. After adjusting partially this relationship, explaining 17.2% Interaction demonstrated interaction < 0.05), without suggesting heightened females. robustly risk, exhibiting nonlinear by indexed count.

Language: Английский

WBC as a mediator between TG/HDL Ratio and gallstone disease across gender differences: NHANES 2017–2020 DOI Creative Commons
Fei Zuo, Qi Jiang, Xiaowei Huang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Gallstone disease (GSD) is associated with insulin resistance (IR) and systemic inflammation, yet the quantitative relationships among these factors remain underexplored. This study investigates association between IR surrogate indices GSD, a focus on mediating role of inflammation potential sex-based differences. Insulin was assessed using biomarkers including triglyceride-to-high-density lipoprotein cholesterol (TG/HDL) ratio, TyG, METS-IR, HOMA-IR, alongside inflammatory markers such as white blood cell (WBC). The TG/HDL GSD through logistic regression models restricted cubic spline analysis. Subgroup analyses were conducted based age, sex, marital status, education, poverty-to-income ratio (PIR) body mass index (BMI). Furthermore, key analysis to investigate WBC in relationship incident GSD. Additionally, interactions sex tested both multiplicative additive scales. Among 3,624 included participants, those diagnosed gallstone disease, female-to-male 2.52:1. highest quartile (Q4) significantly increased risk fully adjusted model (OR = 1.63; 95% CI: 1.07–2.49; P 0.022), whereas HOMA-IR did not show significant associations Q4 (all > 0.05). RCS indicated nonlinear, reverse L-shaped (P 0.049). Mediation revealed that unadjusted model, count mediated accounting for 28.6% total effect. After adjusting partially this relationship, explaining 17.2% Interaction demonstrated interaction < 0.05), without suggesting heightened females. robustly risk, exhibiting nonlinear by indexed count.

Language: Английский

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