Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy DOI Creative Commons
Abdullah F. U. H. Saeed

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 741 - 741

Published: May 19, 2025

Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research

Language: Английский

Commentary on “Histopathological invasion patterns and prognosis in oral squamous cell carcinoma: A retrospective analysis of 560 Cases” DOI

Jospin Sindya,

Jeevitha Rajanathadurai,

Elumalai Perumal

et al.

Oral Oncology, Journal Year: 2025, Volume and Issue: 164, P. 107297 - 107297

Published: April 11, 2025

Language: Английский

Citations

0
Interactions between cancer cells and tumor-associated macrophages in tumor microenvironment DOI
Lu Liu, Yafei Li, Bo Li

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189344 - 189344

Published: May 1, 2025

Language: Английский

Citations

0
Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy DOI Creative Commons
Abdullah F. U. H. Saeed

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 741 - 741

Published: May 19, 2025

Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research

Language: Английский

Citations

0