Gender differences in the association between weight-adjusted waist index and migraine: A cross-sectional study DOI Creative Commons
Shulong Liu, Jiangting Li, Guobo Xie

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0323087 - e0323087

Published: May 16, 2025

Objective This study examines how weight-adjusted waist index (WWI) correlates with the occurrence of migraine in U.S. adults. Background Being overweight significantly increases likelihood experiencing migraines; nonetheless, conventional metrics like circumference (WC) and body mass (BMI) might not completely capture level risk tied to obesity. WWI integrates strengths WC while minimizing its correlation BMI, which make it a more accurate indicator central obesity-related susceptibility. Methods performed cross-sectional analysis using data from 9,688 participants obtained National Health Nutrition Examination Survey (NHANES), covering years 1999–2004. Migraine was evaluated through questionnaires, participants’ computed. Weighted multivariable logistic regression models were used examine association between migraines. Restricted cubic splines (RCS) applied evaluate dose-response relationship Furthermore, interaction tests subgroup analyses executed. The receiver operating characteristic (ROC) curve, paired DeLong et al.’s test, employed compare predictive power WWI, for Results overall prevalence migraines found be 21.50% (weighted population: 31,888,075 out 148,278,824). In Model 3, link women showed no statistical significance (OR = 0.94, 95% CI: 0.82–1.07). this model, each unit increase among men linked 22% higher 1.22, 1.05–1.42). When stratified by quintiles, individuals third quintile (Q3) displayed 69% compared those first (Q1) 1.69, 1.19–2.40), significant inflection point observed at 10.95 cm/√kg. Significant interactions noted various age groups (p 0.018). demonstrated stronger capability BMI WC. Conclusion A U-shaped positive observerd adult males U.S., females. Within context WC, exhibited superior capacity

Language: Английский

Gene Expression Changes as Biomarkers of Immunosenescence in Bulgarian Individuals of Active Age DOI Creative Commons
Dragomira Nikolova, Yana Todorova,

Zora Hammoudeh

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 721 - 721

Published: March 15, 2025

Background/Objectives: Immunosenescence implies innate and adaptive immunity dysfunction, which naturally occurs with aging. It is a complex multifactorial process can be triggered by either genetic changes, immune changes or both. Numerous research studies have shown that the of senescence goes alongside chronic activation. The purpose this study to analyze in expression genes associated responses order identify reliable biomarkers for Methods: For aim, 55 clinically healthy individuals active age (21–65 years) were distributed based on immunophenotyping two groups, without signs premature senescence. A gene analysis was subsequently made those differentially expressed presented interpreted. Results: Altogether, forty-eight (48) exhibited differential between most showed up-regulation (45) (fold change more than 2), only three down-regulated less −2). highest positive fold IL-1β (10.76), BCL6 (13.25) CCL4 (15.91), while negative documented IL23R (−3.10), IL5 (−2.66) PTGS2 (COX-2) (−2.15). Conclusions: Our results reveal immunosenescence positively inflammation, typical aging process. On other hand, we identified markers possible protective effects against oxidative stress tumorigenesis. These findings aid early diagnosis degenerative diseases subclinical phase, as well development strategies prevent processes

Language: Английский

Citations

0
Gender differences in the association between weight-adjusted waist index and migraine: A cross-sectional study DOI Creative Commons
Shulong Liu, Jiangting Li, Guobo Xie

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0323087 - e0323087

Published: May 16, 2025

Objective This study examines how weight-adjusted waist index (WWI) correlates with the occurrence of migraine in U.S. adults. Background Being overweight significantly increases likelihood experiencing migraines; nonetheless, conventional metrics like circumference (WC) and body mass (BMI) might not completely capture level risk tied to obesity. WWI integrates strengths WC while minimizing its correlation BMI, which make it a more accurate indicator central obesity-related susceptibility. Methods performed cross-sectional analysis using data from 9,688 participants obtained National Health Nutrition Examination Survey (NHANES), covering years 1999–2004. Migraine was evaluated through questionnaires, participants’ computed. Weighted multivariable logistic regression models were used examine association between migraines. Restricted cubic splines (RCS) applied evaluate dose-response relationship Furthermore, interaction tests subgroup analyses executed. The receiver operating characteristic (ROC) curve, paired DeLong et al.’s test, employed compare predictive power WWI, for Results overall prevalence migraines found be 21.50% (weighted population: 31,888,075 out 148,278,824). In Model 3, link women showed no statistical significance (OR = 0.94, 95% CI: 0.82–1.07). this model, each unit increase among men linked 22% higher 1.22, 1.05–1.42). When stratified by quintiles, individuals third quintile (Q3) displayed 69% compared those first (Q1) 1.69, 1.19–2.40), significant inflection point observed at 10.95 cm/√kg. Significant interactions noted various age groups (p 0.018). demonstrated stronger capability BMI WC. Conclusion A U-shaped positive observerd adult males U.S., females. Within context WC, exhibited superior capacity

Language: Английский

Citations

0