Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho DOI Open Access
Asma S. Alonazi,

Rana M. Aloraini,

Lama M. Albulayhi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3990 - 3990

Published: April 23, 2025

Cellular senescence is a hallmark of aging and contributes to age-related diseases, including diabetic nephropathy (DN). Additionally, macrophage-mediated inflammation has been linked with DKD. Therefore, we investigated the effect macrophage depletion on kidney cell in DN, focusing relationship between GDF-15 Klotho signaling pathways. Wistar albino rats (n = 24) were divided into four groups: healthy control, liposomal clodronate (LC)-treated healthy, diabetic, LC-treated groups. Rats groups intravenously administered LC once week for 4 weeks. Rat models type 2 diabetes successfully established via administration streptozotocin high-fat diet, as evidenced by increased blood glucose levels, weight body (KW/BW) ratio, serum albumin, creatinine, urea damage, oxidative stress. However, LC-mediated reduced KW/BW improved parameters, decreased inflammatory markers (IL-6 TNF-α), ameliorated treatment promoted polarization towards anti-inflammatory phenotype, downregulated expression, upregulated damage. In conclusion, combats modulating GDF-15, indicating their potential novel targets DN treatment.

Language: Английский

Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease DOI Open Access

Dexiang Xia,

Qinwen Zheng,

Yue Liu

et al.

Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally. Recent groundbreaking preclinical clinical research underscores the pivotal role metabolite remodelling in pathology CVD. This metabolic transformation not only directly fuels progression CVD but also profoundly influences immune response within cardiovascular system. In this review, we focused on complex interactions between alterations responses during course Furthermore, explore potential therapeutic interventions that could be developed based understanding dysregulation By targeting these immunological pathways, novel strategies for prevention treatment CVDs might to improve patient outcomes reduce global burden disease.

Language: Английский

Citations

0
Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho DOI Open Access
Asma S. Alonazi,

Rana M. Aloraini,

Lama M. Albulayhi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3990 - 3990

Published: April 23, 2025

Cellular senescence is a hallmark of aging and contributes to age-related diseases, including diabetic nephropathy (DN). Additionally, macrophage-mediated inflammation has been linked with DKD. Therefore, we investigated the effect macrophage depletion on kidney cell in DN, focusing relationship between GDF-15 Klotho signaling pathways. Wistar albino rats (n = 24) were divided into four groups: healthy control, liposomal clodronate (LC)-treated healthy, diabetic, LC-treated groups. Rats groups intravenously administered LC once week for 4 weeks. Rat models type 2 diabetes successfully established via administration streptozotocin high-fat diet, as evidenced by increased blood glucose levels, weight body (KW/BW) ratio, serum albumin, creatinine, urea damage, oxidative stress. However, LC-mediated reduced KW/BW improved parameters, decreased inflammatory markers (IL-6 TNF-α), ameliorated treatment promoted polarization towards anti-inflammatory phenotype, downregulated expression, upregulated damage. In conclusion, combats modulating GDF-15, indicating their potential novel targets DN treatment.

Language: Английский

Citations

0