Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development DOI Creative Commons
Hisaka Kurita,

Kazuki Ohuchi,

Masatoshi Inden

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 167 - 167

Published: Feb. 27, 2025

We are exposed to a variety of environmental chemicals in our daily lives. It is possible that the effects this chemical exposure could accumulate organism some form and influence health disease development. The extend throughout human lifetime, not only after birth, but also during embryonic period. Epigenetics an important target for molecular mechanisms effects. mechanism gene transcription regulation does involve changes DNA sequence. Developmental Origins Health Disease (DOHaD) theory has been proposed, which such as period mediated by epigenetic changes, may lead risk development adverse maturity. This review summarizes association between epigenetics well-known non-essential toxic heavy metals (methylmercury, cadmium, arsenic, lead), representative group chemicals. In future, it will be predict unknown combined exposures. addition, further experimental investigations using animals accumulation knowledge needed study transgenerational future.

Language: Английский

Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development DOI Creative Commons
Hisaka Kurita,

Kazuki Ohuchi,

Masatoshi Inden

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 167 - 167

Published: Feb. 27, 2025

We are exposed to a variety of environmental chemicals in our daily lives. It is possible that the effects this chemical exposure could accumulate organism some form and influence health disease development. The extend throughout human lifetime, not only after birth, but also during embryonic period. Epigenetics an important target for molecular mechanisms effects. mechanism gene transcription regulation does involve changes DNA sequence. Developmental Origins Health Disease (DOHaD) theory has been proposed, which such as period mediated by epigenetic changes, may lead risk development adverse maturity. This review summarizes association between epigenetics well-known non-essential toxic heavy metals (methylmercury, cadmium, arsenic, lead), representative group chemicals. In future, it will be predict unknown combined exposures. addition, further experimental investigations using animals accumulation knowledge needed study transgenerational future.

Language: Английский

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