Frontiers in Hematology, Journal Year: 2025, Volume and Issue: 4
Published: April 14, 2025
Maternal obesity, often linked to the consumption of a high-fat Western-style diet (WSD), poses significant risks both maternal and fetal health. This review explores impact obesity on hematopoietic stem progenitor cells (HSPCs), highlighting how metabolic inflammatory shifts in environment affect HSPC proliferation, differentiation, long-term immune system development. leads hormonal imbalances, increased cytokines, placental insufficiency, altered nutrient availability that disrupt normal function, potentially predisposing offspring dysfunction, disorders, cardiovascular diseases later life. Notably, skews differentiation toward myeloid lineage, which can impair adaptive responses increase risk autoimmune infections. Furthermore, diet-driven epigenetic transcriptional reprogramming HSPCs exacerbates chronic inflammation, reinforcing pro-inflammatory phenotype downstream progeny persists into postnatal stages. The also emphasizes need for further research clarify mechanisms underlying these effects across different species developmental stages, as well potential targeted interventions mitigate adverse impacts hematopoiesis lifelong health outcomes.
Language: Английский