Comprehensive Overview of Cytokine Interplay in Vitiligo: A Decade of Meta-Analyses Systematically Reviewed DOI Creative Commons
Alessia Paganelli, Cristina Cristofoletti, Francesco Moro

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 684 - 684

Published: April 23, 2025

(1) Background: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction. Despite metabolic disturbances and oxidative stress also playing a key role in its pathogenesis, accumulating evidence highlights prominent for cytokine dysregulation. (2) Methods: A systematic search was conducted to identify meta-analyses published the last decade that investigated involvement vitiligo. (3) Results: Based on predefined inclusion criteria, nine were retrieved reviewed. The findings confirm central interferon-gamma (IFN-γ) vitiligo although recent suggest IFN-γ gene polymorphisms are more broadly associated with autoimmunity rather than being vitiligo-specific. Elevated interleukin-17 (IL-17) levels have been consistently reported patients, supporting contribution immune-mediated Regulatory T cell dysfunction appears play crucial disease progression. Additionally, TNF-α-308 G/A polymorphism has linked genetic susceptibility vitiligo, particularly specific populations, reinforcing of TNF-α immune Lastly, chemokines involved recruitment melanocytes further illustrate complex inflammatory network underlying disease. (4) Conclusions: This review consolidates from meta-analyses, underscoring significance dysregulation highlighting potential therapeutic targets.

Language: Английский

Comprehensive Overview of Cytokine Interplay in Vitiligo: A Decade of Meta-Analyses Systematically Reviewed DOI Creative Commons
Alessia Paganelli, Cristina Cristofoletti, Francesco Moro

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 684 - 684

Published: April 23, 2025

(1) Background: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction. Despite metabolic disturbances and oxidative stress also playing a key role in its pathogenesis, accumulating evidence highlights prominent for cytokine dysregulation. (2) Methods: A systematic search was conducted to identify meta-analyses published the last decade that investigated involvement vitiligo. (3) Results: Based on predefined inclusion criteria, nine were retrieved reviewed. The findings confirm central interferon-gamma (IFN-γ) vitiligo although recent suggest IFN-γ gene polymorphisms are more broadly associated with autoimmunity rather than being vitiligo-specific. Elevated interleukin-17 (IL-17) levels have been consistently reported patients, supporting contribution immune-mediated Regulatory T cell dysfunction appears play crucial disease progression. Additionally, TNF-α-308 G/A polymorphism has linked genetic susceptibility vitiligo, particularly specific populations, reinforcing of TNF-α immune Lastly, chemokines involved recruitment melanocytes further illustrate complex inflammatory network underlying disease. (4) Conclusions: This review consolidates from meta-analyses, underscoring significance dysregulation highlighting potential therapeutic targets.

Language: Английский

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